A5022772124- Nutrition and Health in Aging
- Cardiovascular and exercise physiology
- Frailty in Older Adults
- Heart Failure Treatment and Management
- Cardiac Imaging and Diagnostics
- Cardiac Health and Mental Health
- Cardiovascular Function and Risk Factors
- Microbial bioremediation and biosurfactants
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Microbial Metabolic Engineering and Bioproduction
- Health Systems, Economic Evaluations, Quality of Life
- Intensive Care Unit Cognitive Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Stroke Rehabilitation and Recovery
- Body Composition Measurement Techniques
- Balance, Gait, and Falls Prevention
- Muscle activation and electromyography studies
- 3D Printing in Biomedical Research
- Tracheal and airway disorders
- Hip and Femur Fractures
- Biofuel production and bioconversion
- Cancer Cells and Metastasis
- Dialysis and Renal Disease Management
- Pancreatic and Hepatic Oncology Research
Daiichi-Sankyo (Japan)
2025
Shinshu University Hospital
2015-2024
Toyobo (Japan)
2013-2024
National College of Technology, Wakayama College
2024
Kyoto University
2008-2024
Shizuoka Cancer Center
2021-2024
Santen (Japan)
2024
Kyoto Min-iren Asukai Hospital
2024
Scientific Research WorkS Peer Support Group
2024
Fukuyama University
2024
To date, a large number of sequences protein kinases that belong to the sucrose nonfermenting1-related kinase2 (SnRK2) family are found in databases. However, only limited numbers members have been characterized and implicated abscisic acid (ABA) hyperosmotic stress signaling. We identified 10 SnRK2 encoded by rice (Oryza sativa) genome. Each was expressed cultured cell protoplasts, its regulation analyzed. Here, we demonstrate all activated three them also ABA. Surprisingly, there were no...
The plant hormone abscisic acid (ABA) induces gene expression via the ABA-response element (ABRE) present in promoters of ABA-regulated genes. A group bZIP proteins have been identified as ABRE-binding factors (ABFs) that activate transcription through this cis element. rice ABF, TRAB1, has shown to be activated ABA-dependent phosphorylation. While a large number signalling are involved stomatal regulation by ABA, relatively less is known about ABA-signalling pathway leads expression. We...
Abstract Aims Sarcopenia, one of the extracardiac factors for reduced functional capacity and poor outcome in heart failure (HF), may act differently between HF with preserved ejection fraction (HFpEF) (HFrEF). We sought to investigate impact sarcopenia on mortality HFpEF HFrEF. Methods results performed a post hoc analysis multicentre prospective cohort study, including 942 consecutive older (age ≥65 years) hospitalized patients: 475 (ejection ≥45%, age 81 ± 7 years, 48.8% men) 467 HFrEF...
Abstract Background The purpose of this study was to clarify the prevalence, association with frailty and exercise capacity, prognostic implication sarcopenic obesity in patients heart failure. Methods present included 779 older adults hospitalized failure (median age: 81 years; 57.4% men). Sarcopenia diagnosed based on guidelines by Asian Working Group for Sarcopenia. Obesity defined as percentage body fat mass (FM) obtained bioelectrical impedance analysis. FM cut-off points were 38% women...
Skeletal muscle wasting is common and insidious in patients who are undergoing hemodialysis. However, the association between lower extremity strength all-cause mortality remains unclear this population.The purpose of study was to investigate prognostic significance on 7-year survival a cohort were clinically stable hemodialysis.A prospective conducted.A total 190 Japanese outpatients maintenance hemodialysis 3 times per week at center followed for up 7 years. Lower evaluated using handheld...
Circulating tumor cells (CTCs) in the blood of patients with epithelial malignancies provide a promising and minimally invasive source for early detection metastasis, monitoring therapeutic effects basic research addressing mechanism metastasis. In this study, we developed new filtration-based, sensitive CTC isolation device. This device consists 3-dimensional (3D) palladium (Pd) filter an 8 µm-sized pore lower layer 30 pocket upper to trap CTCs on micro-fabricated by precise lithography...
Background Frailty is conceptualized as an accumulation of deficits in multiple areas and strongly associated with the prognosis heart failure (HF). However, social domain frailty less well investigated. We prospectively evaluated clinical characteristics prognostic impact (SF) elderly patients HF. Methods Results FRAGILE-HF (prevalence value physical geriatric hospitalized for failure) a multicenter, prospective cohort study focusing on HF aged ≥65 years. defined SF by Makizako's 5 items,...
Although evidence suggests that cognitive decline and physical frailty in elderly patients with heart failure (HF) are associated prognosis, the impact of concurrent impairment, is, frailty, on prognosis has yet to be fully investigated. The current study sought investigate prevalence prognostic HF.This is a sub-analysis FRAGILE-HF, prospective multicentre observational involving aged ≥65 years hospitalized for HF. Fried criteria Mini-Cog were used diagnose respectively. association between...
Although frailty is strongly associated with mortality in patients heart failure (HF), the risk of which specific cause death being complicated unclear. We aimed to clarify association between multidomain and causes elderly hospitalized HF.
Mannosylerythritol lipids (MELs), are produced from feedstock by the genus Pseudozyma, and most promising biosurfactants known due to its versatile interfacial biochemical actions. In order broaden application in cosmetics, hair care properties of MELs were investigated using damaged hair. On electron microscopic observation, was dramatically recovered with applying MEL-A MEL-B. The tensile strength increased treatment (122.0 +/- 13.5 gf/p), MEL-B (119.4 7.6 gf/p) ceramide (100.7 15.9...
Glycolipid biosurfactants, such as mannosylerythritol lipids (MELs), are produced by different yeasts belonging to the genus Pseudozyma and have been attracting much attention new cosmetic ingredients owing their unique liquid-crystal-forming moisturizing properties. In this study, effects of MEL derivatives on skin were evaluated in detail using a three-dimensional cultured human model an vivo study. The cells treated with sodium dodecyl sulfate (SDS), SDS-damaged basis cell viability. Most...
Patient satisfaction is important in pain management. Satisfaction with prescribed relievers and continued use of these drugs may be affected by a patient's understanding their efficacy safety. We investigated the association between patients' medication for three oral (lasmiditan, mirogabalin, tramadol) that recently became available Japan. This questionnaire-based, cross-sectional study included adult patients taking after April 2023. The primary endpoint was overall (five-point rating)...
Mannosylerythritol lipids (MELs) are produced in large amounts from renewable vegetable oils by Pseudozyma antarctica, and the most promising biosurfactants known due to its versatile interfacial biochemical actions. In order broaden application cosmetics pharmaceuticals, skin care property of MEL-A, major component MELs, was investigated using a three-dimensional cultured human model. The cells were treated with sodium dodecyl sulfate (SDS) solution 1 wt%, effects different on SDS-damaged...
A basidiomycetous yeast, Pseudozyma graminicola CBS 10092, was found to accumulate a large amount of glycolipids in the cultured medium when grown on soybean oil as sole carbon source. Based thin layer chromatography, extracellular gave spots corresponding those mannosylerythritol lipids (MELs), which are highly functional and promising biosurfactants. From structural characterization by 1H 13C NMR, main product identified 4-O-[(4′-mono-O-acetyl-2′,...
Cachexia substantially impacts the prognosis of patients with heart failure (HF); however, there is no standard method for cachexia diagnosis. This study aimed to investigate association Evans's criteria, consisting multiple assessments, HF in older adults.This a secondary analysis data from FRAGILE-HF study, prospective multicentre cohort that enrolled consecutive hospitalized aged ≥65 years HF. Patients were divided into two groups: and non-cachexia groups. was defined according criteria...