A5032420302- Blood Pressure and Hypertension Studies
- SARS-CoV-2 detection and testing
- Cardiovascular Health and Disease Prevention
- SARS-CoV-2 and COVID-19 Research
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Corneal surgery and disorders
- Cancer Treatment and Pharmacology
- Hematopoietic Stem Cell Transplantation
- Biosensors and Analytical Detection
- Glaucoma and retinal disorders
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- COVID-19 Clinical Research Studies
- Colorectal Cancer Screening and Detection
- Lymphoma Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nutritional Studies and Diet
- Heart Rate Variability and Autonomic Control
- Frailty in Older Adults
- Chemotherapy-related skin toxicity
- Liver Disease Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- Long-Term Effects of COVID-19
Hokkaido University
2018-2025
Hokkaido University of Science
2020-2024
National Center for Global Health and Medicine
2024
Center for Global Health
2024
Sapporo City University
2024
Japan Cancer Society
2024
Kyoto Prefectural University of Medicine
2015-2023
Hokkaido University Hospital
2020-2023
Kyoto University
2022-2023
Hiroshima University Hospital
2023
Patients who have residual invasive carcinoma after the receipt of neoadjuvant chemotherapy for human epidermal growth factor receptor 2 (HER2)-negative breast cancer poor prognoses. The benefit adjuvant in these patients remains unclear.We randomly assigned 910 with HER2-negative (containing anthracycline, taxane, or both) to receive standard postsurgical treatment either capecitabine without (control). primary end point was disease-free survival. Secondary points included overall...
Corneal endothelial cell (CEC) disorders, such as Fuchs's corneal dystrophy, induce abnormal hydration and result in haziness vision loss known bullous keratopathy. We investigated whether injection of cultured human CECs supplemented with a rho-associated protein kinase (ROCK) inhibitor into the anterior chamber could increase CEC density.We performed an uncontrolled, single-group study involving 11 persons who had received diagnosis keratopathy no detectable CECs. Human were from donor...
Objective To investigate the success rate of cold snare polypectomy (CSP) for complete resection 4–9 mm colorectal adenomatous polyps compared with that hot (HSP). Design A prospective, multicentre, randomised controlled, parallel, non-inferiority trial conducted in 12 Japanese endoscopy units. Endoscopically diagnosed sessile polyps, size, were randomly assigned to CSP or HSP group. After removal polyp using allocated technique, biopsy specimens from margin after obtained. The primary...
Abstract The unremitting emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants necessitates ongoing control measures. Given its rapid spread, the new Omicron subvariant BA.5 requires urgent characterization. Here, we comprehensively analyzed with other BA.1, BA.2, and ancestral B.1.1. Although in vitro growth kinetics was comparable among subvariants, much more fusogenic than BA.1 BA.2. Airway-on-a-chip analysis showed that, had enhanced ability to disrupt...
Background There have been limited data examining the age‐dependent relationship of wide‐range risk factors with incidence each subtype cardiovascular disease (CVD) event. We assessed age‐related associations between modifiable and CVD. Methods Results analyzed 3 027 839 participants without a CVD history enrolled in JMDC Claims Database (mean age, 44.8±11.0 years; 57.6% men). Each participant was categorized as aged 20 to 49 years (n=2 008 559), 50 59 (n=712 273), 60 75 (n=307 007). Using...
Objective: The impact of age on survival after hepatic resection for hepatocellular carcinoma (HCC) has not been thoroughly examined. We reviewed the data a nationwide follow-up survey to determine outcomes hepatectomy HCC in elderly patients. Background: Management malignant diseases patients become global clinical issue because increased life expectancy worldwide. Advancements surgical techniques and perioperative management have reduced age-related contraindications liver surgery....
In randomized clinical trials, multiple-testing procedures, composite endpoints, and prioritized outcome approaches are increasingly used to analyze multiple binary outcomes. Previous studies have shown that correlations between outcomes influence their sample size requirements. Although is an important factor affecting the choice of statistical methods, power required sizes methods for analyzing yet be compared under correlations.
Background:Bone metastasis (BM) is a frequent complication in patients with advanced lung cancer and it causes skeletal-related events (SREs). Our study aim to prospectively investigate the incidence of BM, types SRE, predictive factors BM SREs.Methods:Newly diagnosed, non–small-cell (NSCLC) or small-cell (SCLC) were enrolled into study. Patients followed up every 4 weeks monitor development SREs. Treatment for was performed at discretion investigator.Results:Two hundred seventy-four this...
