A5016293764- Nutrition and Health in Aging
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Stroke Rehabilitation and Recovery
- Body Composition Measurement Techniques
- Lung Cancer Treatments and Mutations
- Dialysis and Renal Disease Management
- Cardiovascular and exercise physiology
- Cardiac Health and Mental Health
- Cardiac Valve Diseases and Treatments
- Balance, Gait, and Falls Prevention
- Erythropoietin and Anemia Treatment
- Inflammatory Biomarkers in Disease Prognosis
- GDF15 and Related Biomarkers
- Diverse Approaches in Healthcare and Education Studies
- Reproductive Physiology in Livestock
- Cerebrovascular and Carotid Artery Diseases
- Hip and Femur Fractures
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Risk Factors
- Muscle and Compartmental Disorders
- Connective tissue disorders research
- Blood Pressure and Hypertension Studies
Odawara Municipal Hospital
2016-2024
Kitasato University
2008-2021
Sakakibara Hospital
2014-2015
Kitasato Institute Hospital
2008
Obihiro University of Agriculture and Veterinary Medicine
2000
Kochi Medical School Hospital
1996
Abstract Aims Sarcopenia, one of the extracardiac factors for reduced functional capacity and poor outcome in heart failure (HF), may act differently between HF with preserved ejection fraction (HFpEF) (HFrEF). We sought to investigate impact sarcopenia on mortality HFpEF HFrEF. Methods results performed a post hoc analysis multicentre prospective cohort study, including 942 consecutive older (age ≥65 years) hospitalized patients: 475 (ejection ≥45%, age 81 ± 7 years, 48.8% men) 467 HFrEF...
Abstract Background The purpose of this study was to clarify the prevalence, association with frailty and exercise capacity, prognostic implication sarcopenic obesity in patients heart failure. Methods present included 779 older adults hospitalized failure (median age: 81 years; 57.4% men). Sarcopenia diagnosed based on guidelines by Asian Working Group for Sarcopenia. Obesity defined as percentage body fat mass (FM) obtained bioelectrical impedance analysis. FM cut-off points were 38% women...
Background Frailty is conceptualized as an accumulation of deficits in multiple areas and strongly associated with the prognosis heart failure (HF). However, social domain frailty less well investigated. We prospectively evaluated clinical characteristics prognostic impact (SF) elderly patients HF. Methods Results FRAGILE-HF (prevalence value physical geriatric hospitalized for failure) a multicenter, prospective cohort study focusing on HF aged ≥65 years. defined SF by Makizako's 5 items,...
Although evidence suggests that cognitive decline and physical frailty in elderly patients with heart failure (HF) are associated prognosis, the impact of concurrent impairment, is, frailty, on prognosis has yet to be fully investigated. The current study sought investigate prevalence prognostic HF.This is a sub-analysis FRAGILE-HF, prospective multicentre observational involving aged ≥65 years hospitalized for HF. Fried criteria Mini-Cog were used diagnose respectively. association between...
Cachexia substantially impacts the prognosis of patients with heart failure (HF); however, there is no standard method for cachexia diagnosis. This study aimed to investigate association Evans's criteria, consisting multiple assessments, HF in older adults.This a secondary analysis data from FRAGILE-HF study, prospective multicentre cohort that enrolled consecutive hospitalized aged ≥65 years HF. Patients were divided into two groups: and non-cachexia groups. was defined according criteria...
Although frailty is strongly associated with mortality in patients heart failure (HF), the risk of which specific cause death being complicated unclear. We aimed to clarify association between multidomain and causes elderly hospitalized HF.
We previously proposed that an endothelin-angiotensin-atrial natriuretic peptide system may contribute to inducing ovulation of mature bovine follicles by modulating follicular secretion steroids and prostaglandins (PGs). Thus, this study aimed determine the real-time changes in local release angiotensin II (Ang II), endothelin (ET), atrial (ANP), PGF2α, steroid hormones from during periovulatory period vivo. Seven cows were treated for superovulation using FSH PGF2α injections. Two dialysis...
