A5075577875- Peripheral Artery Disease Management
- Angiogenesis and VEGF in Cancer
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Vascular Procedures and Complications
- Coronary Interventions and Diagnostics
- Cardiac Structural Anomalies and Repair
- Systemic Sclerosis and Related Diseases
- Mesenchymal stem cell research
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Renal and Vascular Pathologies
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- COVID-19 and healthcare impacts
- Aortic aneurysm repair treatments
- Diagnosis and Treatment of Venous Diseases
- Abdominal vascular conditions and treatments
- Lipoproteins and Cardiovascular Health
- Pulmonary Hypertension Research and Treatments
- Lymphatic System and Diseases
- Aortic Thrombus and Embolism
- Acute Ischemic Stroke Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Vasculitis and related conditions
Kyoto Prefectural University of Medicine
2016-2025
Previous studies have reported the efficacy and safety of therapeutic angiogenesis through bone marrow-derived mononuclear cell (BM-MNC) implantation in patients with no-option chronic limb-threatening ischemia (CLTI) from atherosclerotic lower extremity artery disease (LEAD). However, uncertain clinical prognostic factors impact treatment outcomes. This study aimed to elucidate long-term outcomes LEAD-derived CLTI after BM-MNC identify factors.In this retrospective, single-center,...
Background: Basic fibroblast growth factor (bFGF) is an angiogenic with a short half-life. Because recombinant bFGF in clinical use, we hypothesized that the localization of atelocollagen would have effects at injection site normal and hind limb ischemic animal models.
Background:The Therapeutic Angiogenesis by Cell Transplantation (TACT) trial demonstrated the efficacy and safety of autologous bone marrow-derived mononuclear cells (BM-MNCs) in patients with critical limb ischemia (CLI). The present study aimed to assess long-term clinical outcomes therapeutic angiogenesis using BM-MNC implantation under advanced medical treatment Japan.
Thromboangiitis obliterans (TAO) can lead to the development of critical limb-threatening ischemia (CLTI). Despite conventional treatments, such as smoking cessation or revascularization, young patients (<50 years) still require limb amputation. Therapeutic angiogenesis using bone marrow-derived mononuclear cell (BM-MNC) implantation has been tested and shown have reasonable efficacy in CLTI. In this multicenter prospective clinical trial, we evaluated safety BM-MNC CLTI with TAO.
Acute mesenteric ischemia is rare, and few large-scale trials have evaluated endovascular therapy (EVT) open surgical revascularization (OS). This study aimed to assess clinical outcomes after EVT or OS for acute superior artery occlusion identify predictors of mortality bowel resection.
Background Many mortality risk scoring tools exist among patients with ST-elevation Myocardial Infarction (STEMI). A stratification model that evaluates STEMI prognosis more simply and rapidly is preferred in clinical practice. Methods Findings We developed a simple for blood examination by using the data of AMI-Kyoto registry derivation set (n = 1,060) assessed its utility prediction validation 521). selected five variables significantly worsen in-hospital mortality: white cell count,...
A 61-year-old man with essential thrombocythemia (ET) presented acute myocardial infarction (AMI) and underwent primary percutaneous coronary intervention. After stent deployment from the left main (LM) to anterior descending artery, intravascular ultrasound revealed thrombi formation in whole stent. Two days later, optical frequency domain imaging confirmed malapposition remaining only LM. The ET might have contributed this phenomenon. He an additional expansion aggressive anti-thrombotic...
Therapeutic angiogenesis with basic fibroblast growth factor (bFGF) atelocollagen was confirmed in a study using limb ischemia mouse model. Because the number of elderly patients critical (CLI) is increasing, particularly that caused by arteriosclerosis obliterans (ASO), development less invasive therapies desired.
Many patients with collagen disease (CD), particularly scleroderma (SSc), develop critical limb ischemia (CLI), which leads to amputation. However, conventional therapies, including revascularization via surgical bypass, showed poor outcomes in CLI CD. SSc responses combination therapies intravenous iloprost, PDE-5 inhibitors, and bosentan. Therefore, new methods of improving the peripheral circulation for salvage are required. This study was a subanalysis long-term clinical after autologous...
Cell-based therapies hold great promise for the treatment of peripheral arterial disease (PAD), especially in patients presenting with severe limb ischemia, although optimal strategy remains to be explored. In this study, we evaluated therapeutic effect intravenous administration human Muse cells, a unique subpopulation mesenchymal stem cells (MSC), using mouse model hindlimb ischemia (HLI) without an immunosuppressant. Compared phosphate buffered saline (PBS) or non-Muse MSC groups, group...
Background Balloon pulmonary angioplasty (BPA) is used for treatment of inoperable chronic thromboembolic hypertension (CTEPH) and residual after endarterectomy (PEA) to improve hemodynamics, right ventricular function, exercise capacity. However, the effectiveness safety guide extension catheters BPA in patients with CTEPH have not been demonstrated. Methods We retrospectively analyzed 91 lesions 55 sessions 28 who underwent using a catheter. The purpose (backup, coaxial, extension),...
