A5103127160- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Statistical Methods in Clinical Trials
- Advanced Causal Inference Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Lipids, and Metabolism
- Statistical Methods and Inference
- Statistical Methods and Bayesian Inference
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Lipoproteins and Cardiovascular Health
- Colorectal Cancer Treatments and Studies
- Renal cell carcinoma treatment
- HIV/AIDS Research and Interventions
- Hepatitis B Virus Studies
- Gastric Cancer Management and Outcomes
- Healthcare Policy and Management
- Coronary Interventions and Diagnostics
- Digital Mental Health Interventions
- Estrogen and related hormone effects
- Diabetes Treatment and Management
- Organ Transplantation Techniques and Outcomes
- HIV, Drug Use, Sexual Risk
- Diabetes Management and Research
The University of Tokyo
2016-2025
Kyushu University
2013-2024
Hanoi University
2023
University of Tokyo Hospital
2023
Japan Breast Cancer Research Group
2007-2021
Matsuyama University
2021
RMIT University
1996-2019
Cancer Research And Biostatistics
2019
Hiroshima University
2019
Kansai Medical University
2017-2018
We conducted a retrospective cohort study to investigate factors early and late phase recurrence of hepatocellular carcinoma (HCC).The population consisted 249 patients including 157 with cirrhosis who underwent hepatectomy for HCC. The endpoint was time-to-recurrence. Using Cox regression model, recurrences were investigated censoring recurrence-free at the 2-year time point in without 2 years.Actuarial probability overall 1, 3, 5 years 0.301, 0.623, 0.790, respectively, median follow-up...
Background & Aims: To elucidate the survival of patients with unresectable hepatocellular carcinoma (HCC) who underwent transcatheter arterial lipiodol chemoembolization (TACE) and to analyze factors affecting survivals. Methods: During last 8 years, a nationwide prospective cohort study was performed in 8510 HCC TACE using emulsion anticancer agents followed by gelatin sponge particles as an initial treatment. Exclusion criteria were extrahepatic metastases and/or any previous treatment...
In Brief Objectives: To evaluate the prognostic impact of anatomic versus nonanatomic resection on patients’ survival after a single hepatocellular carcinoma (HCC). Summary Background Data: Anatomic is reasonable treatment option for HCC; however, its clinical significance remains to be confirmed. Methods: Curative hepatic was performed HCC in 210 patients; patients were classified into (n = 156) and 54) groups. 84 assigned group, segmentectomy or subsegmentectomy performed. We evaluated...
The fourth version of Clinical Practice Guidelines for Hepatocellular Carcinoma was revised by the Japan Society Hepatology, according to methodology evidence-based medicine and partly Grading Recommendations Assessment, Development, Evaluation system, which published in October 2017 Japanese. New or recommendations were described, herein, with a special reference surveillance, diagnostic, treatment algorithms.
A randomized, controlled trial has begun to compare neoadjuvant chemotherapy using gemcitabine and S-1 with upfront surgery for patients planned resection of pancreatic cancer. Patients were enrolled after the diagnosis resectable or borderline by portal vein involvement cancer histological confirmation. They randomly assigned either surgery. Adjuvant was administered 6 months curative who fully recovered within 10 weeks in both arms. The primary endpoint is overall survival; secondary...
Advances in the diagnosis and surgical treatment of hepatocellular carcinoma (HCC) have improved prognosis for patients with HCC who undergo liver resection. The objective this study was to evaluate prognostic predictors underwent resection a Japanese nationwide data base.In study, authors analyzed 12,118 base between 1990 1999 compared them previous analysis 1982 1989. All were evaluated factors.During last decade, increases without hepatitis B virus surface antigen, had small tumors,...
In the 17th Nationwide Follow‐up Survey of Primary Liver Cancer in Japan, 18 213 individuals were newly registered as patients with primary liver cancer at 645 medical institutions over a period 2 years (from 1 January 2002 to 31 December 2003). Of these patients, 94.2% had hepatocellular carcinoma (HCC) and 4.1% intrahepatic cholangiocarcinoma (ICC). addition, 24 705 follow‐up survey. Epidemiological clinicopathological factors, diagnosis treatment investigated cumulative survival rates...
In this article, we show the general relation between standardization methods and marginal structural models. Standardization has been recognized as a method to control confounding estimate causal parameters of interest. Because requires stratification by confounders, sparse-data problem will occur when stratified many confounders one then might have an unstable estimator. A new class models called recently proposed. models, are consistently estimated inverse-probability-of-treatment...
