A5006603221- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Screening and Detection
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Head and Neck Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Respiratory Support and Mechanisms
Hokkaido University
2023-2024
Otsuka (Japan)
2023
National Cancer Center Hospital East
2011-2021
Nagaoka University of Technology
2018
Murata (Japan)
2013-2018
Juntendo University
2017
Jikei University School of Medicine
2003-2017
Japan Chemical Industry Association
2017
Niigata Prefectural Central Hospital
2016
National Cancer Research Institute
2016
Surgical or pharmacologic interruption of muscarinic innervation to the stomach suppresses gastric tumor growth in mice and humans.
PURPOSE: To investigate the efficacy and feasibility of concurrent chemoradiotherapy for locally advanced carcinoma esophagus. PATIENTS AND METHODS: Fifty-four patients with clinically T4 and/or M1 lymph node (LYM) squamous cell esophagus were enrolled. Patients received protracted infusion fluorouracil 400 mg/m 2 /24 hours on days 1 to 5 8 12, 2-hour cisplatin 40 8, radiation therapy at a dose 30 Gy in 15 fractions over 3 weeks. Filgrastim was prophylactically administered 35 patients. This...
Some patients develop multiple squamous cell carcinomas (SCCs) in the upper aerodigestive tract, attributed to field cancerization; alcohol consumption has been associated with this process. We examined association between areas of dysplastic epithelium development SCC esophagus or head and neck cancer, as well smoking.We 331 early stage esophageal using Lugol chromoendoscopy evaluate esophagus. Patients then were assigned 3 groups, based on number Lugol-voiding lesions: A, no lesion; B, 1-9...
Abstract Background Capillary patterns (CP) observed by magnifying Narrow Band Imaging (NBI) are useful for differentiating non-adenomatous from adenomatous colorectal polyps. However, there few studies concerning the effectiveness of NBI determining depth invasion in early neoplasms. We aimed to determine whether CP type IIIA/IIIB identified is effective estimating Methods A series 127 consecutive patients with 130 lesions were evaluated October 2005 2007 at National Cancer Center Hospital...
Summary Background The presence of abnormal microcapillaries detected by narrow band imaging (NBI) with magnifying colonoscopy has been reported to be a marker colorectal neoplasia. Aim To investigate prospectively if NBI magnification could help predict the histology early Methods A series 104 consecutive patients 139 lesions were studied. All conventional and subsequently evaluated magnification. During magnification, microvascular architecture observed on surface lesions, capillary...
<b>Background and study aims:</b> Patients with submucosal invasive colorectal cancer (SM-CRC) treated endoscopic resection who are at low risk of lymph node metastasis local recurrence may be followed up observation alone, while additional surgery is recommended for those high features. However, the long-term outcomes that these strategies offer still unclear. The objective our was to retrospectively evaluate patients SM-CRC managed resection. <b>Patients methods:</b> We analyzed all by six...
Local failure at the primary site is a major problem after chemoradiotherapy (CRT) in patients with esophageal squamous cell carcinoma (ESCC). Salvage surgery only treatment option curative intent, but it associated high morbidity and mortality. The aim of this study was to evaluate efficacy safety salvage photodynamic therapy (PDT) CRT. Patients histologically proven local limited submucosal layer, without any metastasis definitive CRT (≥50 Gy) for ESCC were enrolled study. PDT began...
To clarify the effectiveness of second-look endoscopy (SLE) at preventing bleeding after gastric endoscopic submucosal dissection (ESD).A multicentre prospective randomised controlled non-inferiority trial was conducted five referral institutions across Japan. Patients with a solitary neoplasm were enrolled. Exclusion criteria previous oesophagogastric surgery or radiation therapy; perforation and administration antithrombotics, steroids non-steroidal anti-inflammatory drugs. assigned to SLE...
<b>Background and study aims:</b> The novel method of image-enhanced endoscopy (IEE) named blue laser imaging (BLI) can enhance the contrast surface vessels using lasers for light illumination. BLI has two IEE modes: high mode (BLI-contrast) use with magnification, bright (BLI-bright), which achieves a brighter image than BLI-contrast yet maintains enhanced visualization vascular that is expected detection tumors from far field view. aim this to clarify effect BLI-bright view compared...
Background and study aim Magnifying narrow-band imaging (M-NBI) is useful for the accurate diagnosis of early gastric cancer (EGC). However, acquiring skill at M-NBI takes substantial effort. An Internet-based e-learning system to teach endoscopic EGC using has been developed. This evaluated its effectiveness. Participants methods was designed as a multicenter randomized controlled trial. We recruited endoscopists participants from all over Japan. After completing Test 1, which consisted...
We retrospectively investigated the efficacy and feasibility of concurrent chemoradiotherapy for patients with severe dysphagia caused by oesophageal squamous cell carcinoma. Concurrent was performed in 57 T3 or T4 disease containing M1 lymph node (LYM) disease. Chemotherapy consisted protracted infusion 5-fluorouracil (5-FU) 400 mg m(-2) 24 h(-1) on days 1-5 8-12, combined 2-h cisplatin (CDDP) 40 1 8. Radiation treatment at a dose 30 Gy 15 fractions mediastinum administered concomitantly...
Local failure after chemoradiotherapy (CRT) remains a major problem for patients with esophageal squamous cell carcinoma (ESCC). The aim of this study was to clarify the long-term results salvage photodynamic therapy (PDT) local failure.Patients were treated CRT, consisting more than 50 Gy irradiation and concurrent chemotherapy. indications PDT as follows: 1) absence lymph-node or distant metastasis CRT; 2) lesion limited T2; 3) refusal by patient undergo esophagectomy; 4) written informed...