A5077166961- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Polyomavirus and related diseases
- T-cell and B-cell Immunology
- Multiple Myeloma Research and Treatments
- Viral-associated cancers and disorders
- Mesenchymal stem cell research
- CAR-T cell therapy research
- Folate and B Vitamins Research
- Cytomegalovirus and herpesvirus research
- RNA modifications and cancer
- Renal Transplantation Outcomes and Treatments
- Neutropenia and Cancer Infections
- Hemoglobinopathies and Related Disorders
- Epigenetics and DNA Methylation
- Eosinophilic Disorders and Syndromes
- Porphyrin Metabolism and Disorders
- Erythrocyte Function and Pathophysiology
- Autoimmune and Inflammatory Disorders Research
- CNS Lymphoma Diagnosis and Treatment
Tohoku University Hospital
2016-2025
Tohoku University
2015-2025
International University of Health and Welfare
2022
Chiba University
2020
Center for Rheumatology
2016
National Cancer Center
2004-2008
Kyoto University
2008
Osaka International University
2008
Osaka University
2008
Japan Science and Technology Agency
2008
Naturally occurring Foxp3+CD4+ regulatory T cells (Tregs) are essential for maintaining immunological self-tolerance and immune homeostasis. Here, we show that a specific deficiency of cytotoxic lymphocyte antigen 4 (CTLA-4) in Tregs results spontaneous development systemic lymphoproliferation, fatal cell-mediated autoimmune disease, hyperproduction immunoglobulin E mice, it also produces potent tumor immunity. Treg-specific CTLA-4 impairs vivo vitro suppressive function Tregs-in particular,...
Naturally occurring CD4(+)CD25(+) regulatory T cells (Treg) suppress in vitro the proliferation of other a cell-contact-dependent manner. Dendritic (DCs) appear to be target Treg-mediated immune suppression. We show here that, coculture dye-labeled Treg and CD4(+)CD25(-) naïve presence cell receptor stimulation, cells, which are more mobile than vitro, out-compete latter aggregating around DCs. Deficiency or blockade leukocyte function-associated antigen-1 (LFA-1) (CD11a/CD18) abrogates...
Background. There is no standard management of reactivation hepatitis B virus (HBV) infection in HBV-resolved patients without surface antigen (HBsAg), but with antibodies against core and/or HBsAg (anti-HBs). Methods. We conducted a prospective observational study to evaluate the occurrence HBV by serial monthly monitoring DNA and establish preemptive therapy guided this B-cell non-Hodgkin lymphoma (B-NHL) treated rituximab plus corticosteroid-containing chemotherapy (R-steroid-chemo). The...
IntroductionWe previously reported an interim analysis of the DADI (dasatinib discontinuation) trial. The results showed that 48% patients with chronic myeloid leukemia in phase who maintained a deep molecular response (DMR) for ≥ 1 year could discontinue second- or subsequent-line dasatinib treatment safely at median follow-up 20 months. However, from longer periods would be much more useful clinical perspective.Patients and MethodsThe trial was prospective, multicenter conducted Japan....
Recent advances in unrelated cord blood transplantation have increased chances and options available allogeneic stem cell transplantation. The effect of HLA disparity on outcomes after was studied recently mainly pediatric populations. Results showed that matching combination with total nucleated dose positively affects survival. single-unit may be different adults because their is much lower compared to patients. We investigated the outcome separately 498 children aged 15 years or under...
Overexpression of programmed death-1 (PD-1) ligands contributes to an immunosuppressive microenvironment. Nivolumab is a PD-1-blocking antibody that inhibits the PD-1 pathway and showed good efficacy in several types malignancy. This phase II study examined safety nivolumab 17 Japanese patients with refractory/relapsed classical Hodgkin lymphoma previously treated brentuximab vedotin. Sixteen were included analyses analyses. The primary endpoint was centrally assessed objective response rate...
The hedgehog signaling pathway regulates multiple morphogenetic processes during embryogenesis. Aberrant activation of the signal transduction in adult tissues is associated with pathogenesis hematologic malignancies and solid tumors. We report findings from an open‐label, multicenter phase I trial selective, small‐molecule inhibitor glasdegib ( PF ‐04449913) Japanese patients select advanced malignancies. Glasdegib was administered as once‐daily oral doses (25, 50 100 mg) 28‐day cycles...
Abstract Belumosudil mesylate is a selective Rho‐associated coiled‐coil kinase 2 inhibitor with immunomodulatory and antifibrosis effects. This multicenter, open‐label, single‐arm study evaluated belumosudil 200 mg once daily as second or subsequent line of therapy (LOT) in 21 Japanese patients ≥12 years age steroid‐dependent/steroid‐resistant chronic graft‐versus‐host disease (cGVHD). The primary endpoint best overall response rate (ORR) at 24 weeks after enrollment the last patient was...
The impact of the direction HLA mismatch (MM) on outcome in unrelated cord blood (UCB) transplantation has not yet been clarified. We conducted a retrospective study using national registry data 2977 patients who underwent single UCB for leukemia or myelodysplastic syndrome. matching was assessed by serologic HLA-A, -B, and -DR loci. median age recipients at 41 years (range, 0-82 years), 2300 (77%) were ≥16 years. 2-year overall survival rate 0.46. presence MM only graft-versus-host...
Venetoclax (VEN) is used in patients with acute myeloid leukemia (AML) and primarily metabolized by CYP3A4, a major drug-metabolizing enzyme. Patients AML simultaneously administered VEN CYP3A4 inhibitors require more appropriate management of drug–drug interactions (DDIs). Here, we report two cases (54-year-old man 22-year-old woman) administrated inhibitors, such as posaconazole, cyclosporine, or danazol. In the first case, evaluated appropriateness timing for adjusting dosage subsequent...
This study aimed to evaluate the cost-effectiveness of isavuconazole compared with voriconazole as a first-line therapy for patients invasive aspergillosis prior differential pathogen diagnosis. Using state-transition model, cost-utility analysis was conducted in presumptive aspergillosis. The population consisted hematological malignancies undergoing hematopoietic stem cell transplantation (HSCT) or chemotherapy who developed fungal infections. incremental ratio (ICER) analyzed from...
Although allogeneic hematopoietic cell transplantation (HCT) is an alternative treatment for relapsed or refractory (R/R) acute promyelocytic leukemia (APL), little known regarding the utility of HCT R/R therapy-related APL (t-APL). We retrospectively analyzed data 144 patients with (t-APL, n = 20 and de novo APL, 124) who received a first between 2008 2020. found no significant differences in survival t-APL groups. The 3-year overall (OS) rates were 53.8% group 52.4% group. However, as...
Spontaneous regression or a long-term lack of obvious progression is often observed in patients with low-tumor-burden (LTB) follicular lymphoma (FL). However, conventional prognostic risk models are unable to precisely identify the who will not require any antilymphoma treatment for long term, especially at diagnosis. In this study, we identified genes whose expression levels were associated clinical outcome LTB FL and verified their value using immunohistochemistry. Because tumor...
Ultrasound (US)-mediated delivery is considered relatively safe and achieves tissue-specific targeting by simply adjusting the application site of physical energy. Moreover, combining US with micro- or nanobubbles (MBs NBs), which serve as contrast agents, enhances drugs, genes, nucleic acids also functioning a tool for US. The performance US-responsive MBs NBs, including their therapeutic outcomes, influenced bubble manufacturing methods. Furthermore, productivity scalability must be...