Abstract Frailty is a common comorbidity associated with adverse events in patients heart failure, and early recognition key to improving its management. We hypothesized that the AST ALT ratio (AAR) could be marker of frailty failure. Data from FRAGILE-HF study were analyzed. A total 1327 aged ≥ 65 years hospitalized failure categorized into three groups based on their AAR at discharge: low (AAR < 1.16, n = 434); middle (1.16 ≤ 1.70, 487); high 406). The primary endpoint was one-year...
ABSTRACT Background The Asian Working Group for Cachexia (AWGC) proposed a new definition of cachexia; however, its impact on cachexia prevalence and overlaps with other conditions, such as sarcopenia malnutrition, are unclear. We investigated these aspects the prognostic value based AWGC mortality in older patients heart failure (HF). Methods This study was secondary analysis prospective multicentre cohort, namely, FRAGILE‐HF cohort study. Older (≥ 65 years) who had been hospitalized due to...
There have been no investigations of the prevalence and clinical implications coexistence anaemia frailty in older patients hospitalized with heart failure (HF) despite their association adverse health outcomes. The present study was performed to determine prognostic value HF. We post hoc analysis consecutive HF ≥65 years old enrolled FRAGILE-HF, which prospective, multicentre, observational study. Anaemia defined as haemoglobin < 13 g/dL men <12 women, evaluated according Fried phenotype...
Abstract Aims Although aging is strongly associated with both heart failure and a decline in gait speed, definition of slowness incorporating an age‐related has yet to be developed. We aimed define event‐driven cut‐off for the relative speed against age‐adjusted reference values derived from general population evaluate its prognostic implications. Methods results Standardized (SGS) was defined as median stratified by age, sex, height 3777 elderly (age ≥ 65 years) individuals without history...
In heart failure (HF), inflammation is linked to malnutrition and impaired physical function. this study, we aimed assess how novel nutritional-inflammatory markers lymphocyte-to-C-reactive protein ratio (LCR) score (LCS) are associated with the nutritional status, function, prognosis of patients HF.
Abstract Aims A patient's understanding of his or her own comorbidities is part the recommended patient education for those with heart failure. The accuracy patients' their and its prognostic impact have not been reported. Methods results Patients hospitalized failure ( n = 1234) aged ≥65 years (mean age: 80.1 ± 7.7 years; 531 females) completed a questionnaire regarding diagnoses diabetes, malignancy, stroke, hypertension, chronic obstructive pulmonary disease (COPD), coronary artery (CAD)....
Abstract Aims MitraScore is a novel, simple, and manually calculatable risk score developed as prognostic model for patients undergoing transcatheter edge‐to‐edge repair (TEER) mitral regurgitation. As its components are considered in heart failure (HF), we aimed to investigate the usefulness of HF patients. Methods results We calculated 1100 elderly (>65 years old) hospitalized prospective multicentre FRAGILE‐HF study compared ability with other simple scores. The primary endpoint was...
<b><i>Objective:</i></b> The aim of this study was to confirm the effects chronic kidney disease (CKD) and anemia on physical function clarify whether interaction between CKD has an additive effect. <b><i>Design:</i></b> Eligible subjects were heart failure (HF) patients who discharged March 2007 August 2009. A total 102 HF (33% females; mean age: 68 ± 14 years) enrolled in present study. defined as estimated glomerular filtration rate <60...
Abstract Although postural hypotension (PH) is reportedly associated with mortality in the general population, prognostic value for heart failure unclear. This was a post-hoc analysis of FRAGILE-HF, prospective multicenter observational study focusing on frailty elderly patients failure. Overall, 730 aged ≥ 65 years who were hospitalized enrolled. PH defined by evaluating seated PH, and as fall 20 mmHg systolic and/or 10 diastolic blood pressure within 3 min after transition from supine to...