A5075060125- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Diverticular Disease and Complications
- Gastrointestinal Tumor Research and Treatment
- Epigenetics and DNA Methylation
- Digestive system and related health
- Eosinophilic Esophagitis
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Gastrointestinal disorders and treatments
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Esophageal and GI Pathology
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Urinary Bladder and Prostate Research
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Plant-Derived Bioactive Compounds
- Biomedical Research and Pathophysiology
- Salivary Gland Tumors Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Gastrointestinal Bleeding Diagnosis and Treatment
Hoshi University
2023-2024
The University of Tokyo
2014-2023
Kobe University
2021
Maruishi Pharmaceutical (Japan)
2019
Japanese Red Cross Kumamoto Hospital
2018
RELX Group (Netherlands)
2018
Hitachi General Hospital
2013-2014
University of Shizuoka
2006-2008
Nikon (Japan)
1997
Background Despite the marked increase of diverticulosis, its risk factors have not been adequately elucidated. We therefore aim to identify significantly associated with diverticulosis. also investigate present state diverticulosis in Japan. Methods reviewed medical records from 1990 2010 that included data consecutive 62,503 asymptomatic colonoscopy examinees general population Most recent 3,327 were analyzed 16 background factors. Results Among subjects (47,325 men and 15,178 women; 52.1...
Gastroesophageal reflux disease (GERD) is a very common disorder worldwide, comprised of esophagitis (RE) and non-erosive (NERD). As more than half GERD patients are classified into the NERD group, precise evaluation bothersome epigastric symptoms essential. Nevertheless, compared with many reports targeting endoscopic esophagitis, large-scale studies focusing on have been scarce. To elucidate lifestyle factors affecting symptoms, 19,864 healthy adults in Japan were analyzed. Sub-analyses...
Background Several previous studies have suggested that Helicobacter pylori (H. pylori) infection affects the serum lipid profile. However, it remains controversial and mechanism has not been elucidated. The purpose of this study is to use an epidemiological perspective evaluate association between H. Methods Multivariate analysis was performed using data profile, status pylori, fitness/lifestyle habits, various subjects’ characteristics which were derived from 15,679 generally healthy...
The presence of intestinal metaplasia (IM) is a risk factor for gastric cancer. However, it still controversial whether IM itself precancerous or paracancerous. Here, we aimed to explore the nature by analysing epigenetic alterations.
Intestinal metaplasia induced by ectopic expression of caudal‐type homeobox ( CDX )2 and/or 1 ) is frequently observed around gastric cancer GC ). Abnormal also in and suggests that inappropriate gastrointestinal differentiation plays essential roles tumorigenesis, but their on tumorigenesis remain unelucidated. Publicly available databases show patients with higher have significantly better clinical outcomes. We introduced 2 genes separately into ‐originated MKN 7 TMK cells deficient ....
The increasing usage of proton pump inhibitors (PPIs) has been reported worldwide, but information on PPI use in East Asia is inadequate. This study aimed to examine the trends Japan, along with changes histamine H2 receptor antagonist (H2RA) use, disease rate reflux esophagitis, and prevalence upper gastrointestinal symptoms. We analyzed 217,712 healthy subjects (127,607 men 90,105 women; 51.4 ± 9.7 years old) participating health check program from 2010 2019. Various symptoms were...
Double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR) is one of the most widely conducted gastric cancer screening methods. It has been executed to find cancer, but not usually detect premalignant atrophic mucosa stomach. To understand meaning UGI-XR-based gastritis, we analyzed its association with several causative factors including Helicobacter pylori (HP) infection.We evaluated 6,901 healthy adults in Japan. gastritis was diagnosed based on irregular shape areae...
Abstract Background Autoimmune gastritis (AIG) is a prevalent chronic inflammatory disease with oncogenic potential that causes destruction of parietal cells and severe mucosal atrophy. We aimed to explore the distinctive gene expression profiles, activated signaling pathways, their underlying mechanisms. Methods A comprehensive analysis was conducted using biopsy specimens from AIG, Helicobacter pylori -associated (HPG), non-inflammatory normal stomachs. Gastric cancer cell lines were...
Anticholinergic agents such as oxybutynin are clinically useful in the treatment of overactive bladder. However, oral administration is frequently accompanied by side effects dry mouth, and novel bladder-selective anticholinergic solifenacin tolterodine now under development. The aim present study was to characterize suppression cholinergic salivation exocrine muscarinic receptor binding on mice comparison with those oxybutynin. Results showed that both drugs produced a significant increase...
Background/Aims: Gastroesophageal reflux disease (GERD)-related disorders of systemic sclerosis (SSc) patients have not been adequately investigated. Methods: Sixty-six SSc (5 males and 61 females; 56.6 ± 14.6 years old) who underwent esophagogastroduodenoscopy were analyzed on the basis 16 background factors. They additionally compared with 116 matched non-SSc subjects controlling age, sex, use proton pump inhibitors (PPIs). Results: The mean duration 66 was 5.1 8.1 years, their breakdown...
Abstract The objective of this study was to elucidate the molecular background sessile serrated adenoma/polyp (SSA/P) endoscopically resected with comprehensive gene expression analysis. Gene profiling performed for 10 tumor‐normal pairs SSA/P. Cluster analysis, set enrichment analysis (GSEA), and consensus subtype (CMS) classification colorectal cancer (CRC) were applied our transcriptome Unsupervised cluster showed that profile SSA/Ps is different from adjacent normal epithelial cells,...