A5016215778- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Lung Cancer Treatments and Mutations
- Statistical Methods in Clinical Trials
- Gastric Cancer Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Acute Ischemic Stroke Management
- Health Systems, Economic Evaluations, Quality of Life
- Radiomics and Machine Learning in Medical Imaging
- Cancer Treatment and Pharmacology
- Organ Transplantation Techniques and Outcomes
- Heart Rate Variability and Autonomic Control
- Liver Disease and Transplantation
- Antiplatelet Therapy and Cardiovascular Diseases
- Lung Cancer Research Studies
- Colorectal Cancer Surgical Treatments
- Eating Disorders and Behaviors
- Sodium Intake and Health
- Colorectal Cancer Screening and Detection
- Endometriosis Research and Treatment
- Optimal Experimental Design Methods
- Cardiac Imaging and Diagnostics
- Glaucoma and retinal disorders
Kyoto Prefectural University of Medicine
2016-2025
University Hospital Kyoto Prefectural University of Medicine
2021-2025
Japan Cancer Society
2024
Nagoya University Hospital
2006-2021
The University of Tokyo
2019
Translational Research Informatics Center (Japan)
2005-2018
Foundation for Biomedical Research and Innovation
2007-2018
Biostatistical Consulting (United States)
2017
Outcomes Research Consortium
2017
Japanese Society of Hypertension
2016
In cancer patients, the balance between neutrophil (N) and lymphocyte (L) cell counts fluctuates with advancing disease. The objective of our study was to determine prognostic implications N/L ratio in peripheral blood gastric patients.Study participants were identified from a prospective cohort patients advanced Japan (n = 1,220).The median baseline 2.58 (range, 0.63-12.7). Univariate analysis revealed that an > pr =2.5 644) had significantly poorer prognosis than those <2.5 576; log rank...
Corneal endothelial cell (CEC) disorders, such as Fuchs's corneal dystrophy, induce abnormal hydration and result in haziness vision loss known bullous keratopathy. We investigated whether injection of cultured human CECs supplemented with a rho-associated protein kinase (ROCK) inhibitor into the anterior chamber could increase CEC density.We performed an uncontrolled, single-group study involving 11 persons who had received diagnosis keratopathy no detectable CECs. Human were from donor...
Background: Thyroid storm (TS) is life threatening. Its incidence poorly defined, few series are available, and population-based diagnostic criteria have not been established. We surveyed TS in Japan, defined its characteristics, formulated criteria, FINAL-CRITERIA1 FINAL-CRITERIA2, for two grades of TS, TS1, TS2 respectively. Methods: first developed based on 99 patients the literature 7 our (LIT-CRITERIA1 TS1 LIT-CRITERIA2 TS2). Thyrotoxicosis was a prerequisite as well combinations...
Objective To investigate the success rate of cold snare polypectomy (CSP) for complete resection 4–9 mm colorectal adenomatous polyps compared with that hot (HSP). Design A prospective, multicentre, randomised controlled, parallel, non-inferiority trial conducted in 12 Japanese endoscopy units. Endoscopically diagnosed sessile polyps, size, were randomly assigned to CSP or HSP group. After removal polyp using allocated technique, biopsy specimens from margin after obtained. The primary...
Thyroid storm is an endocrine emergency which characterized by multiple organ failure due to severe thyrotoxicosis, often associated with triggering illnesses. Early suspicion, prompt diagnosis and intensive treatment will improve survival in thyroid patients. Because of its rarity high mortality, prospective intervention studies for the are difficult carry out. We, Japan Association Endocrine Society taskforce committee, previously developed new diagnostic criteria conducted nationwide...
OBJECTIVE: It has been demonstrated that ghrelin plays a major role in the regulation of GH secretion and food intake. These actions make strong candidate for treatment deficiency, anorexia cachexia. However, only preliminary studies have performed to assess administration humans. In this study, we conducted double-blind, randomized, placebo-controlled trial investigate pharmacokinetics, safety, endocrine appetite effects young healthy volunteers. DESIGN: Eighteen male volunteers were...
Purpose To explore whether population-related pharmacogenomics contribute to differences in patient outcomes between clinical trials performed Japan and the United States, given similar study designs, eligibility criteria, staging, treatment regimens. Methods We prospectively designed conducted three phase III (Four-Arm Cooperative Study, LC00-03, S0003) advanced-stage, non–small-cell lung cancer, each with a common arm of paclitaxel plus carboplatin. Genomic DNA was collected from patients...
ABO-incompatible (ABO-I) living donor liver transplantation (LDLT) has been performed in Japan to overcome the organ shortage. Reported herein are results of this approach through March 2006 National Registry Study Group for transplantation. The questionnaires consisted patient characteristics, operative data, and strategies preventing antibody-mediated rejection (AMR). Data 291 patients (follow-up period, 8 months-15 years; mean, 35 months) from 28 institutions were collected. Age was...