Cardiac rupture (CR) is a catastrophic complication of acute myocardial infarction. Primary percutaneous coronary intervention (pPCI) reduces the incidence CR. This study aimed to investigate clinical risk factors and characteristics CR after pPCI.This was retrospective, case-control, multicenter study. We enrolled 2444 consecutive patients with ST-elevation infarction (STEMI) who had undergone pPCI between 2009 2015; 33 experienced (1.35%): 19 were assigned as early (≤72 h) 14 late (>72 h)....
Background:Patients with ST-elevation myocardial infarction (STEMI) who arrive at a hospital via self-transport reportedly have delayed door-to-balloon time (DBT). However, the clinical impacts of DBT on in-hospital mortality among such patients are not well known.
Recently, the limb salvage rate of patients with critical ischemia (CLI) has been improved due to development revascularization and wound care treatment. However, many CLI are refractory standard treatments, including such as endovascular treatment or surgical bypass. Establishment a new cell therapy is required improve prognosis in CLI. In 1997, endothelial progenitor cells were found be derived from bone marrow circulate CD34 surface antigen positive peripheral blood affect therapeutic...
Vasculopathy of systemic sclerosis (SSc) is known to lead severe limb ischemia and often associated with macrovascular diseases. Revascularization proximal lesions that cause in patients SSc has been recommended; however, it rarely reported for below-the-elbow (BTE) involving the palmar artery. A 66-year-old female patient experienced critical hand (CHI) gangrene left third finger failed respond conventional pharmacological treatment. Angiography revealed total occlusion distal radial ulnar...
Background:The combination of a bioresorbable scaffold and antiproliferative drugs is promising treatment for peripheral artery disease. The novel paclitaxel-eluting Igaki-Tamai stent (PTX-ITS) has the same backbone design as drug-free paclitaxel coating. Arterial responses to PTX-ITS ITS using optical coherence tomography (OCT) histological analysis in porcine iliac model were compared.
We report the case of a 62-year-old woman with history bilateral hearing impairment, who developed mitochondrial cardiomyopathy after chemotherapy. The patient underwent postoperative cisplatin chemotherapy surgical treatment cervical cancer. systolic function her left ventricle decreased significantly. A tissue examination revealed cardiomyopathy. Genetic testing mutations in 3,243 A→G. Nine hundred fifty-five individual were identified by next-generation sequencing. Since cardiovascular...
Balloon pulmonary angioplasty (BPA) is an effective treatment for inoperable chronic thromboembolic hypertension (CTEPH). The purpose of this study to evaluate the therapeutic effect and safety non-slip element percutaneous transluminal (NSE PTA) scoring balloons in BPA.108 artery branches 14 CTEPH patients who underwent BPA using NSE PTA balloon (the group) or plain POBA pressure gradient evaluation were analyzed. We compared improvement ratios after (Δ Pressure ratio) both groups.There was...
Background The detrimental repercussions of the COVID-19 pandemic on quality care and clinical outcomes for patients with acute coronary syndrome (ACS) necessitate a rigorous re-evaluation prognostic prediction models in context environment. This study aimed to elucidate adaptability 30-day mortality ACS during periods. Methods A total 2041 consecutive were included from 32 institutions between December 2020 April 2023. dataset comprised who admitted underwent angiography diagnosis...
The recommended revascularisation methods for acute limb ischaemia (ALI), which is caused by embolism and atherosclerotic thrombosis, include endovascular therapy (EVT) open surgical (OSR); however, treatment choices based on patient characteristics remain controversial. This retrospective analysis from the Japanese Registry of All Cardiac Vascular Diseases - Diagnosis Procedure Combination database (April 2012 to March 2020) evaluated differences in clinical outcomes identified prognostic...
Abstract Background The etiology of acute limb ischemia (ALI) involves embolism as well atherosclerotic thrombosis. Although endovascular therapy (EVT) or Fogarty thrombectomy (Fogarty TE) is the recommended revascularization method for ALI, treatment choice based on patient characteristics remains controversial. Purpose This study aimed to evaluate differences in clinical outcomes between primary treatments and identify predictive factors affecting patients with ALI. Methods retrospective...
Abstract Background/Introduction Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors have demonstrated efficacy in lowering low-density lipoprotein cholesterol (LDL-C) levels and reducing the risk of cardiovascular events. Despite these advantages, some patients are unable to continue use PCSK9 due financial or other reasons. Limited clinical studies been conducted investigate outcomes discontinuing for various Purpose This study aims specifically who were inhibitors, with a...
Abstract Background Acute mesenteric ischemia (AMI) is rare, and few large-scale trials have evaluated endovascular therapy (EVT) open surgical revascularisation (OS). This study aimed to assess clinical outcomes after EVT or OS for acute superior artery occlusion (SMAO) identify predictors of mortality bowel resection. Methods Data from the Japanese Registry All Cardiac Vascular Diseases-Diagnosis Procedure Combination database April 2012 March 2020 were retrospectively analyzed. Overall,...