A5051060008- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Intraocular Surgery and Lenses
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Connexins and lens biology
- Ocular Infections and Treatments
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Proteoglycans and glycosaminoglycans research
- Urticaria and Related Conditions
- TGF-β signaling in diseases
- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Anorectal Disease Treatments and Outcomes
- Wound Healing and Treatments
- Wnt/β-catenin signaling in development and cancer
- Advanced Glycation End Products research
- Optical Coherence Tomography Applications
- Healthcare and Venom Research
- Tissue Engineering and Regenerative Medicine
- Silk-based biomaterials and applications
- Allergic Rhinitis and Sensitization
Duke University
2024
Seoul St. Mary's Hospital
2014-2023
Catholic University of Korea
2014-2023
Kim's Eye Hospital
2009-2023
St. Mary's Health Center
2022
Eye Center
2022
Yeouido St. Mary's Hospital
2015-2020
Nune Eye Hospital
2017-2020
St Mary's Hospital
2019-2020
Keimyung University
2015-2017
Axin2/Conductin/Axil and its ortholog Axin are negative regulators of the Wnt signaling pathway, which promote phosphorylation degradation -catenin.While is expressed ubiquitously, Axin2 mRNA was seen in a restricted pattern during mouse embryogenesis organogenesis.Because many sites expression overlapped with those several genes, we tested whether induced by signaling.Endogenous protein could be rapidly activation reporter constructs, containing 5.6-kbDNA fragment including promoter first...
We demonstrate smart contact lenses for noninvasive and continuous diabetic diagnosis retinopathy therapy.
Smart contact lenses for continuous glucose monitoring (CGM) have great potential huge clinical impact. To date, their development has been limited by challenges in accurate detection of without hysteresis tear to track the blood levels. Here, long-term robust CGM diabetic rabbits is demonstrated using bimetallic nanocatalysts immobilized nanoporous hydrogels smart lenses. After redox reaction oxidase, facilitate rapid decomposition hydrogen peroxide and nanoparticle-mediated charge transfer...
Abstract Glaucoma is one of the irreversible ocular diseases that can cause vision loss in some serious cases. Although Triggerfish has been commercialized for monitoring intraocular pressure glaucoma, there no smart contact lens to monitor and take appropriate drug treatment response levels. Here, we report a precisely integrated theranostic with sensitive gold hollow nanowire based sensor, flexible delivery system, wireless power communication systems an application specific circuit chip...
To determine cytokine and chemokine concentrations in the tears of patients with dry eye disease (DED) analyze possible relationships clinical severity DED.Patients were examined using Ocular Surface Disease Index, corneal conjunctival staining, tear breakup time, impression cytology. They divided into four groups according to Dry Eye Workshop classification. Tears collected from 133 DED 70 healthy controls. Concentrations cytokines, chemokines, soluble receptors samples analyzed current...
Purpose: To determine the relationship between dry eye disease (DED) and depressive symptoms in a nationally representative sample of Korean women. Methods: This population-based cross-sectional study comprised 6655 women (aged 19 years or older) participating fifth annual Korea National Health Nutrition Examination Survey from 2010 to 2011. Psychological problems associated with clinically diagnosed DED by ophthalmologists were assessed using questionnaires surveys. Data analyzed logistic...
Diabetic retinopathy is currently treated by highly invasive repeated therapeutic injections and surgical interventions without complete vision recovery. Here, a noninvasive smart wireless far red/near-infrared (NIR) light emitting contact lens developed successfully for the treatment of diabetic with significantly improved compliance. A red/NIR diode (LED) connected an application-specific integrated circuit chip, power, communication systems on PET film, which embedded in silicone...
There are several methods for early diagnosis of tumors, such as detecting circulating tumor DNAs, cells, or imaging with tumor-targeting contrast agents. However, these assays time-consuming and may cause patient discomfort during the biopsy collecting process. Here, we develop a facile method tumors by extracting exosomes from interstitial fluid (ISF) using hydrogel microneedles (MNs). The MNs expand in skin to absorb ISF, contained ISF bind glypican-1 antibodies inside MNs. After removing...
