A5102731064- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Helicobacter pylori-related gastroenterology studies
- Mental Health Research Topics
- Personality Disorders and Psychopathology
- Diet, Metabolism, and Disease
- Esophageal Cancer Research and Treatment
- Identity, Memory, and Therapy
- Perfectionism, Procrastination, Anxiety Studies
- Liver Disease Diagnosis and Treatment
- Personality Traits and Psychology
- Diet and metabolism studies
- Esophageal and GI Pathology
- Cholesterol and Lipid Metabolism
- Mind wandering and attention
- Adipose Tissue and Metabolism
- Meat and Animal Product Quality
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- Peroxisome Proliferator-Activated Receptors
- Stuttering Research and Treatment
- Cardiac Ischemia and Reperfusion
- Protein Hydrolysis and Bioactive Peptides
Showa University
2025
Kishokai Medical Corporation
2025
Kyoto City Hospital
2024
Oita University
2009-2024
Hosei University
2018-2023
National Hospital Organization
2023
Fukui-ken Saiseikai Hospital
2023
University of Tsukuba
2012-2021
Saiseikai Shigaken Hospital
2021
Tokatsu Hospital
2015-2020
We earlier reported that mucosal defect involving over three-fourths of the circumference esophagus after endoscopic resection (EMR) is a risk factor for development stricture. Although balloon dilation (EBD) useful procedure to relieve stricture, there no standard strategy preventing The aim this study was evaluate efficacy and safety preventive EBD.From 1993 2008, 41 consecutive patients with extensive esophageal EMR or submucosal dissection (ESD) were investigated. Preventive EBD carried...
Based on limited experimental data, the attenuation of acoustic waves in partially saturated rocks has been suspected to result from effect fluid flow. Global flow is accompanied by a viscous energy loss, which results waves. In this theoretical study, we explore effects global and gas saturation level wave attenuation. The predicted theory much smaller than that actually supported data for sandstones at low frequencies (≦1000 Hz). technique involves use Biot's equations two interacting...
Gastroesophageal reflux disease (GERD) is a very common disorder worldwide, comprised of esophagitis (RE) and non-erosive (NERD). As more than half GERD patients are classified into the NERD group, precise evaluation bothersome epigastric symptoms essential. Nevertheless, compared with many reports targeting endoscopic esophagitis, large-scale studies focusing on have been scarce. To elucidate lifestyle factors affecting symptoms, 19,864 healthy adults in Japan were analyzed. Sub-analyses...
To clarify the effectiveness of second-look endoscopy (SLE) at preventing bleeding after gastric endoscopic submucosal dissection (ESD).A multicentre prospective randomised controlled non-inferiority trial was conducted five referral institutions across Japan. Patients with a solitary neoplasm were enrolled. Exclusion criteria previous oesophagogastric surgery or radiation therapy; perforation and administration antithrombotics, steroids non-steroidal anti-inflammatory drugs. assigned to SLE...
Background Despite the high prevalence of gastroesophageal reflux disease (GERD), its risk factors are still a subject controversy. This is probably due to inadequate distinction between esophagitis (RE) and non-erosive (NERD), also evaluation adjacent stomach. Our aim therefore define background RE NERD independently, based on Helicobacter pylori infection gastric atrophy. Methods We analyzed 10,837 healthy Japanese subjects (6,332 men 4,505 women, aged 20–87 years) who underwent upper...
The circadian clock is closely related to human health, such as metabolic syndrome and cardiovascular disease. Our previous study revealed that irregular feeding induced abnormal lipid metabolism with disruption of the hepatic clock. We hypothesized breakfast skipping induces abnormalities, adiposity, by altering oscillation metabolism-related genes. Here, we established a delayed first active-phase meal (DFAM) protocol breakfast-skipping model. Briefly, rats were fed high-fat diet during...
Plants biosynthesize a variety of bioactive lipid derivatives, such as green leaf volatiles ( GLV s) and jasmonates JA s). Here we identify lipoxygenase 2 LOX 2) involved in biosynthesis Arabidopsis using mutant lines for each the six isoforms present Arabidopsis. We found that formation five carbon was also dependent on 2. is known to be ; thus, apparently versatile function. The results this study suggested activity suppressed intact cells but activated upon tissue damage support rapid...
Bleeding after endoscopic submucosal dissection (ESD) is a severe adverse event. Recent reports have described the efficacy of shielding method with polyglycolic acid (PGA) sheets and fibrin glue for prevention events ESD. The aim present study was to investigate whether PGA provides additional benefit in preventing post-ESD bleeding compared standard care.This prospective, multicenter, randomized controlled trial. Patients at high risk were enrolled study. Before ESD, patients either group...
