A5101857164- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Economic Growth and Productivity
- Regional Economics and Spatial Analysis
- Regional Economic and Spatial Analysis
- Global trade and economics
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Biochemical Analysis and Sensing Techniques
- Fiscal Policy and Economic Growth
- Cardiac Imaging and Diagnostics
- Lipid metabolism and disorders
- Liver physiology and pathology
- Cardiovascular Disease and Adiposity
- Metabolism, Diabetes, and Cancer
- Endoplasmic Reticulum Stress and Disease
- Sustainable Industrial Ecology
- Retinal Diseases and Treatments
- Diverse Aspects of Tourism Research
- Endometriosis Research and Treatment
- Sustainable Development and Policies
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Receptor Mechanisms and Signaling
Oklahoma State University
2021-2025
Renji Hospital
2018-2025
Shanghai Jiao Tong University
2018-2025
In-Q-Tel
2024
Hunan University of Humanities, Science and Technology
2024
Jilin Academy of Agricultural Sciences
2024
Chongqing University
2024
Johns Hopkins University
2012-2021
Johns Hopkins Medicine
2012-2021
China-Japan Friendship Hospital
2021
Transgenic overexpression of CTRP9, a secreted hormone downregulated in obesity, confers striking protection against diet-induced obesity and type 2 diabetes. However, the physiological relevance this adiponectin-related plasma protein remains undefined. Here, we used gene targeting to establish metabolic function CTRP9 context. Mice lacking were obese gained significantly more body weight when fed standard laboratory chow. Increased food intake, due part upregulated expression hypothalamic...
Longitudinally oriented microstructures are essential for a nerve scaffold to promote significant regeneration of injured peripheral axons across gaps. Extensive attention has been devoted develop scaffolds with inner structures mimicking the nerve-guiding basal lamina microchannels in autografts. However, date, little information obtained about similar microstructures, and efficacy such bridging gaps vivo never examined. In present study, we describe novel collagen-chitosan (CCH) dimensions...
C1q/TNF-related protein 1 (CTRP1) is a conserved plasma of the C1q family with notable metabolic and cardiovascular functions. We have previously shown that CTRP1 infusion lowers blood glucose transgenic mice elevated circulating are protected from diet-induced obesity insulin resistance. Here, we used genetic loss-of-function mouse model to address requirement for homeostasis. Despite similar body weight, food intake, energy expenditure, Ctrp1 knockout (KO) fed low-fat diet developed...
We recently described myonectin (also known as erythroferrone) a novel skeletal muscle-derived myokine with metabolic functions. Here, we use genetic mouse model to determine myonectin's requirement for homeostasis. Female myonectin-deficient mice had larger gonadal fat pads and developed mild insulin resistance when fed high-fat diet (HFD) reduced food intake during refeeding after an unfed period but were otherwise indistinguishable from wild-type littermates. Male lacking myonectin,...
To evaluate the protective effect of intravitreal injection exendin-4 analogue (E4a) in early diabetic retinopathy (DR) and to explore its possible mechanism.Forty Sprague-Dawley rats were divided into three groups: normal (N), (D), E4a-treated (E4a). Diabetes was induced by streptozotocin. Rats E4a group treated with (0.1 μg/2μL/eye), whereas N D groups equivalent volume saline. Electroretinography performed at 1 month 3 months after diabetes onset. Thicknesses cell counts each layer retina...
CTRP4 is a unique member of the C1q family, possessing two tandem globular domains. Its physiological function poorly defined. Here, we show that an evolutionarily conserved, ∼34-kDa secretory protein expressed in brain. In human, mouse, and zebrafish brain, expression begins early development widespread central nervous system. Neurons, but not astrocytes, express secrete CTRP4, secreted proteins form higher-order oligomeric complexes. also produced by peripheral tissues circulates blood....
