A5015844777- Gastric Cancer Management and Outcomes
- Neuropeptides and Animal Physiology
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Pancreatic function and diabetes
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer, Lipids, and Metabolism
- Neurological Disorders and Treatments
- Esophageal Cancer Research and Treatment
- Nutrition, Genetics, and Disease
- Metabolomics and Mass Spectrometry Studies
- Diverticular Disease and Complications
- Pharmacological Effects of Natural Compounds
- Cancer Treatment and Pharmacology
- Colorectal Cancer Screening and Detection
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Diet, Metabolism, and Disease
Tokyo Metropolitan Tama-Hokubu Medical Center
2020-2024
Kobe University
1990-2022
Ebara Hospital
2015-2017
Hyogo Prefectural Cancer Center
2011-2017
Kobe University Hospital
2013
National Cancer Center Hospital East
2013
Kawasaki Hospital
2007
Shiga Medical Center for Adults
1996-2004
Akashi Medical Center
1996
Chemotherapy Foundation
1991
To improve the prognosis of patients with pancreatic cancer, more accurate serum diagnostic methods are required. We used metabolomics as a method for cancer.Sera from healthy volunteers, and chronic pancreatitis were collected at multiple institutions. The cancer volunteers randomly allocated to training or validation set. All cases included in In each study, subjects' metabolites analyzed by gas chromatography mass spectrometry (GC/MS) data processing system using an in-house library....
We conducted a multicenter, retrospective study to determine the anatomical distribution and prognostic factors of gastrointestinal (GI) follicular lymphoma (FL). This included 125 patients with stage I II(1) GI-FL. Of patients, small intestine was examined in 70 double-balloon endoscopy and/or capsule endoscopy. The most frequently involved GI-FL site duodenal second portion (DSP) (81%), followed by jejunum (40%); 85% involvement DSP also had jejunal or ileal lesions. absence abdominal...
ObjectiveOwing to the risks of serious and sustained toxicity, anticancer drugs such as cisplatin irinotecan cannot be readily administered patients with gastric cancer severe peritoneal metastasis. Therefore, a standard chemotherapy regimen has yet established for these types patients. This randomized study investigated utility sequential methotrexate 5-fluorouracil therapy vs. continuous infusion
Abstract Background Photodynamic therapy (PDT) is a less invasive and effective salvage treatment for local failure after chemoradiotherapy (CRT) esophageal cancer, however it causes high rate of skin phototoxicity requires long sun shade period. Talaporfin sodium rapidly cleared photosensitizer that expected to have phototoxicity. This study was undertaken clarify the optimum laser fluence PDT using talaporfin diode patients with CRT or radiotherapy (RT) cancer. Methods phase I, dose...
Background and study aim Magnifying narrow-band imaging (M-NBI) is useful for the accurate diagnosis of early gastric cancer (EGC). However, acquiring skill at M-NBI takes substantial effort. An Internet-based e-learning system to teach endoscopic EGC using has been developed. This evaluated its effectiveness. Participants methods was designed as a multicenter randomized controlled trial. We recruited endoscopists participants from all over Japan. After completing Test 1, which consisted...
Background . Delayed perforation is a rare but severe complication of endoscopic submucosal dissection (ESD) for early gastric neoplasm (EGN). The aim this study was to clarify clinical factors related delayed after ESD. Methods A total 1158 consecutive patients with 1199 EGNs underwent ESD at our hospital between January 2000 and December 2015. Univariate analysis used identify clinicopathological perforation. Moreover, duration cautery needed hemostasis measured by comparison perforated...
Kounis syndrome is defined as the concurrence of acute coronary syndromes in setting allergic or anaphylactic reactions. It primarily affects men aged 40–70 years and often associated with chest pain. This unrecognized undiagnosed clinical practice due to a low level awareness. Herein, we present case type I young woman without A 28-year-old Japanese history atopic dermatitis received glycyrrhizin, glutathione, neurotropin preparation (a inflamed skin extract from rabbits inoculated vaccinia...
We studied cellular processes activated by prostaglandins (PG) that are involved in the protection of gastric chief cell injury estimated terms dye exclusion test, release lactate dehydrogenase (LDH), or 51Cr from prelabeled cells. Pretreatment cells with 3 x 10(-6) M PGE2 PGE1 at 37 degrees C and pH 7.4 for 15 min maximally reduced not only ethanol- but also taurocholic acid-caused LDH PGs equipotently stimulated increases accumulation diacylglycerol cyclic AMP without elevating...
Dengue fever (DF) can be complicated by hemophagocytic lymphohistiocytosis (HLH). Steroid administration is markedly effective for this hematologic complication, and other viral infections. We present a rare case of DF-associated HLH that improved with steroid-sparing supportive care. A 47-year-old Japanese male diabetes mellitus no history DF traveled to the Philippines 10 days before his hospitalization. Three emergency admission, he experienced joint pain was referred our hospital...
COVID-19 can lead to severe pneumonia, requiring mechanical ventilation. While increased sputum secretion could cause airway obstruction during ventilation, there are few reported cases in the literature. We report a case of 65-year-old man with diabetes and pneumonia ventilation treated hydroxychloroquine, azithromycin, nafamostat, prone positioning. Initially, consisted heat moisture exchanger, endotracheal tube aspiration, subglottic drainage using closed suction system. However,...
This study investigated the frequency of adverse reactions to COVID-19 vaccines in Japan and impact first-dose on second-dose reactions. Individuals who received an mRNA vaccine at our center March or April 2021 were included. Data collected using questionnaires. The main factors age (<40, 40−59, >60 years), sex, underlying disease, reaction. primary outcomes incidence local systemic (ARs) attributable vaccine. Logistic regression was used calculate odds ratios (ORs) 95% confidence intervals...
Introduction: Favorable long-term outcomes of endoscopic submucosal dissection (ESD) for early remnant gastric cancer (ERGC) have been reported in single-center studies from advanced institutions. However, no examined the using a multicenter database. This study aimed to investigate aforementioned approach large Methods: retrospective cohort included 242 cases with 256 lesions that underwent ESD ERGC between April 2009 and March 2019 across 12 centers. We investigated these patients...
The effects of cholecystokinin (CCK) and other pancreatic secretagogues on phosphatidylcholine (PC) synthesis were studied in isolated rat acini. When acini incubated with [3H]choline the presence 1 nM CCK-octapeptide (CCK8) for 60 min, incorporations into both water-soluble choline metabolites PC reduced by CCK8 to 74 41% control, respectively. Pulse-chase study revealed that disappearance phosphocholine PC. Other Ca(2+)-mobilizing such as carbamylcholine, bombesin, Ca2+ ionophore A23187...