A hepatoprotective peptide, pyroglutamyl leucine (pyroGlu-Leu), was identified in wheat gluten hydrolysate through an vivo activity-guided fractionation approach based on D-galactosamine-induced acute hepatitis rats and of peptides with large-scale preparative ampholine-free isoelectric focusing. The active acidic fraction predominantly consisted free pyroglutamic acid. Pyroglutamyl were derivatized phenyl isothiocyanate after removal a residue by pyroglutamate aminopeptidase. derivatives...
Standard care for unresectable locally advanced esophageal squamous cell carcinoma (ESCC) is concurrent chemoradiotherapy, but survival remains limited. Neoadjuvant chemotherapy with docetaxel, cisplatin and fluorouracil (DCF) has demonstrated promising activity, a pathological complete response (CR) of 17 % resectable stage II/III ESCC. Here, we conducted multicenter study to assess the efficacy safety induction DCF followed by CRT in patients ESCC.Eligibility criteria included clinical T4...
Ultrasonic phased array technology, while versatile, often requires complex computing resources and numerous amplifier components. We present a Manually Reconfigurable Phased Array that physically controls transducer position phase, offering simpler alternative to traditional transducers (PAT). Our system uses conductor rod-connected with an underlying plate modulates the phase state through its shape electrode arrangement. This approach enables variable reconstruction reduced computational...
The concept of genome-microbiome interactions, in which the microenvironment determined by host genetic polymorphisms regulates local microbiota, is important pathogenesis human disease. In otolaryngology, resident bacterial microbiota reportedly altered non-infectious ear diseases, such as otitis media pearls and exudative media. We hypothesized that a single-nucleotide polymorphism ATP-binding cassette sub-family C member 11 (ABCC11) gene, determines earwax properties, canal microbiota....
Abstract The infrared spectra of bulk and thin‐film CeO 2 are measured at various conditions by reflection, transmission, thermal‐emission methods. reststrahlen reflectivity analyzed means a two‐oscillator dispersion model, the dielectric properties lattice vibrational discussed. virtual mode (polariton) theory anharmonic ionic crystal slab.
Endoscopic submucosal dissection (ESD) causes artificial ulcers, and there is no consensus regarding the degree of healing in ESD-induced ulcers or optimal duration proton pump inhibitor (PPI) treatment. The aim present study was to investigate rates post-ESD response protective effect 2-week PPI treatment.Between February 2007 March 2010, 75 patients/75 lesions 55 patients/55 were enrolled as interim per-protocol groups, respectively. All patients prescribed rabeprazole (10 mg/day) orally...
Aims: Endoscopic submucosal dissection (ESD) has several advantages over conventional endoscopic mucosal resection, including a higher en bloc resection rate and more accurate pathological estimation. However, ESD is complex procedure that requires advanced skills. The aim of our study to evaluate the efficacy with ligation device (EMR‐L) compared for rectal carcinoid tumors. Methods: Between September 2003 April 2011, 24 tumors in patients treated by or EMR‐L were retrospectively analyzed....
Vonoprazan is a potassium-competitive acid blocker, new type of acid-suppressing drug, and has recently become available for peptic ulcers, gastroesophageal reflux disease, Helicobacter pylori (H. pylori) eradication. Its efficacy H. eradication been reported. However, the evidence its feasibility remains limited. We aimed to compare feasibility, effectiveness safety vonoprazan-based triple therapy with conventional proton pump inhibitor (PPI)-based in multicenter clinical practice.We...
Green leaf volatiles (GLVs) consisting of six-carbon aldehydes, alcohols, and their esters, are biosynthesized through the action fatty acid hydroperoxide lyase (HPL), which uses hydroperoxides as substrates. GLVs form immediately after disruption plant tissues by herbivore attacks mechanical wounding play a role in defense against attackers that attempt to invade wounds. The fates physiological significance counterparts HPL reaction, 12/10-carbon oxoacids formed from 18/16-carbon...
Although magnifying endoscopy with narrow-band imaging (ME-NBI) is reported to be useful for delineating the horizontal extent of early gastric cancers (EGCs), there are few reports which have objectively demonstrated superiority ME-NBI over chromoendoscopy indigo carmine this purpose. We conducted an exploratory comparison diagnostic accuracy both modalities delineation EGCs using prospectively collected data, and clarified clinicopathological features related inaccurate evaluation...
Abstract The aim of this study was to evaluate whether frailty associated with 6-month mortality in older adults who were admitted the intensive care unit (ICU) an illness requiring emergency care. investigation a prospective, multi-center, observational conducted among ICUs 17 participating hospitals. Patients ≥ 65 years age ICU directly from department visit assessed determine their baseline Clinical Frailty Scale (CFS) scores before and surveyed 6 months after admission. Among 650...