A5051503780- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Esophageal Cancer Research and Treatment
- Gastrointestinal disorders and treatments
- Gastrointestinal motility and disorders
- Esophageal and GI Pathology
- Colorectal Cancer Screening and Detection
- Metastasis and carcinoma case studies
- Tissue Engineering and Regenerative Medicine
- Congenital gastrointestinal and neural anomalies
- Pelvic floor disorders treatments
- Colorectal Cancer Surgical Treatments
- Mesenchymal stem cell research
- Venous Thromboembolism Diagnosis and Management
- Cancer Treatment and Pharmacology
- Gastrointestinal Tumor Research and Treatment
- Mycobacterium research and diagnosis
- Biliary and Gastrointestinal Fistulas
- Hematopoietic Stem Cell Transplantation
- Cytomegalovirus and herpesvirus research
- Machine Learning in Bioinformatics
- Veterinary medicine and infectious diseases
- Molecular Biology Techniques and Applications
Hakodate National Hospital
2019-2024
National Hospital Organization
2019-2024
Japan Cancer Society
2023-2024
Hokkaido University Hospital
2018-2022
Hokkaido University
2000-2020
Chiba Cancer Center
2017
Kanagawa Prefectural Hospital Organization
2017
Kanagawa Cancer Center
2017
RELX Group (Netherlands)
2017
Toranomon Hospital
2017
Abstract Background In Japan, there have been approximately 50 000 deaths from gastric cancer annually for over 40 years with little variation. It has reported that most cancers in Japan are caused by Helicobacter pylori infection. H. eradication therapy was approved patients chronic gastritis the Japanese national health insurance scheme February 2013 an endoscopic diagnosis of is positive . We examined effect on death rate 4 after expansion coverage. Aim conducted epidemiological study and...
Background: Linked color imaging (LCI) is a new image-enhanced endoscopy technique that allows users to recognize slight differences in mucosal color. Objective: To compare the performance of LCI with white light (WLI) detecting neoplastic lesions upper gastrointestinal tract. Design: A controlled, multicenter trial randomization using minimization. (University Hospital Medical Information Network Clinical Trials Registry: UMIN000023863) Setting: 16 university hospitals and 3 tertiary care...
Prophylactic clipping has been widely used to prevent post-procedural bleeding in colon polypctomy. However, its efficiency not confirmed and there is no consensus on the usefulness of prophylactic clipping. The aim present study was evaluate preventive effect post-polypectomy bleeding.A multicenter randomized controlled conducted from January 2012 July 2013 Japan. Patients who had polyps <2 cm diameter were divided into a group non-clipping by cluster randomization. After endoscopic...
Background and Aims: Recently, there have been some reports that image-enhanced endoscopy may improve detection of gastric intestinal metaplasia (GIM). Our aim was to determine the usefulness linked color imaging (LCI) for GIM. Methods: In prospectively recruited patients, whole antrum observed by white light (WLI) followed LCI. When a whitish flat elevation (WFE) in WLI lavender sign (LCS) LCI were detected, target biopsies performed after Random patients who had neither WFE nor LCS. The...
Chronic constipation is a common gastrointestinal disorder in older adults, and it very important to manage chronic constipation. However, evaluating these subjective symptoms extremely difficult cases where patients are unable express their because of cognitive or physical impairment. Hence, necessary observe the patient's colonic faecal retention using objective methods. Ultrasonography observation for useful diagnosing effectiveness treatment. Since there was no standard protocol...
For endoscopic interventions, heparin bridging therapy is recommended in patients who are at high risk from interruption of antithrombotic therapy. Although has been reported to be effective preventing thrombosis, several reports have raised concerns about increased bleeding. The aim this study was clarify complications hepari therapeutic endoscopy.A nationwide multicenter survey using questionnaire performed undergoing endoscopy with bridging. Patients underwent without were considered as...
A 56-year-old man with gastroesophageal reflux disease (GERD) was referred to our hospital. Esophagogastroduodenoscopy (EGD) revealed no evidence of any polypoid lesions in the stomach, and patient had history Helicobacter pylori infection. He received omeprazole (20 mg) once daily for GERD. EGD performed at 1 year after start administration, this time, gastric hyperplastic polyps (GHPs) were detected. The GHPs increased size as treatment continued, but they markedly decreased following...
Abstract Background Clarithromycin (CAM) resistance is a major contributor to the failure eradicate Helicobacter pylori ( H . ). The mixed‐infection ratio of CAM‐susceptible and CAM‐resistant strains differs among individuals. Pyrosequencing analysis can be used quantify gene mutations at position each 2142 2143 23S rRNA in intragastric fluid samples. Herein, we aimed clarify impact rate mixed infection with on success CAM‐containing eradication therapy. Materials Methods Sixty‐four...
