A5101652402- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Cancer survivorship and care
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Cancer Treatment and Pharmacology
- Cancer Cells and Metastasis
- Childhood Cancer Survivors' Quality of Life
- Monoclonal and Polyclonal Antibodies Research
- Breast Lesions and Carcinomas
- Economic and Financial Impacts of Cancer
- Nutritional Studies and Diet
- Nanoplatforms for cancer theranostics
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Colorectal Cancer Screening and Detection
- Nanoparticle-Based Drug Delivery
- Genomic variations and chromosomal abnormalities
- Cancer-related cognitive impairment studies
- Multiple and Secondary Primary Cancers
- DNA Repair Mechanisms
- AI in cancer detection
- Lymphatic System and Diseases
National Cancer Center
2016-2025
Korea Research Institute of Standards and Science
2023
Korea University Medical Center
2009-2022
Gachon University Gil Medical Center
2022
Eulji General Hospital
2022
Sungkyunkwan University
2016-2021
Dongbang Culture University
2020
Seoul National University Bundang Hospital
2003-2020
Hanyang University
2019
Breast Cancer Research Foundation
2003-2019
Patients who have residual invasive carcinoma after the receipt of neoadjuvant chemotherapy for human epidermal growth factor receptor 2 (HER2)-negative breast cancer poor prognoses. The benefit adjuvant in these patients remains unclear.We randomly assigned 910 with HER2-negative (containing anthracycline, taxane, or both) to receive standard postsurgical treatment either capecitabine without (control). primary end point was disease-free survival. Secondary points included overall...
This study presents the 2016 nationwide cancer statistics in Korea, including incidence, survival, prevalence, and mortality.Cancer incidence data from 1999 to were obtained Korea National Cancer Incidence Database followed until December 31, 2017. Mortality 1983 Statistics Korea. The prevalence was defined as number of patients alive on January 1, 2017 among all diagnosed since 1999. Crude age-standardized rates (ASRs) for mortality, 5-year relative survivals also calculated.Overall,...
Purpose This study presents the 2015 nationwide cancer statistics in Korea, including incidence, survival, prevalence, and mortality. Materials Methods Cancer incidence data from 1999 to was obtained Korea National Incidence Database followed until December 31, 2016. Mortality 1983 were Statistics Korea. The prevalence defined as number of patients alive on January 1, 2016, among all diagnosed since 1999. Crude age-standardized rates (ASRs) for mortality 5-year relative survivals also...
This study reports the cancer statistics and temporal trends in Korea on a nationwide scale, including incidence, survival, prevalence, mortality 2017.The prevalence rates of were evaluated using data from National Cancer Incidence Database 1999 to 2017 with follow-up until December 31, 2018. Deaths assessed cause-of-death 1983 2017, obtained Statistics Korea. Crude age-standardized (ASRs) for mortality, 5-year relative survival calculated trend analysis was performed.In newly diagnosed...
Tumor-derived exosomes are gaining attention as important factors that facilitate communication between neighboring cells and manipulate cellular processes associated with cancer development or progression. The conventional techniques for the isolation detection of face several limitations, restricting their clinical applications. Hence, a highly efficient technique identification from biological samples may provide critical information about biomarkers improve our understanding unique role...
This study aimed to report the projected cancer incidence and mortality for year 2020 estimate Korea's current burden.Cancer data from 1999 2017 were obtained Korea National Cancer Incidence Database, 1993 2018 acquired Statistics Korea. by fitting a linear regression model observed age-specific rates against years then multiplying population. A Joinpoint was used determine in which trend changed significantly; we only of latest trend.In total, 243,263 new cases 80,546 deaths are expected...
We performed a retrospective review of (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) examination to determine the prevalence thyroid FDG-PET incidentaloma in patient group evaluated for metastasis cancer and healthy subjects who underwent voluntary screening. also risk malignancy focal its association with standard uptake values (SUVs) (maximum greater than 0.75 threshold). A total 1330 evaluation (n = 999) screening 331). Twenty-nine (2.2%) showed 21) or diffuse 8)...
Recent studies have revealed that disruption of vitamin A signaling observed in Alzheimer's disease (AD) leads to β-amyloid (Aβ) accumulation and memory deficits rodents. The aim the present study was evaluate therapeutic effect all- trans retinoic acid (ATRA), an active metabolite A, on neuropathology spatial learning amyloid precursor protein (APP) presenilin 1 (PS1) double-transgenic mice, a well established AD mouse model. Here we report robust decrease brain Aβ deposition tau...