C1q/TNF-related protein 3 (CTRP3) is a secreted metabolic regulator whose circulating levels are reduced in human and rodent models of obesity diabetes. Previously, we showed that CTRP3 infusion lowers blood glucose by suppressing gluconeogenesis transgenic overexpression protects mice against diet-induced hepatic steatosis. Here, used genetic loss-of-function mouse model to further address whether indeed required for homeostasis under normal obese states. Both male female lacking had...
Chronic low-grade inflammation and cellular stress are important contributors to obesity-linked metabolic dysfunction. Here, we uncover an immune-metabolic role for C1q/TNF-related protein 7 (CTRP7), a secretory of the C1q family with previously unknown function. In obese humans, circulating CTRP7 levels were markedly elevated positively correlated body mass index, glucose, insulin, insulin resistance hemoglobin A1c, triglyceride levels. Expression in liver was also significantly upregulated...
C1q/TNF-related protein 3 (CTRP3) is a secreted hormone that modulates hepatic glucose and lipid metabolism. Its circulating levels are reduced in human rodent models of obesity, metabolic state accompanied by chronic low-grade inflammation. Recent studies have demonstrated an anti-inflammatory role for recombinant CTRP3 attenuating LPS-induced systemic inflammation, its deficiency markedly exacerbates inflammation mouse model rheumatoid arthritis. We used genetic to explore the...
The gene that encodes C1q/TNF-related protein 5 (CTRP5), a secreted of the C1q family, is mutated in individuals with late-onset retinal degeneration. CTRP5 widely expressed outside eye and also circulates plasma. Its physiological role peripheral tissues, however, has yet to be elucidated. Here, we show Ctrp5 expression modulated by fasting refeeding, different diets, mice. Adipose was markedly upregulated obese diabetic humans genetic dietary models obesity rodents. Furthermore, human...
Adipose tissue-derived adipokines are an important class of secreted metabolic regulators that mediate tissue cross-talk to control systemic energy balance. We recently described C1q/TNF-related protein-12 (CTRP12), a novel insulin-sensitizing adipokine regulates glucose metabolism in liver and adipose tissue. However, the biochemical properties CTRP12 its naturally occurring cleaved isoform have not been characterized. Here, we show is hormone subjected multiple functionally relevant...
Acute aortic dissection (AAD) is a catastrophic event with high early mortality rate, but to date, no data on the incidence of AAD in Mainland China available. This study aimed estimate and characterize clinical profile, management in-hospital outcomes this vascular event.
Exercise is known to confer major health benefits, but the underlying mechanisms are not well understood. The systemic effects of exercise on multi-organ systems thought be partly because myokines/cytokines secreted by skeletal muscle. extent which alters cytokine expression and secretion in different muscle fiber types has been systematically examined. Here, we assessed changes 66 mouse cytokines serum, glycolytic (plantaris) oxidative (soleus) muscles, response sprint, endurance, or...
The highly conserved C1q/TNF-related protein (CTRP) family of secreted hormones has emerged as important regulators insulin action and sugar fat metabolisms. Among these, the specific biological function CTRP2 remains elusive. Here, we show that expression human is positively correlated with body mass index (BMI) up-regulated in obesity. We used a knockout (KO) mouse model to determine found Ctrp2-KO mice have significantly elevated metabolic rates energy expenditure leading lower weights...
Previous genome-wide association studies have linked three missense single nucleotide polymorphisms (SNPs) in C1q/TNF-related protein 6 (CTRP6) to diseases such as type 1 diabetes and autoimmune diseases. However, the potential of newly identified CTRP6 variants with diseases, especially cancer, remains unclear. We used several pathogenicity prediction algorithms identify deleterious mutations within highly conserved C1q domain human CTRP6, following retrieval all SNPs from Ensembl database....
Background: Dietary consumption of insulinogenic amino acids (IAA) is known to contribute the development insulin resistance. It remains be studied whether dietary IAA restriction improves glucose metabolism and sensitivity this improvement related alterations in peripheral tissues. The objective study was examine effect on a piglet model. Methods: Following acclimation period, thirty-two seven-day-old male piglets were randomly assigned into one three groups for weeks as follows (n =...