Des-gamma-carboxy prothrombin (DCP) levels reportedly correlate with histological features of hepatocellular carcinoma (HCC). We examined serum DCP as a predictor HCC recurrence in 144 patients who underwent living donor liver transplantation. Receiver operating characteristics (ROC) analysis revealed superiority and AFP over preoperative tumor size or number for predicting recurrence. Multivariate >5 cm, > =11 nodules, >400 mAU/mL significant independent risk factors Incidence microvascular...
We evaluated the effects of rituximab prophylaxis on outcomes ABO-blood-type-incompatible living donor liver transplantation (ABO-I LDLT) in 381 adult patients Japanese registry ABO-I LDLT. Patients underwent dual or triple immunosuppression with without B cell desensitization therapies such as plasmapheresis, splenectomy, local infusion, intravenous immunoglobulin and rituximab. Era before 2005, intensive care unit-bound status, high Model for End-Stage Liver Disease score absence were...
Few studies have evaluated out-of-office blood pressure (BP) measurements as predictors of coronary artery disease (CAD) events.The aim this study was to determine morning home (HBP) a predictor CAD events.Using data from the HONEST (Home measurement with Olmesartan Naive patients Establish Standard Target pressure) study, we investigated relationship between HBP and incidence stroke events.In 21,591 treated hypertensive (mean age 64.9 years; mean follow-up 2.02 years), 127 events (2.92 per...
This study aimed to investigate the relationship between on-treatment morning home blood pressure (HBP) and incidence of cardiovascular events using data from Home Blood Pressure Measurement With Olmesartan Naive Patients Establish Standard Target (HONEST) study, a prospective observational 21 591 outpatients with essential hypertension (mean age, 64.9 years; women, 50.6%) enrolled 2009 2010 at clinics hospitals in Japan. They received olmesartan-based treatment throughout. The primary end...
The International Union Against Cancer highlighted tumor budding as a tumor-related prognostic factor. assessment criteria for were recently defined by the 2016 Tumor Budding Consensus Conference (ITBCC2016). This study aimed to clarify and predictive values of in randomized controlled trial evaluating superiority adjuvant chemotherapy with oral tegafur-uracil over surgery alone stage II colon cancer (SACURA trial; ClinicalTrials.gov identifier: NCT00392899).
To report the safety and efficacy of a novel cell injection therapy using cultured human corneal endothelial cells (hCECs) for failure conditions via long-term 5-year postoperative clinical data from first-in-humans trial group.Prospective observational study.This study involved 11 eyes patients with pseudophakic who underwent hCEC between December 2013 2014.All follow-up examinations at 1 week, 4 weeks, 12 24 weeks year, 2 years, 3 5 years after surgery. Specific parameters (i.e., density...
Abstract Modern society characterized by a 24/7 lifestyle leads to misalignment between environmental cycles and endogenous circadian rhythms. Persisting deleterious effects on health healthspan. However, the underlying mechanism remains not fully understood. Here, we subjected adult, wild-type mice distinct chronic jet-lag paradigms, which showed that long-term induced significant early mortality. Non-biased RNA sequencing analysis using liver kidney marked activation of gene regulatory...
// Tomonori Yano 1 , Hiroi Kasai 2 Takahiro Horimatsu 3 Kenichi Yoshimura 4 Satoshi Teramukai 5 Morita Harue Tada Yoshinobu Yamamoto 6 Hiromi Kataoka 7 Naomi Kakushima 8 Ryu Ishihara 9 Hajime Isomoto 10 Manabu Muto Department of Gastroenterology, Endoscopy division, National Cancer Center Hospital East, Kashiwa, Japan Institute for Advancement Clinical and Translational Science, Kyoto University Hospital, Kyoto, Therapeutic Oncology, Graduate School Medicine, University, Innovative Research...
In oncology, next generation sequencing and comprehensive genomic profiling have enabled the detailed classification of tumors using molecular biology. However, it is unrealistic to conduct phase I-III trials according each sub-population based on patient subtypes. Common protocols that assess combination several markers their targeted therapies by means multiple sub-studies are required. These called "master protocols," drawing attention as a next-generation clinical trial design. Recently,...
Abstract Background The characterisation of desmoplastic reaction (DR) has emerged as a new, independent prognostic determinant in colorectal cancer. Herein, we report the validation its value randomised controlled study (SACURA trial). Methods included 991 stage II colon cancer patients. DR was classified by central review Mature, Intermediate or Immature based on presence hyalinised collagen bundles and myxoid stroma at front. All clinical pathological data, including characterisations,...