Summary Background Between 10 and 30% of the fine needle aspiration biopsies (FNABs) thyroid nodules are diagnosed as ‘indeterminate’. A molecular diagnostic method is needed to reduce unnecessary surgery in this group. In Korea, most cancer classic papillary type BRAF V600E mutation highly prevalent. Aim To evaluate role pre‐operative detection FNAB specimens a mutation‐prevalent geographical area. Patients methods 137 (107 carcinomas (PTC); 3 follicular (FTC); 2 undifferentiated...
To determine whether an Internet-based tailored education program is effective for disease-free cancer survivors with cancer-related fatigue (CRF).We randomly assigned patients who had completed primary treatment within the past 24 months in any of four Korean hospitals and reported moderate to severe at least 1 week participate a 12-week, Internet-based, individually CRF or receive routine care. We based on guidelines National Comprehensive Cancer Network (NCCN) incorporated transtheoretic...
Breast cancer stem cells (BCSC) are resistant to conventional chemotherapy and radiotherapy, which may destroy tumor masses but not all BCSC that can mediate relapses. In the present study, we showed level of Wnt/β-catenin signaling in is relatively higher than bulk cells, contributing a therapeutic resistance. We designed highly potent small-molecule inhibitor, CWP232228, antagonizes binding β-catenin T-cell factor (TCF) nucleus. Notably, although CWP232228 inhibited growth both by...
Image enhancement: Core–shell [email protected]3O4 urchin-shaped nanoparticles can be synthesized by means of an anisotropic etching process and used as a pH-activatable T1 contrast agent for magnetic resonance imaging. The manganese ions released from the MnO phase in low-pH sites within tumor cells lead to enhanced image entire mass. Detailed facts importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made...
Diabetes is an established risk factor for developing cancer. A limited body of evidence also suggests that cancer can increase the new cases diabetes, but inconclusive.To evaluate whether development associated with increasing subsequent diabetes.This cohort study included a nationally representative sample Korean general population observed up to 10 years (January 1, 2003, December 31, 2013). total 524 089 men and women 20 70 age without diabetes no history at baseline were...
The balance in the immune system between surveillance against non-self-antigens and tolerance of self-antigens is known to be associated with prognosis breast cancer patients. However, immunologic signals tumor microenvironment according biological characteristics cells have not been clearly elucidated. CD4(+) T cells, CD8(+) forkhead box P3-positive (Foxp3) regulatory (Tregs) are main keys for tolerance, respectively. We evaluated correlations their impact on recurrence.CD8(+) Foxp3(+)...
This study aimed to report on cancer incidence and mortality for the year 2019 estimate Korea's current burden.Cancer data from 1999 2016 were obtained Korea National Cancer Incidence Database, 1993 2017 acquired Statistics Korea. projected by fitting a linear regression model observed age-specific rates against years, then multiplying population. The Joinpoint was used determine at which trend changed significantly; we only of latest trend.A total 221,347 new cases 82,344 deaths are...
Abstract Background Elucidating the molecular mechanisms by which tumors become resistant to Herceptin is critical for treatment of Her2-overexpressed metastatic breast cancer. Methods To further understand resistance at level, we used comparative proteome approaches analyze two human cancer cell lines; Her2-positive SK-BR-3 cells and its Herceptin-resistant (SK-BR-3 HR) cells. Results Heat-shock protein 27 (HSP27) expression was shown be upregulated in HR Suppression HSP27 specific siRNA...
Several in vitro studies have suggested the effects of adipokines and insulin resistance on breast cancer cell proliferation survival. However, little is known about clinical significance these findings. We examined associations between recurrence adiponectin, leptin, resistance, metabolic syndrome (MetS) a cohort 747 patients from 2001 to 2004. Adjusted hazard ratios showed an inverse trend across quartiles for serum adiponectin concentration estrogen receptor (ER)/progesterone (PR)...
While the inflammatory cytokine interleukin-18 (IL-18) is known to activate natural killer (NK) cells, its precise role in cancer controversial. In this study, we investigated of tumor-derived IL-18 on peripheral blood NK cells breast patients.In cell lines, was expressed and secreted triple-negative (TNBC) lines MDA-MB-231 HCC-70 but not MCF-7 cells. The immature non-cytotoxic CD56dimCD16dim/- fraction increased following co-culture with increase observed tumor transfected siRNA for or...
The quality of life for breast cancer survivors has become increasingly important because their high survival rate and prolonged expectancy. purpose this study was to examine the association physical activity following diagnosis health-related (HRQOL) in survivors. We conducted a cross-sectional A total 231 women aged 21–78 years who had been diagnosed with stages I III surgery at least 6 months prior were recruited from three hospitals between September 2012 April 2015 included study. asked...