A5008459293- Heart Failure Treatment and Management
- Nutrition and Health in Aging
- Frailty in Older Adults
- Cardiovascular Function and Risk Factors
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Body Composition Measurement Techniques
- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Cardiovascular and exercise physiology
- Kruppel-like factors research
- Dialysis and Renal Disease Management
- Health Systems, Economic Evaluations, Quality of Life
- Electrolyte and hormonal disorders
- Pharmaceutical Practices and Patient Outcomes
- Digestive system and related health
- Liver Disease and Transplantation
- Protease and Inhibitor Mechanisms
- Cardiac Imaging and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Liver Disease Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
Juntendo University
2021-2025
Kanazawa University
2023-2025
Osaka University of Pharmaceutical Sciences
2021-2023
Osaka Medical and Pharmaceutical University
2017-2021
Juntendo University Hospital
2021
The University of Tokyo
2011-2016
Abstract Background The purpose of this study was to clarify the prevalence, association with frailty and exercise capacity, prognostic implication sarcopenic obesity in patients heart failure. Methods present included 779 older adults hospitalized failure (median age: 81 years; 57.4% men). Sarcopenia diagnosed based on guidelines by Asian Working Group for Sarcopenia. Obesity defined as percentage body fat mass (FM) obtained bioelectrical impedance analysis. FM cut-off points were 38% women...
Cachexia substantially impacts the prognosis of patients with heart failure (HF); however, there is no standard method for cachexia diagnosis. This study aimed to investigate association Evans's criteria, consisting multiple assessments, HF in older adults.This a secondary analysis data from FRAGILE-HF study, prospective multicentre cohort that enrolled consecutive hospitalized aged ≥65 years HF. Patients were divided into two groups: and non-cachexia groups. was defined according criteria...
Although frailty is strongly associated with mortality in patients heart failure (HF), the risk of which specific cause death being complicated unclear. We aimed to clarify association between multidomain and causes elderly hospitalized HF.
Abstract Aims Recently, liver fibrosis markers, such as the fibrosis‐4 index (FIB‐4), have been shown to be associated with prognosis in patients heart failure. The fibrosis‐5 (FIB‐5) index, which assesses albumin, alkaline phosphatase, aspartate transaminase, alanine aminotransferase and platelet count, is a simple marker that was reported superior FIB‐4 for differentiation of fibrosis. This study aimed compare prognostic value FIB‐5 Methods results scores were calculated at discharge 906...
Owing to the paucity of data, this study aimed investigate sex differences in clinical features and prognosis patients with cardiac sarcoidosis (CS).This was a secondary analysis ILLUstration Management prognosIs JapaNese PATiEnts Cardiac Sarcoidosis registry-a retrospective multicentre registry that enrolled CS between 2001 2017. The primary outcome potentially fatal ventricular arrhythmia events (pFVAEs)-a composite sudden death, sustained tachycardia lasting >30 s, fibrillation or...
Current guidelines recommend placing an implantable cardiac defibrillator for patients with sarcoidosis and a severely impaired left ventricular ejection fraction (LVEF) of ≤35%. In this study, we determined the association between mild or moderate LVEF impairment fatal arrhythmic event (FVAE).
Abstract Aims The benefits of exercise in patients with heart failure are well documented. However, to date, the association between habits and prognosis is yet be evaluated. In this study, we investigated pre-hospital post-discharge older adult failure. Methods This post-hoc analysis utilised data from FRAGILE-HF which included 1,262 aged ≥ 65 years who required hospitalisation for decompensation. Exercise before were assessed through a three-question physical activity assessment tool....
<title>Abstract</title> The majority of gastric cancer cells proliferate in a Wnt ligand-dependent manner. In this study, we examined the role signaling development and metastasis cancer. We generated mice with mutations <italic>Kras</italic>, <italic>Tgfbr2</italic>, <italic>Trp53</italic> (KTP mice) as well same plus <italic>Wnt1</italic> expression (WKTP mucosa. KTP displayed metaplasia parietal cell loss, whereas WKTP developed dysplastic tumors, highlighting initial stage primary...
Abstract Frailty is a common comorbidity associated with adverse events in patients heart failure, and early recognition key to improving its management. We hypothesized that the AST ALT ratio (AAR) could be marker of frailty failure. Data from FRAGILE-HF study were analyzed. A total 1327 aged ≥ 65 years hospitalized failure categorized into three groups based on their AAR at discharge: low (AAR < 1.16, n = 434); middle (1.16 ≤ 1.70, 487); high 406). The primary endpoint was one-year...
Abstract Aims Frailty is highly prevalent and associated with poor prognoses in elderly patients heart failure (HF). However, the potential effects of physical frailty on benefits HF medications are unclear. We aimed to determine influence prognosis reduced mildly ejection fraction (HFr/mrEF). Methods results From combined database FRAGILE‐HF Kitasato cohorts, hospitalized a left ventricular < 50% age ≥ 65 years were analysed. Patients treated or without renin‐angiotensin‐aldosterone...
Abstract Background Although many human papillomavirus (HPV)–targeted therapeutic vaccines have been examined for efficacy in clinical trials, none translated into use. These previous agents were mostly administered by intramuscular or subcutaneous injection to induce systemic immunity. We investigated the safety and of an HPV-16 E7-expressing lacticaseibacillus-based oral vaccine. Methods In a double-blind, placebo-controlled, randomized trial, total 165 patients with HPV-16–positive...
This study aimed to investigate the prevalence, clinical characteristics, and prognostic value of bendopnea in older patients hospitalized for heart failure.
Social factors encompass a broad spectrum of nonmedical factors, including objective (social isolation [SI]) and perceived (loneliness) conditions. Although social have attracted considerable research attention, information regarding their impact on patients with heart failure is scarce. We aimed to investigate the prognostic SI loneliness in older failure.
ABSTRACT Background The Asian Working Group for Cachexia (AWGC) proposed a new definition of cachexia; however, its impact on cachexia prevalence and overlaps with other conditions, such as sarcopenia malnutrition, are unclear. We investigated these aspects the prognostic value based AWGC mortality in older patients heart failure (HF). Methods This study was secondary analysis prospective multicentre cohort, namely, FRAGILE‐HF cohort study. Older (≥ 65 years) who had been hospitalized due to...
SIRT6, a member of the sirtuin family, has been identified as candidate tumor suppressor. To pursue role SIRT6 in endometrial cancer, we investigated anti‐tumorigenic function SIRT6. The expression negatively affected proliferation AN3CA and KLE cancer cells. Increased resulted induction apoptosis by repressing anti‐apoptotic protein survivin. Consistent with this result, survivin inhibitor YM155 efficiently inhibited cellular induced apoptosis. These results revealed that might suppressor
This study aimed to compare bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DEXA) in measuring skeletal muscle mass (MM), its prognostic implications old patients with heart failure.We prospectively evaluated MM measured by both BIA DEXA 226 hospitalized elderly (≥65 years) failure. The cut-off values proposed the Asian Working Group Sarcopenia were used define low MM. endpoint was all-cause death.The median age of cohort 82 years (interquartile range: 75-87),...