The significance of examination time esophagogastroduodenoscopy (EGD) for asymptomatic examinees is yet to be established. We aimed clarify whether endoscopists who allot more can detect higher numbers neoplastic lesions among examinees.We reviewed a database consecutive underwent EGD in our hospital from April 2010 September 2015. Staff were classified into fast, moderate, and slow groups based on the mean without biopsy. Neoplastic lesion detection rate these was compared using multiple...
Recently, the efficacy of cryotherapy and compression therapy to prevent taxane-induced peripheral neuropathy has been reported. We prospectively compared using a frozen glove (FG) surgical (SG) nanoparticle albumin-bound paclitaxel (nab-PTX)-induced neuropathy.Breast cancer patients who received 260 mg/m2 nab-PTX were eligible participate in this trial. Patients wore FG on one hand (60 min) without changing two SGs same size (i.e., smaller than that best fit their hand) other (90 during...
Physical performance measures (PPMs) are good predictors of adverse health outcomes in later life. This prospective study used repeated analysis to examine sex-specific age trends PPMs, identify potential PPM trajectory patterns, and determine whether patterns were associated with all-cause mortality among older Japanese. Among 1,524 adults aged 65 years or who participated a baseline survey, 1,048 (mean [ SD ] age, 71.6 [5.4] years; women, 57.0%) followed up at least once. The total number...
Abstract Background COVID-19 has rapidly evolved to become a global pandemic due largely the transmission of its causative virus through asymptomatic carriers. Detection SARS-CoV-2 in people is an urgent priority for prevention and containment disease outbreaks communities. However, few data are available persons regarding accuracy PCR testing. Additionally, although self-collected saliva significant logistical advantages mass screening, utility as alternative specimen yet be determined....
Abstract Emerging evidences have shown the utility of saliva for detection SARS-CoV-2 by PCR as alternative to nasopharyngeal swab (NPS). However, conflicting results been reported regarding viral loads between NPS and saliva. We conducted a study compare in 42 COVID-19 patients. Viral were estimated cycle threshold (Ct) values. was detected 34 (81%) using with median Ct value 27.4, 38 (90%) 28.9 (P = 0.79). Kendall’s W 0.82, showing high degree agreement, indicating equivalent After symptom...
447 Background: Ramucirumab (RAM) has shown efficacy in combination with paclitaxel (PTX) or irinotecan the second-line treatment of advanced gastric cancer (AGC). However, and safety regarding therapy RAM docetaxel (DTX) have not been reported. We hypothesized that plus DTX for patients AGC could be as effective PTX reduce incidence neuropathy. Methods: HGCSG 1903 was a non-randomized, single arm, phase 2 trial carried out at 20 institutes Japan. refractory intolerance to primary...
589 Background: It has been reported that there are BRCA1/2 -mutated patients in biliary tract, pancreatic, and other gastrointestinal cancers. Niraparib is a poly(ADP-ribose) polymerase (PARP) inhibitor, PARP inhibitors exert their cytotoxicity against cancer cells the context of homologous recombination deficiency, such as BRCA mutations. Methods: Main eligibility criteria unresectable, advanced or recurrent tract cancers (BTC; cohort A), pancreatic (PC; B), (cohort C) with gene mutations...
Introduction The Ministry of Health, Labour, and Welfare Japan (MHLW) introduced a regulation on physician overtime work in 2024, limiting hours to maximum 960 annually. This has raised concerns that the quality medical care may decline. On other hand, shifting demographics Japan, characterized by an aging population declining birth rates, suggest potential decrease demand for obstetrics gynecology (OBGYN) services future. In there is no feasible study regarding how many OBGYN doctors are...
Abstract Background Patients (pts) with pathologic residual invasive disease after neoadjuvant chemotherapy (NAC) have an intermediate or high-risk for relapse. It is not clear whether further systemic beneficial these pts. CREATE-X a multicenter open-label randomized phase III trial evaluating this major clinical issue using capecitabine (X) in pts without pCR NAC (UMIN000000843). We shown previously that the addition of 8 cycles X to standard adjuvant therapy feasible and well tolerated...