Purpose: To evaluate the progressive constriction of anterior capsule opening that can occur after continuous curvilinear capsulorhexis (CCC). Setting: Kangnam St. Mary's Hospital, Seoul, Korea. Methods: Changes in CCC were evaluated 166 pseudophakic eyes at 1 week and 3 months postoperatively. The capsular diameter was measured with an image analysis system. Results: reduced by average 13.87% CCC. There more dense opacity than posterior capsule. Lens epithelial cells (LECs) main cause...
A contact lens is an attractive tool for the delivery of ophthalmic drugs, but it has several issues such as burst release drugs and limited drug loading capacity. To overcome these limitations, we developed a cholesterol-hyaluronate (C-HA) micelle-embedded efficient hydrophobic long-term controlled delivery. The was fabricated via photopolymerization hydroxyethyl methacrylate (HEMA) using ethylene glycol dimethacrylate (EGDMA) cross-linker. C-HA micelle-loaded showed statistically...
To evaluate the expression of vascular endothelial growth factor (VEGF) in pterygium and investigate interrelationships between VEGF nitric oxide (NO) development pterygia.Specimens normal conjunctiva acquired incidentally to conjunctival transplantation during strabismus surgery excised were used this study. Cryopreserved tissue specimens consisting study inducible NO synthetase (iNOS), using immunohistochemistry. For confirmation NOS activity, reduced nicotinamide adenine dinucleotide...
We report 2 cases of corneal ectasia detected after laser in situ keratomileusis (LASIK) for the correction less than -12.0 diopters (D) myopia. Patients were evaluated before and LASIK by topography pachymetry. After treatment, visual acuity temporarily improved but was followed impairment, with topography. There may be a risk myopia D. Despite thelow incidence, we recommend that restricted to which more half original thickness 250 microns stromal bed can preserved. Careful examination,...
TGFbeta is a potent candidate for epithelial-mesenchymal transition (EMT) during the development of anterior polar cataracts in human lens. The Snail superfamily involved EMT through repression E-cadherin production. This study was conducted to determine whether gene family activated process TGFbeta1-induced and how TGFbeta1 regulates expression this family.Total RNA extracted from cataract samples subjected real-time PCR quantification Slug mRNA. Induction by (10 ng/mL) lens epithelial...
The purposes of this study were to determine the normal ocular bacterial flora isolated from patients undergoing anterior segment surgery and evaluate their in vitro susceptibility ciprofloxacin, levofloxacin, gatifloxacin, moxifloxacin.During January 2006 December 2006, conjunctival swabs taken 385 eyes inoculated onto 5% blood agar plates. bacteria classified by analysis 16s ribosomal DNA sequencing. Disk diffusion testing was performed accordance with Clinical Laboratory Standards...
Purpose To measure miosis after femtosecond laser pretreatment of cataract surgery and determine correlative factors. Setting Department Ophthalmology Visual Science, Seoul St. Mary's Hospital, College Medicine, Catholic University Korea, Seoul, South Korea. Design Cross-sectional study. Methods Images extracted from surgical videos phacoemulsification were used to the pupil area. Quantitative analysis constriction was performed by comparing consecutive images obtained at initiation each...
Lymphangiogenesis is one of the major causes corneal graft rejection. Among lymphangiogenic factors, vascular endothelial growth factor (VEGF)-C and -D are considered to be most potent. Both bind VEGF receptor 3 (VEGFR3) activate Prospero homeobox 1 (Prox1), a transcription essential for development maintenance lymphatic vasculature. MicroRNAs (miRNAs) 3' untranslated regions (3' UTRs) target genes in sequence-specific manner suppress gene expression. In current study, we searched miRNAs...
Diquafosol is known as a purinergic P2Y2 receptor (P2Y2R) agonist that stimulates water and mucin secretion from conjunctival epithelial cells goblet cells, leading to tear film stability in dry eye. However, its effect on corneal healing has not yet been elucidated. The aim of the present study was evaluate diquafosol vivo P2Y2R-related downstream signaling pathways vitro. We administered 3% ophthalmic solution 3 mm-diameter defects made rat corneas assessed wound closure over time. Corneal...