A5070159963- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Colorectal Cancer Screening and Detection
- Gastrointestinal disorders and treatments
- Chromatin Remodeling and Cancer
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Diverticular Disease and Complications
- Digestive system and related health
- Genetic factors in colorectal cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Galectins and Cancer Biology
- Nutritional Studies and Diet
- Pancreatic and Hepatic Oncology Research
- Blood Pressure and Hypertension Studies
The University of Tokyo
2016-2025
University of Tokyo Hospital
2016-2025
RELX Group (Netherlands)
2020
Olympus (Japan)
2016
University Gastroenterology
2016
Tokyo University of Science
2001-2009
Wakayama Medical University
2005-2006
Chugai Pharma (United States)
2005
Hy-Line (United States)
2005
Kameda Medical Center
1999
See also: Commentaire de travail S. Ono et al., pp. 661Endoscopy 2009; 41(08): 826-826DOI: 10.1055/s-0032-1306742
Abstract Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2 diabetes 1,2 . Previous metagenomic studies have described characteristics of gut microbiota their roles in metabolizing major nutrients insulin 3–9 In particular, carbohydrate metabolism commensals has been proposed to contribute up 10% host’s overall energy extraction 10 , thereby playing a role pathogenesis obesity prediabetes 3,4,6 Nevertheless, mechanism remains unclear. Here we...
Background and aims: Endoscopic submucosal dissection (ESD) provides a high en bloc resection rate with less invasiveness than surgical for large or scarring gastrointestinal neoplasms. However, detailed outcomes in colorectal ESD are still lacking. The aim of our study was to elucidate short- long-term ESD.
Abstract Purpose: To better understand microRNA miR-21 function in carcinogenesis, we analyzed expression patterns different stages of colorectal cancer development using situ hybridization (ISH). Experimental Design: Locked nucleic acid (LNA)/DNA probes and a biotin-free tyramide signal amplification system were used ISH analyses miRNA expression. Conditions for specific detection determined human cell lines miR-21–expressing lentiviral vectors. Expression was 39 surgically excised tumors...
Background and study aims: Endoscopic submucosal dissection (ESD) is a novel technique used for the treatment of gastrointestinal neoplasia. One its major limitations, however, complication perforation. Patients methods: We included in our all cases perforation that occurred during ESD procedures epithelial neoplasia between February 2000 2005. Clinical outcomes after were investigated. Results: Perforation was experienced at 27 lesions patients (four esophagus, fourteen stomach, seven...
Our study investigated the relationship between gastric cancer development and activity of Helicobacter pylori-associated chronic gastritis or resulting atrophic (CAG). A cohort 4,655 healthy asymptomatic subjects, in whom serum pepsinogen (PG) H. pylori antibody titer had been measured to assess stage gastritis, was followed for up 16 years, investigated. In subjects with a serologically diagnosed stomach (H. pylori-negative/CAG-negative), incidence rate low, at 16/100,000 person-years....
<h3>Background</h3> Epigenetic alterations accumulate in normal-appearing tissues of patients with cancer, producing an epigenetic field defect. Cross-sectional studies show that the degree defect may be associated risk some types especially cancers chronic inflammation. <h3>Objective</h3> To demonstrate, by a multicentre prospective cohort study, metachronous gastric cancer after endoscopic resection (ER) can predicted assessment using methylation levels. <h3>Design</h3> Patients early aged...
<b>Background and study aims:</b> Suitable techniques for the prevention of stricture formation after esophageal endoscopic submucosal dissection (ESD) are still lacking. We investigated efficacy polyglycolic acid (PGA) sheets with fibrin glue to prevent post-ESD stricture. <b>Patients methods:</b> conducted a pilot on total eight consecutive patients who underwent ESD that left mucosal defect more than three-quarters circumference. PGA were attached immediately completion ESD. The primary...
Fatty liver disease (FLD) including non-alcoholic fatty (NAFLD), a rapidly emerging and widely recognized today, is regarded as hepatic manifestation of metabolic syndrome. Helicobacter pylori, one the most common pathogens worldwide, has been reported to be associated with syndrome, but whether there direct association FLD yet unclear. The aim this study was clarify NAFLD causative background factors pylori infection.This cross-sectional Japanese adults who received medical checkups at...
Background Despite the marked increase of diverticulosis, its risk factors have not been adequately elucidated. We therefore aim to identify significantly associated with diverticulosis. also investigate present state diverticulosis in Japan. Methods reviewed medical records from 1990 2010 that included data consecutive 62,503 asymptomatic colonoscopy examinees general population Most recent 3,327 were analyzed 16 background factors. Results Among subjects (47,325 men and 15,178 women; 52.1...
Fos family proteins form stable heterodimers with Jun proteins, and each heterodimer shows distinctive transactivating potential for regulating cellular growth, differentiation, development via AP-1 binding sites. However, the molecular mechanism underlying dimer specificity molecules that facilitate transactivation remain undefined. Here, we show BAF60a, a subunit of SWI·SNF chromatin remodeling complex, is determinant Fos/Jun dimers. BAF60a binds to specific subset using two different...
The technique of endoscopic submucosal dissection (ESD) has recently been developed for en-bloc resection gastric tumors. For oncological reasons and in order to improve the patients' quality life, it may be desirable use same rectal neoplasia.Thirty-five consecutive patients with neoplasia who had a preoperative diagnosis large intraepithelial neoplasias fibrosis or located on folds were enrolled. ESD was carried out previously described stomach, some modifications. efficacy, complications,...
Gastroesophageal reflux disease (GERD) is a very common disorder worldwide, comprised of esophagitis (RE) and non-erosive (NERD). As more than half GERD patients are classified into the NERD group, precise evaluation bothersome epigastric symptoms essential. Nevertheless, compared with many reports targeting endoscopic esophagitis, large-scale studies focusing on have been scarce. To elucidate lifestyle factors affecting symptoms, 19,864 healthy adults in Japan were analyzed. Sub-analyses...
Endoscopic submucosal dissection (ESD) has gradually gained acceptance as one of the standard treatments for early esophageal cancer, well gastric cancer in Japan, but standardization knowledge is still incomplete. The final goal to perform ESD not resect lesion an en bloc fashion, save patient from cancer-related death. Thus, indications should be considered based on entire patient, just target itself, and pre-, peri- postoperative management also very important, technical aspects ESD. In...
This study aimed to elucidate groups at high risk of developing cancer among patients with serologically identified Helicobacter pylori infection and nonatrophic stomach. Annual endoscopy was performed for a mean 5.4 years in 496 asymptomatic middle-aged men who were H. antibody-positive pepsinogen (PG) test-negative. Subjects stratified according the activity pylori-associated gastritis measured by serum levels PG antibody, and/or endoscopic findings rugal hyperplastic (RHG), development...
To clarify the effectiveness of second-look endoscopy (SLE) at preventing bleeding after gastric endoscopic submucosal dissection (ESD).A multicentre prospective randomised controlled non-inferiority trial was conducted five referral institutions across Japan. Patients with a solitary neoplasm were enrolled. Exclusion criteria previous oesophagogastric surgery or radiation therapy; perforation and administration antithrombotics, steroids non-steroidal anti-inflammatory drugs. assigned to SLE...