A5005279413- Titanium Alloys Microstructure and Properties
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Advanced machining processes and optimization
- Phytochemistry and Bioactive Compounds
- Renal Transplantation Outcomes and Treatments
- Dental materials and restorations
- Renal cell carcinoma treatment
- Advanced materials and composites
- Orthopaedic implants and arthroplasty
- Analytical Chemistry and Chromatography
- Advanced Machining and Optimization Techniques
- Transplantation: Methods and Outcomes
- Intermetallics and Advanced Alloy Properties
- Chronic Myeloid Leukemia Treatments
- Metal and Thin Film Mechanics
- Lysosomal Storage Disorders Research
- Chronic Lymphocytic Leukemia Research
- Hydrogen embrittlement and corrosion behaviors in metals
- Pharmacogenetics and Drug Metabolism
- Metabolomics and Mass Spectrometry Studies
- Additive Manufacturing Materials and Processes
- Welding Techniques and Residual Stresses
- Carbohydrate Chemistry and Synthesis
- Pneumocystis jirovecii pneumonia detection and treatment
Akita University Hospital
2024-2025
Tohoku University Hospital
2011-2024
Tohoku University
2009-2024
Kagoshima University
2024
Pharmac
2002-2023
Tohoku Medical and Pharmaceutical University
2003-2023
Tohoku Medical and Pharmaceutical University Hospital
2017-2020
Tottori University Hospital
2017
Komatsu (Japan)
2005-2011
The University of Tokyo
1994
Abstract Background Azole antifungals are the standard treatment for pulmonary mycosis, which may develop during long-term immunotherapy kidney transplant. Isavuconazole (ISCZ) is a cytochrome P450 (CYP) 3 A inhibitor that has risk of interacting with immunosuppressive drug tacrolimus (TAC). We report case simple aspergilloma renal dysfunction due to increased trough levels TAC after ISCZ coadministration. Case presentation male in his 60s was treated 3.0 mg/day orally prevent graft...
In this study, experimental Ti-Ag alloys (5, 10, and 20 mass% Ag) Ti-Cu (2, 5, 10 Cu) were made in an argon-arc melting furnace. The cast into magnesia molds using argon gas-pressure dental casting machine, the mechanical properties microstructures of castings investigated. As concentration silver or copper increased, tensile strength, yield hardness became higher than those CP Ti, elongation lower that Ti. Changes by alloying considered to be caused solid-solution strengthening a-phases...
Venetoclax (VEN) is used in patients with acute myeloid leukemia (AML) and primarily metabolized by CYP3A4, a major drug-metabolizing enzyme. Patients AML simultaneously administered VEN CYP3A4 inhibitors require more appropriate management of drug–drug interactions (DDIs). Here, we report two cases (54-year-old man 22-year-old woman) administrated inhibitors, such as posaconazole, cyclosporine, or danazol. In the first case, evaluated appropriateness timing for adjusting dosage subsequent...
Aiming at developing a dental titanium alloy with better mechanical properties and machinability than unalloyed titanium, series of Ti-Nb alloys Nb concentrations up to 30% was made. They were cast into magnesia-based molds using casting machine the grindability castings examined. The hardness 5% above significantly higher that titanium. yield strength tensile 10% those while elongation lower. A small addition niobium did not contribute improving Ti-30%Nb exhibited low grinding speed...
S-1, an oral anticancer drug, interacts with phenytoin (PHT) to increase PHT serum concentration. Although the dosage is usually adjusted, few studies have examined effects of switching from another antiepileptic drug. Here, we report details a case in which patient gastric cancer continued adjuvant chemotherapy after levetiracetam (LEV) prevent interactions S-1. A man his 60s advanced received S-1 120 mg/day (cycles two weeks administration followed by one week rest). He had experienced...
An analytical method using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry has been developed and validated for simultaneous measurement of four tyrosine kinase inhibitors used renal cell carcinoma their metabolites in human plasma. Despite similar structures, it is difficult to measure plasma levels these compounds simultaneously optimal MS parameters each compound because a quantitative range exceeding 50,000-fold required. To overcome this problem,...
