A5033920937- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- Photodynamic Therapy Research Studies
- Colorectal Cancer Screening and Detection
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Tracheal and airway disorders
- Colorectal and Anal Carcinomas
- Nanoplatforms for cancer theranostics
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
National Cancer Center Hospital East
2016-2025
Juntendo University
2017-2024
The Japanese Society of Gastroenterological Surgery
2020-2024
Akashi Medical Center
2022-2024
Iwate Medical University
2024
Onomichi General Hospital
2024
Hiroshima University
2024
Jichi Medical University
2023
Yokohama City University
2021
University of Shizuoka
2021
Most of the esophageal squamous cell carcinomas (ESCCs) and cancers head neck (H&N) region are diagnosed at later stages. To achieve better survival, early detection is necessary. We compared real-time diagnostic yield superficial cancer in these regions between conventional white light imaging (WLI) narrow band (NBI) high-risk patients.In a multicenter, prospective, randomized controlled trial, 320 patients with ESCC were randomly assigned to primary WLI followed by NBI (n = 162) or 158)...
The Japan Gastroenterological Endoscopy Society has developed endoscopic submucosal dissection/endoscopic mucosal resection guidelines. These guidelines present recommendations in response to 18 clinical questions concerning the preoperative diagnosis, indications, methods, curability assessment, and surveillance of patients undergoing for esophageal cancers based on a systematic review scientific literature.
Some patients develop multiple squamous cell carcinomas (SCCs) in the upper aerodigestive tract, attributed to field cancerization; alcohol consumption has been associated with this process. We examined association between areas of dysplastic epithelium development SCC esophagus or head and neck cancer, as well smoking.We 331 early stage esophageal using Lugol chromoendoscopy evaluate esophagus. Patients then were assigned 3 groups, based on number Lugol-voiding lesions: A, no lesion; B, 1-9...
Background & AimsEsophagectomy is the standard treatment for stage I esophageal squamous cell carcinoma (ESCC). We conducted a single-arm prospective study to confirm efficacy and safety of selective chemoradiotherapy (CRT) based on findings from endoscopic resection (ER).MethodsWe performed patients with T1b (SM1–2) N0M0 thoracic ESCC December 2006 through July 2012; 176 underwent ER. Based ER, received following: no additional pT1a tumors negative margin lymphovascular invasion (group A);...
We earlier reported that mucosal defect involving over three-fourths of the circumference esophagus after endoscopic resection (EMR) is a risk factor for development stricture. Although balloon dilation (EBD) useful procedure to relieve stricture, there no standard strategy preventing The aim this study was evaluate efficacy and safety preventive EBD.From 1993 2008, 41 consecutive patients with extensive esophageal EMR or submucosal dissection (ESD) were investigated. Preventive EBD carried...
Objectives A Japanese multicenter prospective cohort study examining endoscopic resection ( ER ) for early gastric cancer EGC has been conducted using a Web registry developed to determine the short‐term and long‐term outcomes based on absolute expanded indications. We hereby present of this study. Methods All consecutive patients with or suspected undergoing at 41 participating institutions between July 2010 June 2012 were enrolled prospectively registered into registry. The baseline...
Endoscopic image diagnosis assisted by machine learning is useful for reducing misdetection and interobserver variability. Although many results have been reported, few effective methods are available to automatically detect early gastric cancer. Early cancer poor morphological features, which implies that automatic detection can be extremely difficult construct. In this study, we proposed a convolutional neural network-based scheme assist the of in endoscopic images. We performed transfer...
Early detection of gastric cancer has been the topic major efforts in high prevalence areas. Whether advanced imaging methods, such as second-generation narrow band (2G-NBI) can improve early detection, is unknown.This open-label, randomised, controlled tandem trial was conducted 13 hospitals. Patients at increased risk for were randomly assigned to primary white light (WLI) followed by secondary 2G-NBI (WLI group: n=2258) and WLI (2G-NBI n=2265) performed same examiner. Suspected (EGC)...
// Tomonori Yano 1 , Hiroi Kasai 2 Takahiro Horimatsu 3 Kenichi Yoshimura 4 Satoshi Teramukai 5 Morita Harue Tada Yoshinobu Yamamoto 6 Hiromi Kataoka 7 Naomi Kakushima 8 Ryu Ishihara 9 Hajime Isomoto 10 Manabu Muto Department of Gastroenterology, Endoscopy division, National Cancer Center Hospital East, Kashiwa, Japan Institute for Advancement Clinical and Translational Science, Kyoto University Hospital, Kyoto, Therapeutic Oncology, Graduate School Medicine, University, Innovative Research...
Local failure after definitive chemoradiotherapy (CRT) in patients with esophageal cancer remains one of the major problems finding a cure. Endoscopic mucosal resection (EMR) is treatment option when lesions are superficial. However, there no relevant long-term survival data. The aim this study was to clarify salvage EMR.Between January 1998 and March 2004, 289 squamous cell carcinoma were treated CRT at National Cancer Center Hospital East, Japan. Of these patients, 21 local without...
To clarify the effectiveness of second-look endoscopy (SLE) at preventing bleeding after gastric endoscopic submucosal dissection (ESD).A multicentre prospective randomised controlled non-inferiority trial was conducted five referral institutions across Japan. Patients with a solitary neoplasm were enrolled. Exclusion criteria previous oesophagogastric surgery or radiation therapy; perforation and administration antithrombotics, steroids non-steroidal anti-inflammatory drugs. assigned to SLE...
Local failure at the primary site is a major problem after chemoradiotherapy (CRT) in patients with esophageal squamous cell carcinoma (ESCC). Salvage surgery only treatment option curative intent, but it associated high morbidity and mortality. The aim of this study was to evaluate efficacy safety salvage photodynamic therapy (PDT) CRT. Patients histologically proven local limited submucosal layer, without any metastasis definitive CRT (≥50 Gy) for ESCC were enrolled study. PDT began...
A prospective comparative study about the incidence of postoperative C5 palsy and multivariate analysis risk factors palsy.To clarify occurrence after laminoplasty (LP) by comparing 2 surgical procedures open-door double-door LP prospectively.The has been reported to average 4.6%, there no difference among procedures. However, were only indirect retrospective studies.A total 146 patients who underwent procedure between 2006 2007 studied prospectively. In 2006, assigned undergo LP, in 2007,...
Abstract Background Photodynamic therapy (PDT) is a less invasive and effective salvage treatment for local failure after chemoradiotherapy (CRT) esophageal cancer, however it causes high rate of skin phototoxicity requires long sun shade period. Talaporfin sodium rapidly cleared photosensitizer that expected to have phototoxicity. This study was undertaken clarify the optimum laser fluence PDT using talaporfin diode patients with CRT or radiotherapy (RT) cancer. Methods phase I, dose...
<b>Background and study aims:</b> The novel method of image-enhanced endoscopy (IEE) named blue laser imaging (BLI) can enhance the contrast surface vessels using lasers for light illumination. BLI has two IEE modes: high mode (BLI-contrast) use with magnification, bright (BLI-bright), which achieves a brighter image than BLI-contrast yet maintains enhanced visualization vascular that is expected detection tumors from far field view. aim this to clarify effect BLI-bright view compared...