A5029687156- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Drug-Induced Adverse Reactions
- Retinal Diseases and Treatments
- Ocular Infections and Treatments
- Urticaria and Related Conditions
- Ocular Diseases and Behçet’s Syndrome
- Ocular Disorders and Treatments
- Intraocular Surgery and Lenses
- Contact Dermatitis and Allergies
- Immune Response and Inflammation
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Mast cells and histamine
- Ophthalmology and Visual Impairment Studies
- Allergic Rhinitis and Sensitization
- Connexins and lens biology
- Ophthalmology and Eye Disorders
- Autoimmune Bullous Skin Diseases
- Advanced Glycation End Products research
- Retinal and Macular Surgery
- Skin Protection and Aging
- Ocular Oncology and Treatments
Kyoto Prefectural University of Medicine
2016-2025
The University of Tokyo
2009-2024
Kyoto University
1996-2021
Frontier Medical College
2015-2020
Weatherford College
2020
Ophthalmology Associates (United States)
2018-2020
Kyoto Prefectural University
2001-2017
Massachusetts Eye and Ear Infirmary
1984-2017
Harvard University
1996-2017
Smith-Kettlewell Eye Research Institute
2015-2017
Purpose: To update the 2008 International Classification of Corneal Dystrophies (IC3D) incorporating new clinical, histopathologic, and genetic information. Methods: The IC3D reviewed worldwide peer-reviewed articles for information on corneal dystrophies published between 2014. Using this information, dystrophy templates anatomic classification were updated. New confocal photographs added. Results: On basis revisiting cellular origin dystrophy, a modified is proposed consisting (1)...
Corneal endothelial cell (CEC) disorders, such as Fuchs's corneal dystrophy, induce abnormal hydration and result in haziness vision loss known bullous keratopathy. We investigated whether injection of cultured human CECs supplemented with a rho-associated protein kinase (ROCK) inhibitor into the anterior chamber could increase CEC density.We performed an uncontrolled, single-group study involving 11 persons who had received diagnosis keratopathy no detectable CECs. Human were from donor...
Introduction: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 HLA-B*5801 with carbamazepine- allopurinol-induced reactions were found in Han Chinese patients, respectively, ethnic differences the have been reported. The objective this study is to clarify involvement Japanese SJS/TEN patients. Methods: HLA-B genotyping was performed on 58 patients between July 2006...
purpose. The transplantation of cultivated corneal endothelial cells (CECs) has gained attention recently for the treatment patients with dysfunction. However, an efficient culturing technique human (H)CECs yet to be properly established. present study was conducted investigate applicability Rho kinase (ROCK) inhibitor Y-27632 in promoting cultivation cynomolgus monkey (M)CECs. methods. MCECs monkeys were cultured a medium containing 10 μM Y-27632. number viable adherent culture plates...
To evaluate the effect of Rho kinase (ROCK)-inhibitor eye drops on a corneal endothelial dysfunction primate model and human clinical case series dysfunction.As corneal-endothelial partially injured model, endothelium seven cynomolgus monkeys was damaged by transcorneal freezing; 10 mm rock inhibitor Y-27632 then applied topically 6 times daily. The phenotype reconstructed evaluated immunohistochemical analysis noncontact specular microscopy. For study, after freezing in eight patients: four...
Abstract The corneal endothelium maintains transparency; consequently, its dysfunction causes severe vision loss. Tissue engineering-based therapy, as an alternative to conventional donor transplantation, is anticipated provide a less invasive and more effective therapeutic modality. We conducted preclinical study for cell-based therapy in primate model demonstrated regeneration of the following injection cultured monkey endothelial cells (MCECs) or human CECs (HCECs), combination with Rho...
purpose. It would be advantageous if cultivated human corneal endothelial cells (cHCECs) could transplanted for the treatment of diseases caused by disorders. To achieve this, a matrix that can serve as carrier cHCECs is needed. The present study was conducted to examine feasibility using amniotic membrane (AM) this application. methods. HCECs obtained from peripheral tissue were cultivated, passaged, and onto denuded AM. cell density morphology resultant on AM examined light, scanning...
purpose. To determine the feasibility of using human amniotic membrane (AM) as a substrate for culturing oral epithelial cells and to investigate possibility autologous cultivated in ocular surface reconstruction. methods. An injury was created one eye each eight adult albino rabbits by lamellar keratectomy, conjunctival excision performed, including extending 5 mm outside limbus. Oral mucosal biopsy specimens were obtained from these 3 weeks on denuded AM carrier. The epithelium examined...