Anodic polarization was performed in 0.9% NaCl and 1% lactic acid solutions to characterize the relationship between corrosion behavior microstructures of cast Ti-Au (5-40%) alloys. An abrupt increase current density occurred at approximately 0.6V vs. SCE for 30% 40% Au alloys solution. The after testing indicated that this breakdown may have been caused by preferential dissolution Ti3Au. However, potential higher than stainless steel or Co-Cr alloy, which meant resistance superior. In...
Six new secoiridoid glycosides, gentiascabraside A (1), 6β-hydroxyswertiajaposide (2), 1-O-β-d-glucopyranosyl-4-epiamplexine (3), and scabrans G3 (4), G4 (5), G5 (6), have been isolated from the rhizomes roots of Gentiana scabra together with a known compound, swertiajaposide (7). The structures compounds were determined by spectroscopic (NMR, MS) chemical means.
The purpose of this study was to improve the grindability titanium by alloying with zirconium. dental cast Ti-Zr alloys (10, 20, 30, 40 and 50 mass% Zr) evaluated using a carborundum wheel. up 30 Zr formed an α structure, α′ structure. Ti-40 alloy at 1000 m/min Ti-50 1250 exhibited significantly higher than titanium. More twice volume metal removed from per minute. improved could be attributed structure in addition decrease elongation. alloys, which phase are candidates for use as machinable...
In the present study, machinability of titanium, Ti-6Al-4V, Ti-6Al-7Nb, and free-cutting brass was evaluated using a milling machine. The metals were slotted with square end mills under four cutting conditions. force rotational speed spindle measured. forces for Ti-6Al-4V Ti-6Al-7Nb higher that lower than titanium. barely affected by cutting. cross sections chips more clearly serrated those which is an indication difficult-to-cut metals. There no marked difference in surface roughness cut...
Two new secoiridoid glycosides, swertiajaposide A (1) and B (2), a unsaturated alco-hol glycoside, 3-butenyl 6'-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside (3), lignan 7R,7'R,8S,8'S-(+)-neo-olivil-4-O-beta-D-glucopyranoside (4), were isolated together with six known compounds from the whole plants of Swertia japonica Makino. The structures elucidated on basis chemical spectroscopic evidence.
Anodic polarization tests were performed in 0.9% NaCl and 1% lactic acid solutions to characterize the relationship between corrosion behavior microstructures of cast Ti-Ag (5-40% Ag) alloys. The anodic curves for alloys up 17.5% Ag similar those pure titanium both solutions. On other hand, an abrupt increase current density was observed with more than 20% solution 27.5% solution. corroded alloy surfaces indicated deterioration precipitated intermetallic compounds along grain boundaries. had...
This study investigated the machinability of experimental Ti-Ag alloys (5, 10, 20, and 30 mass% Ag) as a new dental titanium alloy candidate for CAD/CAM use. The were slotted with vertical milling machine carbide square end mills under two cutting conditions. Machinability was evaluated through force using three-component transducer fixed on table machine. horizontal tended to decrease concentration silver increased. Values component perpendicular feed direction Ti-20%Ag Ti-30%Ag more than...
Niemann-Pick disease type C (NPC) is an autosomal recessive caused by a functional deficiency of cholesterol-transporting proteins in lysosomes, and exhibits various clinical symptoms. Since mitochondrial dysfunction NPC has recently been reported, cholesterol catabolism to steroid hormones may consequently be impaired. In this study, we developed comprehensive hormone analysis method using liquid chromatography/tandem mass spectrometry (LC-MS/MS) applied it analyze changes concentrations...
Abstract Background Anamorelin, a drug to treat cancer cachexia, binds ghrelin receptors and improves body weight appetite. In clinical trials in Japan, patients experienced 10.7% frequency of stimulant conduction system depression as severe side effect. Although rare, anamorelin sometimes causes fatal arrhythmias. Because with cachexia are often underweight, data on the safety obese lacking. We report case QT interval prolongation after administration an patient non-small cell lung cancer....
Three new triterpenoids, 2,3-seco-3-oxours-12-en-2-oic acid, 2,3-seco-3-oxoolean-12-en-2-oic and betulin 3-O-palmitate, have been isolated from the rhizomes roots of Gentiana lutea, together with five known ones. The structures compounds were determined by spectral chemical methods.