A5022145747- Drug Transport and Resistance Mechanisms
- Control and Dynamics of Mobile Robots
- Robotic Path Planning Algorithms
- Robotic Locomotion and Control
- Pharmacological Effects and Toxicity Studies
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Chemistry and Chromatography
- Earthquake Detection and Analysis
- Distributed Control Multi-Agent Systems
- Cardiac electrophysiology and arrhythmias
- Seismic Waves and Analysis
- Modular Robots and Swarm Intelligence
- Metabolism and Genetic Disorders
- Renal cell carcinoma treatment
- Ion channel regulation and function
- Mass Spectrometry Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Lysosomal Storage Disorders Research
- Inflammatory mediators and NSAID effects
- Renal Transplantation Outcomes and Treatments
- Cancer, Hypoxia, and Metabolism
- Pharmacogenetics and Drug Metabolism
- Nuclear physics research studies
- Adenosine and Purinergic Signaling
- Radioactive contamination and transfer
Yamagata University
2019-2025
Yamagata University Hospital
2019-2024
Aoyama Gakuin University
2012-2024
Osaka Metropolitan University
2024
Ishikiriseiki Hospital
2024
Tohoku University Hospital
2013-2022
Tohoku University
2011-2022
Kawasaki University of Medical Welfare
2022
Osaka Prefecture University
2018-2021
Institute for Materials Research, Tohoku University
2016-2020
Diabetic kidney disease is a major cause of renal failure that urgently necessitates breakthrough in management. Here we show using untargeted metabolomics levels phenyl sulfate, gut microbiota-derived metabolite, increase with the progression diabetes rats overexpressing human uremic toxin transporter SLCO4C1 kidney, and are decreased limited proteinuria. In experimental models diabetes, sulfate administration induces albuminuria podocyte damage. diabetic patient cohort, significantly...
This paper presents a novel feedback-control law for coordinating the motion of multiple holonomic mobile robots to capture/enclose target by making troop formations. coordination is cooperative behavior security against invaders in surveillance areas. Each robot this control has its own coordinate system and it senses target/invader, other obstacles, achieve without any collision. Although there no centralized controller each local feedback that relative-position feedback, all are...
There have been many reports on ultra-low-frequency (ULF) electromagnetic phenomena associated with earthquakes in a very wide frequency range. In this study, unusual behaviors of geomagnetic diurnal variations prior to the 2011 off Pacific coast Tohoku earthquake (Mw9.0) reported. Ratios variation range between target station Esashi (ESA) which is about 135 km from epicenter and remote reference Kakioka (KAK) 302 distant computed. The results 10-day running mean ratios showed clear anomaly...
Abstract To clarify and verify the ultralow frequency (ULF) seismomagnetic phenomena, we have performed statistical studies on geomagnetic data observed at Kakioka (KAK) station, Japan, during 2001–2010. We investigated energy of ULF signals around 0.01 Hz using wavelet transform analysis. minimize influences artificial noises global perturbations, used only nighttime (LT 2:30 A.M. to 4:00 A.M.) utilized observations from a remote Kanoya, as reference. Statistical results superposed epoch...
ABSTRACT Interest has recently been shown again in colistin because of the increased prevalence infections caused by multidrug-resistant Gram-negative bacteria. Although potential for nephrotoxicity is a major dose-limiting factor use, little known about mechanisms that underlie colistin-induced nephrotoxicity. In this study, we focused on an endocytosis receptor, megalin, expressed renal proximal tubules, with aim clarifying role megalin kidney accumulation and colistin. We examined binding...
Bile acids, the metabolites of cholesterol, are signaling molecules that play critical role in many physiological functions. They undergo enterohepatic circulation through various transporters expressed intestine and liver. Human organic anion-transporting polypeptides (OATP) 1B1 OATP1B3 contribute to hepatic uptake bile acids such as taurocholic acid. However, transport properties individual not well understood. Therefore, we selected HEK293 cells overexpressing OATP1B1 evaluate five major...
The relationship between the imide structures and morphology are discussed in order to develop heat resistant polyimides having excellent processability toughness. Addition-type oligomers consisting of asymmetric 2,3,3′,4′-biphenyltetracarboxylic dianhydride (a-BPDA) 3,4′-oxydianiline (3,4′-ODA) and/or 4,4′-oxydianiline (4,4′-ODA) with 4-phenylethynyl phthalic anhydride (PEPA) were synthesized characterized. derived from 3,4′-ODA; 4,4′-ODA (50:50) comonomer molecular weights 5240 g mol −1...
