A5101405899- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Nuclear Materials and Properties
- Fusion materials and technologies
- Cervical Cancer and HPV Research
- Telomeres, Telomerase, and Senescence
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Endometrial and Cervical Cancer Treatments
- Gastrointestinal motility and disorders
- Estrogen and related hormone effects
- Uterine Myomas and Treatments
- RNA Interference and Gene Delivery
- Esophageal Cancer Research and Treatment
- Nuclear reactor physics and engineering
- Endometriosis Research and Treatment
- Cancer Research and Treatments
- Ovarian cancer diagnosis and treatment
- Cancer Cells and Metastasis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Virus-based gene therapy research
- Magnetic and transport properties of perovskites and related materials
- Menopause: Health Impacts and Treatments
- Stress Responses and Cortisol
- Renal and related cancers
Hokkaido University Hospital
2021-2025
Osaka University
1985-2024
National Cancer Center Hospital East
2022-2024
Kushiro Rosai Hospital
2022-2023
Asahi General Hospital
2023
Tokushima University
2023
Hokkaido University
2001-2022
National Hospital Organization Hokkaido Medical Center
2021
Keiyukai Sapporo Hospital
2021
Sapporo Kosei General Hospital
2021
Human cytochrome P450 (CYP) 1B1 is a key enzyme in the metabolism of 17beta-estradiol (E2). CYP1B1 mainly expressed endocrine-regulated tissues, such as mammary, uterus, and ovary. Because many CYP enzymes are likely to be induced by substrates themselves, we examined whether human expression regulated E2 present study. Real-time reverse transcription-PCR analysis revealed that treatment with 10 nM for 12 h mRNA estrogen receptor (ER)-positive MCF-7 cells. Luciferase reporter assays using...
Human CYP2A6, which is predominantly expressed in liver, a key enzyme responsible for the metabolism of nicotine, coumarin, and some pharmaceutical drugs. CYP2A6 also sex steroid-responsive tissues such as breast, ovary, uterus, testis, adrenal grand. In this study, we examined regulation <i>CYP2A6</i> gene by estrogen. Reverse transcription-polymerase chain reaction (RT-PCR) assays revealed that mRNA was induced estradiol estrogen receptor (ER)-positive MCF-7 (2.9-fold) HepG2 (1.3-fold)...
Symptomatic uterine leiomyoma is associated with irregular bleeding, anemia, and recurrent pregnancy loss. African-American women develop leiomyomas at an earlier age higher frequency compared Caucasian-American or other races; however, the underlying mechanism for this discrepancy unknown.Our objective was to determine whether gene targets of emerging therapeutics such as aromatase inhibitors antiprogestins, which reduce tumor size symptoms, are differentially expressed in tissues (n = 31),...
A propanol-bridged octaazacryptand (26-hydroxy-1,4,7,10,13,16,19,22-octaazabicyclo[11.11.3]heptacosane, HL) has been synthesized from diethylenetriamine and [2-oxo-6-(aminomethyl)morpholyl]-N,N',N'-triacetic acid triethyl ester by refluxing in MeOH followed BH3·THF reduction. This forms a novel dinuclear zinc(II) cryptate (Zn2L) (L = alkoxide form of aqueous solution. The X-ray crystal structure the showed each ion distorted trigonal-bipyramidal environment involving two NH's an O- anion as...
Abstract Background : Whether gastric acid secretion decreases with age is still controversial. With the discovery of Helicobacter pylori , association this bacterium has also been discussed. The aim study was to investigate relationship between secretion, and H. infection. Methods presence infection, grade fundic atrophic gastritis (FAG), were investigated in 280 subjects without localized lesions upper gastrointestinal tract. infection confirmed by Giemsa immunohistochemical staining, FAG...
Abstract In the present study we characterized in detail expression of aromatase P450 leiomyomas to determine role situ estrogen growth advantage leiomyomas. The levels transcripts were determined by quantitative RT-PCR be significantly higher than corresponding myometrium. overexpression was also confirmed Western blot analysis. estimated size immunoreactive 58 kDa, similar that placenta. To identify a cell type express leiomyomas, histological specimens stained for using polyclonal...
Recent clinical studies have revealed the treatment of diabetic patients with sodium glucose co-transporter2 (SGLT2) inhibitors to reduce incidence cardiovascular events. Using nicotinamide and streptozotocin (NA/STZ) -treated ApoE KO mice, we investigated effects short-term (seven days) SGLT2 inhibitor luseogliflozin on mRNA levels related atherosclerosis in aorta, as well examining long-term (six months) development. Eight-week-old mice were treated NA/STZ induce diabetes mellitus, then...