The 3rd version of Clinical Practice Guidelines for Hepatocellular Carcinoma was revised by the Japan Society Hepatology, according to methodology evidence-based medicine, which published in October 2013 Japanese. Here, we briefly describe new or changed recommendations with a special reference two algorithms surveillance, diagnosis, and treatment.
In Brief Objective: The aims of this study were to present evidence develop and validate the Japanese Tumor-Node-Metastasis (TNM) staging system for primary liver cancer compare its discriminatory ability predictive power with those Vauthey's simplified staging, which was adopted as TNM American Joint Committee on Cancer (AJCC)/International Union Against (UICC). Summary Background Data: Among many systems hepatocellular carcinoma, AJCC/UICC developed based a survival analysis surgical...
The Clinical Practice Guidelines for Hepatocellular Carcinoma (HCC), the first evidence-based guidelines treatment of HCC in Japan, were compiled by an expert panel supported Japanese Ministry Health, Labour, and Welfare. This set covers six research fields: prevention, diagnosis surveillance, surgery, chemotherapy, transarterial chemoembolization, percutaneous local ablation therapy. A systematic review English medical literature on was performed, a total 7192 publications extracted, mainly...
<b><i>Background/Aim:</i></b> Recently, albumin-bilirubin (ALBI) scoring/grading, consisting of only albumin and total bilirubin, has been proposed. We examined the efficacy this grading system for determining hepatic function in patients with hepatocellular carcinoma (HCC). <b><i>Methods/Materials:</i></b> The prognoses 46,681 HCC based on results obtained from a nationwide survey conducted Japan 2001 to 2007 were evaluated using (1)...
189 Background: Despite improvements of postoperative adjuvant therapy for resected pancreatic ductal adenocarcinoma (PDAC), its prognosis remains poor. A randomized controlled trial has begun to compare neoadjuvant chemotherapy using gemcitabine and S1 (NAC-GS) with upfront surgery (Up-S) patients PDAC planned resection. Methods: Patients were enrolled after the diagnosis resectable histological confirmation. They randomly assigned as either NAC-GS or Up-S. In NAC-GS, was provided at a dose...
Because of the rarity hepatic vein tumor thrombus (HVTT) compared with portal (PVTT) in patients hepatocellular carcinoma, little is known about this disease entity. The aim study was to evaluate prognosis each treatment modality for HVTT through an analysis data collected a Japanese nationwide survey. We analyzed 1,021 Child-Pugh A carcinoma without inferior vena cava invasion registered between 2000 and 2007. Of these patients, 540 who underwent liver resection (LR) 481 received other...
The fifth version of the Clinical Practice Guidelines for Hepatocellular Carcinoma was revised by Japan Society Hepatology, according to methodology evidence-based medicine and partly Grading Recommendations Assessment, Development Evaluation system, which published in October 2021 Japanese. In addition surveillance-diagnostic treatment algorithms, a new algorithm systemic therapy has been created, as multiple drugs hepatocellular carcinoma can be currently selected. Here, or algorithms...
It remains unclear which surgery or radiofrequency ablation (RFA) is the more effective treatment for small hepatocellular carcinoma (HCC). We aimed to compare survival between patients undergoing (surgery group) and RFA (RFA group).We conducted a randomized controlled trial involving 49 institutions in Japan. Patients with Child-Pugh scores ≤7, largest HCC diameter ≤3 cm, nodules were considered eligible. The co-primary endpoints recurrence-free (RFS) overall (OS). current study reports...
This study aims to conduct a bibliometric analysis of research intersecting the Sustainable Development Goals (SDGs) and Maqasid Shariah Tafsir, with focus on using VOSviewer software visualize patterns trends. The spans last decade, exploring publication trends over time, influential journals, prolific authors, most productive countries institutions in this field. results show significant growth integrating principles, focusing preservation religion, life, intellect, lineage, wealth, 17...
Preoperative portal vein embolization (PVE) was performed in 84 patients before extensive liver resection for various diseases. By the criteria of volumetric determination, some were candidates PVE, whereas others not, even though same surgical procedure, such as extended right lobectomy (ERL), scheduled. PVE using gelatin sponge powder induced hypertrophy nonembolized lobe (0%-171%; median, 30%) and proportional atrophy embolized 2 weeks without eliciting any major inflammatory or necrotic...
Portal venous tumour extension and intrahepatic metastasis result in a poor prognosis following hepatectomy for hepatocellular carcinoma (HCC). Anatomical resection is, theory, preferable eradicating these types of invasion. Des-gamma-carboxy prothrombin (DCP) has been reported to be associated with adverse pathological variables. This study investigated the significance anatomical DCP as predictive factors postoperative recurrence HCC.A retrospective cohort was carried out 138 consecutive...