Hypertension in patients with chronic kidney disease (CKD) strongly associates cardiovascular events. Among CKD, reducing the accumulation of uremic toxins may protect against development hypertension and progression renal damage, but there are no established therapies to accomplish this. Here, overexpression human kidney-specific organic anion transporter SLCO4C1 rat reduced hypertension, cardiomegaly, inflammation setting failure. In addition, decreased plasma levels guanidino succinate,...
Mitochondrial dysfunction causes increased oxidative stress and depletion of ATP, which are involved in the etiology a variety renal diseases, such as CKD, AKI, steroid–resistant nephrotic syndrome. Antioxidant therapies being investigated, but clinical outcomes have yet to be determined. Recently, we reported that newly synthesized indole derivative, mitochonic acid 5 (MA-5), increases cellular ATP level survival fibroblasts from patients with mitochondrial disease. MA-5 modulates synthesis...
Aureobasidin A, an antifungal antibiotic inhibiting a wide range of pathogenic fungi, is lethal for growing cells susceptible fungi. We did cytological studies on the mechanism its fungicidal action against Saccharomyces cerevisiae. When cultures were treated with 5.0 micrograms aureobasidin A per ml, numbers viable started to decrease after 2 3 h incubation, and most had lost viability 5 6 h. cell death in began, amino acids released by could be detected, indicating disruption membrane. The...
Abstract We have studied the potential contribution of ABCG2 (breast cancer resistance protein) to nucleoside analogues. In cells transfected with DNA constructs resulting in overexpression human or mouse ABCG2, we found against cladribine, clofarabine, fludarabine, 6-mercaptopurine, and 6-mercaptopurine riboside both MDCKII HEK293 gemcitabine only cells. With Transwell studies MDCK transport experiments vesicles from Sf9 cells, show that is able not nucleotide CdAMP, like several other...
This study aimed to investigate the shear bond strength of an autopolymerizing resin a nylon denture base polymer (Lucitone FRS: LT) subjected different surface treatments, and results thereof compared with heat-polymerizing polycarbonate polymer. Specimens were divided into five groups according treatment method: polishing (#600), sandblasting, adhesive primer application (resin primer), sandblasting + application, tribochemical coating (Rocatec system). Following which, specimens test Si...
Mitochondrial dysfunction increases oxidative stress and depletes ATP in a variety of disorders. Several antioxidant therapies drugs affecting mitochondrial biogenesis are undergoing investigation, although not all them have demonstrated favorable effects the clinic. We recently reported therapeutic drug mitochonic acid MA-5 (Tohoku J. Exp. Med., 2015). increased ATP, rescued disease fibroblasts prolonged life span model "Mitomouse" (JASN, 2016). To investigate potential on various diseases,...
Background & AimsHypoxia-inducible factor 1α subunit (HIF1A) is a transcription that controls the cellular response to hypoxia and activated in hepatocytes of patients with nonalcoholic fatty liver disease (NAFLD). NAFLD increases risk for cholesterol gallstone by unclear mechanisms. We studied relationship between HIF1A formation associated steatosis.MethodsWe performed studies mice inducible disruption Hif1a via Cre adenoviral vector (inducible hepatocyte-selective knockout [iH-HIFKO]...
cGMP secretion from cells can be mediated by ATP‐binding cassette (ABC) transporters ABCC4, ABCC5, and ABCC11. Indirect evidence suggests that ABCC4 ABCC5 contribute to transport erythrocytes. We have re‐investigated the issue using erythrocytes wild‐type transporter knockout mice. Murine erythrocyte vesicles transported with an apparent K m was 100‐fold higher than their human counterparts, V max being similar. Whereas into efficiently inhibited ABCC4‐specific substrate prostaglandin E 1 ,...
This study sought to clarify the contributions of organic anion-transporting polypeptide (OATP) 1B1 and 1B3 liver uptake chenodeoxycholic acid (CDCA). We synthesized a fluorescent version CDCA, chenodeoxychilyl-(Nepsilon-NBD)-lysine (CDCA-NBD), characterize transporter-mediated uptake. CDCA-NBD is efficiently transported by OATP1B1 OATP1B3 with high affinities. The Michaelis-Menten constants for were 1.45 +/- 0.39 microM 0.54 0.09 microM, respectively. By confocal laser scanning microscopy,...