A5023858699- Vibrio bacteria research studies
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Metabolism, Diabetes, and Cancer
- Bacterial biofilms and quorum sensing
- Tea Polyphenols and Effects
- Education and Learning Interventions
- Cell Adhesion Molecules Research
- Nitric Oxide and Endothelin Effects
- Retinoids in leukemia and cellular processes
- Aquaculture disease management and microbiota
- Atherosclerosis and Cardiovascular Diseases
- Diet, Metabolism, and Disease
- Autophagy in Disease and Therapy
- Brucella: diagnosis, epidemiology, treatment
- Protein Kinase Regulation and GTPase Signaling
- Extracellular vesicles in disease
- Psychosocial Factors Impacting Youth
- Connective Tissue Growth Factor Research
- Genetics and Neurodevelopmental Disorders
- Angiogenesis and VEGF in Cancer
- Chemokine receptors and signaling
University of Alabama at Birmingham
2015-2025
St. Vincent's Hospital
2023-2025
Dong-A University
2022-2024
Government of the Republic of Korea
2024
Catholic University of Korea
2002-2023
Eunpyeong Hospital
2023
McLean Hospital
2023
Harvard University
2023
University of Alabama
2022
Sogang University
2013-2021
Epigallocatechin gallate (EGCG), a bioactive polyphenol in green tea, may augment metabolic and vascular actions of insulin. Therefore, we investigated effects EGCG treatment to simultaneously improve cardiovascular function spontaneously hypertensive rats (SHR; model syndrome with hypertension, insulin resistance, overweight). In acute studies, (1-100 microM) elicited dose-dependent vasodilation mesenteric beds (MVB) isolated from SHR ex vivo that was inhibitable by...
Hesperidin, a citrus flavonoid, and its metabolite hesperetin may have vascular actions relevant to their health benefits. Molecular physiological mechanisms of are unknown.We tested whether stimulates production nitric oxide (NO) from endothelium evaluated endothelial function in subjects with metabolic syndrome on oral hesperidin therapy. DESIGN, SETTING, AND INTERVENTIONS: Cellular action were bovine aortic cells (BAEC) primary culture. A randomized, placebo-controlled, double-blind,...
Green tea consumption is associated with reduced cardiovascular mortality in some epidemiological studies. Epigallocatechin gallate (EGCG), a bioactive polyphenol green tea, mimics metabolic actions of insulin to inhibit gluconeogenesis hepatocytes. Because signaling pathways regulating and vasodilator are shared common, we hypothesized that EGCG may also have stimulate production nitric oxide (NO) from endothelial cells. Acute intra-arterial administration mesenteric vascular beds isolated...
Epigallocatechin gallate (EGCG) is a major polyphenol in green tea that has beneficial effects the prevention of cardiovascular disease. Autophagy cellular process protects cells from stressful conditions. To determine whether effect EGCG mediated by mechanism involving autophagy, roles EGCG-stimulated autophagy context ectopic lipid accumulation were investigated. Treatment with increased formation LC3-II and autophagosomes primary bovine aortic endothelial (BAEC). Activation...
Elevated tissue levels of angiotensin II (ANG II) are associated with impairment insulin actions in metabolic and cardiovascular tissues. ANG II-stimulated activation mammalian target rapamycin (mTOR)/p70 S6 kinase (p70S6K) tissues is implicated cardiac hypertrophy vascular remodeling. However, the role mTOR/p70S6K endothelium poorly understood. In present study, we observed that stimulated p70S6K bovine aortic endothelial cells. increased phosphorylation receptor substrate-1 (IRS-1) at Ser...
Insulin resistance is associated with obesity and may be accompanied by left ventricular diastolic dysfunction myocardial remodeling. Decreased insulin metabolic signaling increased oxidative stress promote these maladaptive changes. In this context, the beta-blocker nebivolol has been reported to improve sensitivity, increase endothelial NO synthase activity, reduce NADPH oxidase-induced superoxide generation. We hypothesized that would attenuate remodeling blunting oxidant promoting in a...
Epigallocatechin gallate (EGCG), a green tea polyphenol, promotes vasodilation by phosphatidylinositol 3-kinase-dependent activation of Akt and endothelial nitric oxide synthase to stimulate production oxide. Reduction in endothelin-1 (ET-1) synthesis may also increase bioavailability We hypothesized that the transcription factor FOXO1 mediate effects EGCG regulate expression ET-1 cells. treatment (10 microm, 8 h) human aortic cells reduced mRNA, protein, secretion. identified putative FOXO...
