A5037604705- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Nitric Oxide and Endothelin Effects
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Apelin-related biomedical research
- Biochemical Analysis and Sensing Techniques
- Heart Rate Variability and Autonomic Control
- Liver Disease Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Diet, Metabolism, and Disease
- Renin-Angiotensin System Studies
- Lipoproteins and Cardiovascular Health
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiac electrophysiology and arrhythmias
- Cancer, Lipids, and Metabolism
- Pancreatic function and diabetes
University of Rome Tor Vergata
2016-2025
Policlinico Tor Vergata
2009-2023
A. O. Ordine Mauriziano di Torino
2021
ORCID
2020
Laboratoire de Chimie
2020
Agostino Gemelli University Polyclinic
2017
Sapienza University of Rome
2013
Università Cattolica del Sacro Cuore
2005-2006
Istituti di Ricovero e Cura a Carattere Scientifico
2006
National Heart Lung and Blood Institute
2005
An endothelial nitric oxide synthase (eNOS) polymorphism in exon 7 (894 G/T) resulting glutamate or aspartate, respectively, at position 298 on the protein is correlated with severity of cardiopulmonary diseases. Because and aspartate are considered to be conservative replacements, was thought a marker for functional locus elsewhere gene. We now show transfected cells, primary human hearts, that eNOS but not glutamate, cleaved, generation 100-kDa 35-kDa products. Recombinant native examined...
Hesperidin, a citrus flavonoid, and its metabolite hesperetin may have vascular actions relevant to their health benefits. Molecular physiological mechanisms of are unknown.We tested whether stimulates production nitric oxide (NO) from endothelium evaluated endothelial function in subjects with metabolic syndrome on oral hesperidin therapy. DESIGN, SETTING, AND INTERVENTIONS: Cellular action were bovine aortic cells (BAEC) primary culture. A randomized, placebo-controlled, double-blind,...
Metabolic syndrome importantly accelerates the atherosclerotic process, earliest event of which is endothelial dysfunction. Ghrelin, a gastric peptide with cardiovascular actions, has been shown to inhibit proatherogenic changes in experimental models. This study therefore investigated whether ghrelin administration might beneficially affect function metabolic syndrome.Endothelium-dependent and -independent vasodilator responses intra-arterial infusion increasing doses acetylcholine sodium...
Cognitive decline significantly contributes to disability in older individuals. We previously demonstrated cross-sectionally that arterial stiffness [pulse wave velocity (PWV)] was associated with memory loss independently of traditional cardiovascular risk factors and neuroimaging findings individuals without prior stroke. The present study aimed evaluate PWV as a predictor longitudinal changes cognitive function reporting problems.We studied 102 (mean age 79 +/- 6 years; 31 men, 71 women)...
Enhanced oxidative stress contributes to the pathogenesis of diabetes and its complications. Peroxiredoxin 6 (PRDX6) is a key regulator cellular redox balance, with peculiar ability neutralize peroxides, peroxynitrite, phospholipid hydroperoxides. In current study, we aimed define role PRDX6 in pathophysiology type 2 (T2D) using knockout (-/-) mice. Glucose insulin responses were evaluated respectively by intraperitoneal glucose tolerance tests. Peripheral sensitivity was analyzed...
Flavonoids display a broad range of structures and are responsible for the major organoleptic characteristics plant-derived foods beverages. Recent data showed their activity, in particular luteolin-7-O-glucoside (LUT-7G), reduction oxidative stress inflammatory mechanisms different physiological systems. In this paper, we tried to elucidate how LUT-7G could exert both antioxidant anti-inflammatory effects endothelial cells cultured vitro. Here, that is able inhibit STAT3 pathway, have an...
Soluble CD40L (sCD40L), a substance that maximally reflects in vivo platelet activation, is increased patients with hypercholesterolemia. We investigated the relation between sCD40L and CD4OL hypercholesterolemic before after short-term treatment atorvastatin.Collagen-induced plasma levels of prothrombin fragment F1+2, marker thrombin generation, were 30 20 healthy subjects. Hypercholesterolemic then randomized to either diet (n=15; group A) or atorvastatin 10 mg/d (group B); aforementioned...
Obesity is associated with endothelial dysfunction related to decreased NO bioavailability, increased endothelin 1 vasoconstrictor activity, and circulating ghrelin. Therefore, we tested whether exogenous ghrelin may have benefits improve the balance between in patients obesity-related metabolic syndrome. Vasoactive actions of were assessed 8 syndrome matched controls by evaluating forearm blood flow responses (strain-gauge plethysmography) intra-arterial infusion BQ-123 (endothelin A...
Obesity is a chronic disease, whose incidence alarmingly growing. It associated with metabolic abnormalities and cardiovascular complications. These complications are clustered in the syndrome (MetS) leading to high morbidity mortality. predisposes diabetic nephropathy, hypertensive nephrosclerosis, focal segmental glomerular sclerosis represents an independent risk factor for development progression of kidney disease (CKD). Albuminuria major diseases (CVDs). Microalbuminuria has been...
Obesity represents one of the most complex public health challenges and has recently reached epidemic proportions. is also considered to be primarily responsible for rising prevalence metabolic syndrome, defined as coexistence in same individual several risk factors atherosclerosis, including dyslipidemia, hypertension hyperglycemia, well cancer. Additionally, presence three five (abdominal obesity, low high-density lipoprotein cholesterol, high triglycerides, fasting glucose blood pressure)...