A5024713150- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Hepatitis B Virus Studies
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Pancreatitis Pathology and Treatment
- Systemic Lupus Erythematosus Research
- Genetic factors in colorectal cancer
- HIV/AIDS drug development and treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer Treatment and Pharmacology
- Biliary and Gastrointestinal Fistulas
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Liver Disease and Transplantation
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
Hokkaido University Hospital
2016-2025
Hokkaido University
2016-2025
National Cancer Center Hospital East
2022-2024
Chibaken Saiseikai Narashino Hospital
2011-2024
Himeji Red Cross Hospital
2023
John Wiley & Sons (United Kingdom)
2023
University of Oxford
2023
Hudson Institute
2023
John Wiley & Sons (United States)
2023
Tokyo Metropolitan Bokutoh Hospital
2022-2023
Recently it has been postulated that mitochondrial ATP-sensitive K+ (mitoKATP) channels rather than sarcolemmal KATP (sarcKATP) are important as end effectors and/or triggers of ischemic preconditioning (IPC). To define the pathophysiological significance sarcKATP channels, we conducted functional experiments using Kir6.2-deficient (KO) mice. Metabolic inhibition with glucose-free, dinitrophenol-containing solution activated current and shortened action potential duration in ventricular...
Genotype 2 hepatitis C virus (HCV) accounts for up to 30% of chronic HCV infections in Japan. The standard care patients with genotype - peginterferon and ribavirin 24 weeks is poorly tolerated, especially among older those advanced liver disease. We conducted a phase 3, open-label study assess the efficacy safety an all-oral combination NS5B polymerase inhibitor sofosbuvir infection enrolled 90 treatment-naïve 63 previously treated at 20 sites All received 400 mg plus (weight-based dosing)...
A growing body of evidence suggests that non-viral hepatocellular carcinoma (HCC) might benefit less from immunotherapy.We carried out a retrospective analysis prospectively collected data consecutive patients with advanced HCC, treated atezolizumab plus bevacizumab, lenvatinib, or sorafenib, in 36 centers 4 countries (Italy, Japan, Republic Korea, and UK). The primary endpoint was overall survival (OS) bevacizumab versus lenvatinib. Secondary endpoints were progression-free (PFS) OS PFS...
Recently it has been postulated that mitochondrial ATP-sensitive K+ (mitoKATP) channels rather than sarcolemmal KATP (sarcKATP) are important as end effectors and/or triggers of ischemic preconditioning (IPC). To define the pathophysiological significance sarcKATP channels, we conducted functional experiments using Kir6.2-deficient (KO) mice. Metabolic inhibition with glucose-free, dinitrophenol-containing solution activated current and shortened action potential duration in ventricular...
The precise subcellular localization of ion channels is often necessary to ensure rapid and efficient integration both intracellular extracellular signaling events. Recently, we have identified lipid raft association as a novel mechanism for the sorting specific voltage-gated K+channels regions membrane rich in complexes. Here, demonstrate isoform-specific targeting K+ (Kv) distinct populations with finding that Kv1.5 specifically targets caveolae. Multiple lines evidence indicate Kv2.1...
Abstract —ATP-sensitive potassium (K ATP ) channels were discovered in ventricular cells, but their roles the heart remain mysterious. K have also been found numerous other tissues, including vascular smooth muscle. Two pore-forming subunits, Kir6.1 and Kir6.2, contribute to diversity of channels. To determine which subunits are operative cardiovascular system functional roles, we characterized effects pharmacological + channel openers (KCOs, ie, pinacidil, P-1075, diazoxide)...
A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti‐viral activity against influenza virus, adenovirus, coxsackievirus, and human immunodeficiency virus. However, it remains be determined whether curcumin can inhibit replication of hepatitis C virus (HCV). In this study, we showed that decreases HCV gene expression via suppression Akt‐SREBP‐1 activation, not by NF‐κB pathway. The combination IFNα exerted profound inhibitory effects on replication....
Treatment with anti-TNF-alpha MAb has been accepted as a successful maintenance therapy for patients inflammatory bowel diseases (IBD). Moreover, it recently reported that blockade of TNF receptor (TNFR) 1 signaling in infiltrating hematopoietic cells may prevent the development colitis-associated cancer (CAC). However, remains unclear whether TNF-alpha epithelial is involved CAC. To investigate this, we studied effects an animal model CAC by administration azoxymethane (AOM) followed...
Interferons (IFNs) and the interferon-stimulated genes (ISGs) play a central role in antiviral responses against hepatitis C virus (HCV) infection. We have reported previously that ISGs, including guanylate binding protein 1 (GBP-1), interferon alpha inducible (IFI)-6-16, IFI-27, inhibit HCV subgenomic replication. In this study we investigated effects of these ISGs cell culture their direct molecular interaction with viral proteins. replication production were suppressed significantly by...
Hepatitis C virus (HCV) infection blocks cellular interferon (IFN)-mediated antiviral signaling through cleavage of Cardif by HCV-NS3/4A serine protease. Like NS3/4A, NS4B protein strongly IFN-β production mediated retinoic acid-inducible gene I (RIG-I); however, the underlying molecular mechanisms are not well understood. Recently, stimulator genes (STING) was identified as an activator RIG-I signaling. STING possesses a structural homology domain with flaviviral NS4B, which suggests direct...
The transcription factor Atoh1/Hath1 plays crucial roles in the differentiation program of human intestinal epithelium cells (IECs). Although previous studies have indicated that Notch signal suppresses IEC, mechanism by which it does so remains unknown. This study shows undifferentiated state is maintained suppression Hath1 gene intestine. To assess effect signaling, doxycycline-induced expression intracellular domain (NICD) and Hes1 were generated LS174T. was analyzed quantitative...
There are no approved drug treatments for liver fibrosis and nonalcoholic steatohepatitis (NASH), an advanced stage of which has rapidly become a major cause cirrhosis. Therefore, development anti-inflammatory antifibrotic therapies is desired. Mesenchymal stem cell- (MSC-) based therapy, been extensively investigated in regenerative medicine various organs, can reportedly achieve therapeutic effect NASH via paracrine action. Extracellular vesicles (EVs) encompass variety released by cells...
Background & AimsThere is still a risk for hepatocellular carcinoma (HCC) development after eradication of hepatitis C virus (HCV) infection with antiviral agents. We investigated genetic factors associated the HCC in patients sustained virologic response (SVR) to treatment chronic HCV infection.MethodsWe obtained genomic DNA from 457 Japan SVR interferon-based 2007 through 2015. conducted genome-wide association study (GWAS), followed by replication analysis 79 candidate single nucleotide...
Abstract Background In Japan, there have been approximately 50 000 deaths from gastric cancer annually for over 40 years with little variation. It has reported that most cancers in Japan are caused by Helicobacter pylori infection. H. eradication therapy was approved patients chronic gastritis the Japanese national health insurance scheme February 2013 an endoscopic diagnosis of is positive . We examined effect on death rate 4 after expansion coverage. Aim conducted epidemiological study and...