Abstract Background Linked color imaging (LCI) is a new image enhancement technology that facilitates the recognition of subtle differences in mucosal color. In large‐scale, multicenter randomized controlled trial LCI‐FIND, LCI demonstrated good diagnostic performance for detection tumor lesions upper gastrointestinal tract. The aim present study was to exploratively evaluate according H. pylori infection status as subanalysis LCI‐FIND trial. Methods patients were randomly allocated receive...
Background and Aim Use of proton pump inhibitors ( PPI ) is histologically associated with oxyntic gland dilatations. Two interesting mucosal changes are often detected endoscopically in patients who use : gastric cracked mucosa GCM cobblestone‐like GCSM ). The aim the present study was to clarify relationship between these changes. Methods This a single‐center observational study. All successive subjects underwent routine esophagogastroduodenoscopy EGD August November 2014 Hokkaido...
Although there are many Helicobacter pylori (H. pylori) diagnostic methods, the culture and antibiotic susceptibility test is an important method for selecting most effective H. eradication regimen. However, this complicated takes several days; therefore, development of a rapid simple required. Eradication failure due to clarithromycin (CAM) resistance should also be considered. In study, we report clinical evaluation point-of-care testing (POCT) kit using intragastric fluid, novel detecting...
Background and study aims Linked color imaging (LCI) is a new image-enhancing technique that facilitates the differentiation of slight differences in mucosal tone. We performed an exploratory analysis to evaluate diagnostic capability LCI ultraslim endoscopy, using data from patients examined LCI-Further Improving Neoplasm Detection upper gastrointestinal (LCI-FIND) trial, large-scale, multicenter, randomized controlled trial demonstrated for detecting neoplastic lesions tract. Patients...
Heparin bridging therapy (HBT) is indeed related to a high frequency of bleeding after endoscopic mucosal resection (EMR). In this study, our aim was investigate clinical impact management oral anticoagulants without HBT in colonic EMR.From data for patients who underwent consecutive EMR, the relationships patient factors and procedural with risk were analysed. Our antithrombotic agents based on shortest cessation as follows: administration warfarin generally continued within therapeutic...
The aim of this post-hoc analysis in a randomized, controlled, multicenter trial was to evaluate the visibility upper gastrointestinal (UGI) neoplasms detected using linked color imaging (LCI) compared with those white light (WLI).The UGI neoplasm images obtained both WLI and LCI subjectively reviewed, median difference (ΔE) between each lesion surrounding mucosa according CIE L*a*b* space evaluated objectively. Multivariate logistic regression performed identify factors associated that were...
Chronic constipation is a common gastrointestinal disorder, and management crucial. Computed tomography (CT) useful for evaluating rectal fecal mass but limited owing to radiation exposure, cost, inaccessibility at certain facilities. Ultrasonography (US) avoids these pitfalls, it unknown whether accurately assesses feces. In this study, we evaluated the diagnostic performance of US compared with CT as gold standard assessing
Chronic constipation is a common gastrointestinal disorder, and its management critical. However, it extremely difficult to assess subjective symptoms when patients are unable report them due cognitive or physical disabilities, especially in cases of with incurable geriatric, pediatric, palliative, psychiatric, neurological diseases. We had previously established protocol for observing assessing rectal fecal retention using ultrasonography classifying into three categories based on the...
Abstract Background Mesenchymal stem cells (MSCs) are valuable in regenerative medicine, and MSC culture supernatant (MSC-CS) reportedly inhibits inflammation fibrosis. We investigated whether colorectal luminal stricture develops after circumferential endoscopic submucosal dissection (ESD) the colorectum, development of could be prevented by using MSC-CS enema. Methods In first experiment, we performed ESD rectums or distal colons pigs (n = 4 each group). sacrificed on Day 22 measured...
To date, no cases of vonoprazan-associated gastric mucosal redness have been reported, and its endoscopic pathological features remain largely unclear. We report four redness. In all cases, esophagogastroduodenoscopy (EGD) demonstrated linear or spotty that newly appeared in the greater curvature middle body after initiation vonoprazan, which disappeared discontinuation. A tissue biopsy taken from mucosa with revealed inflammatory cell infiltration, parietal protrusions (PCPs), oxyntic gland...
Eosinophilic gastroenteritis (EGE)-associated duodenal ulcer is rare and its endoscopic pathological features remain poorly described. A 15-year-old boy was referred to our hospital for further examination treatment of ulcer. Esophagogastroduodenoscopy (EGD) revealed two A2-stage ulcers on the bulb. biopsy marked infiltration eosinophils, suggestive EGE-associated ulcers. Thus, with crushed budesonide (9 mg/day) started. EGD healing seven months after treatment. To knowledge, this first...