Insulin resistance, a hallmark of metabolic disorders, is risk factor for diabetes and cardiovascular disease. Impairment insulin responsiveness in vascular endothelium contributes to resistance. The reciprocal relationship between resistance endothelial dysfunction augments the pathophysiology metabolism functions. most abundant green tea polyphenol, epigallocatechin-3-gallate (EGCG), has been shown have vasodilator action vessels by activation nitric oxide synthase (eNOS). However, it not...
Extracellular polysaccharides, such as lipopolysaccharide and loosely associated exopolysaccharides, are essential for Vibrio vulnificus to form biofilms. The role of another major component the V. extracellular matrix, capsular polysaccharide (CPS), which contributes colony opacity, has been characterized in biofilm formation. A CPS-deficient mutant, whose wbpP gene encoding UDP-GlcNAc C4-epimerase was knocked out, formed significantly more than wild type, due increased hydrophobicity cell...
Abstract Autophagy, an integral part of the waste recycling process, plays important role in cellular physiology and pathophysiology. Impaired autophagic flux causes ectopic lipid deposition, which is defined as accumulation lipids non-adipose tissue. Ectopic observed patients with cardiometabolic syndrome, including obesity, diabetes, insulin resistance, cardiovascular complications. Metformin first line treatment for type 2 one underlying mechanisms anti-diabetic effect metformin mediated...
Ghrelin is an orexigenic peptide hormone secreted by the stomach. In patients with metabolic syndrome and low ghrelin levels, intra-arterial administration acutely improves their endothelial dysfunction. Therefore, we hypothesized that activates nitric oxide synthase (eNOS) in vascular endothelium, resulting increased production of (NO) using signaling pathways shared common insulin receptor. Similar to insulin, stimulated NO bovine aortic cells (BAEC) primary culture (assessed NO-specific...
Dehydroepiandrosterone (DHEA) is an adrenal steroid and nutritional supplement that may improve insulin sensitivity. Although hormones classically act by regulating transcription, they also signal through cell surface receptors to mediate nongenomic actions. Because DHEA augment sensitivity, we hypothesized mimics vascular actions of acutely activate signaling pathways in endothelium-mediating production nitric oxide (NO) endothelin 1 (ET-1). Treatment bovine aortic endothelial cells with...
Glucagon receptor (GCGR) agonists cause hyperglycemia but also weight loss. However, GCG-like peptide 1 (GLP1R)/GCGR mixed do not exhibit the diabetogenic effects often attributed to GCGR activity. Thus, we sought investigate effect of glucagon agonism on insulin action and glucose homeostasis. Acute induced immediate hyperglycemia, followed by improved tolerance enhanced glucose-stimulated secretion. Moreover, acute in a dose-dependent manner both lean obese mice. Improved was independent...
Impairment of vasodilator action insulin is associated with endothelial dysfunction and resistance. Activation Toll-like receptor 4 (TLR4) induces proinflammatory response endoplasmic reticulum (ER) stress. Saturated fatty acids (SFA) activate TLR4, which ER stress dysfunction. Therefore, we determined whether TLR4-mediated an obligatory step mediating SFA-induced Palmitate stimulated responses stress, this was suppressed by knockdown TLR4 in primary human aortic cells (HAEC). Next, examined...
Inflammation contributes to insulin resistance in diabetes and obesity. Mouse Pelle-like kinase (mPLK, homolog of human IL-1 receptor-associated (IRAK)) participates inflammatory signaling. We evaluated IRS-1 as a novel substrate for mPLK that may contribute linking inflammation with resistance. Wild-type mPLK, but not kinase-inactive mutant (mPLK-KD), directly phosphorylated full-length vitro. This vitro phosphorylation was increased when immunoprecipitated from tumor necrosis factor...
Obesity is characterized by a chronic proinflammatory state that leads to endothelial dysfunction. Saturated fatty acids (SFA) stimulate Toll-like receptors (TLR) promote metabolic insulin resistance. However, it not known whether TLR2 mediates impairment of vascular actions in response high-fat diet (HFD) cause siRNA knockdown primary cells opposed palmitate-stimulated expression cytokines and splicing X box protein 1 (XBP-1). Inhibition unfolding (UPR) reduced SFA-stimulated TNFα. Thus,...