A5043334395- Signaling Pathways in Disease
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Apelin-related biomedical research
- Helicobacter pylori-related gastroenterology studies
- Gout, Hyperuricemia, Uric Acid
- Aldose Reductase and Taurine
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Sirtuins and Resveratrol in Medicine
- Alcohol Consumption and Health Effects
- Digestive system and related health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Endoplasmic Reticulum Stress and Disease
- Gastrointestinal motility and disorders
- Peptidase Inhibition and Analysis
- NF-κB Signaling Pathways
- Inflammasome and immune disorders
- Ubiquitin and proteasome pathways
- Macrophage Migration Inhibitory Factor
- IL-33, ST2, and ILC Pathways
- Influenza Virus Research Studies
- Diabetes Treatment and Management
- Biochemical and Molecular Research
Tulane University
2017-2025
Hiroshima University
2013-2024
Southeast Louisiana Veterans Health Care System
2022
Japan Society for the Promotion of Science
2021
Tula University
2019
Insulin resistance with elevated glucose is a risk factor for non-alcoholic steatohepatitis (NASH). We investigated the effects of sodium cotransporter 2 (SGLT2) inhibitor luseogliflozin on NASH development using rodent model.Mice were treated both nicotinamide and streptozotocin (NA/STZ) to reduce insulin secretory capacity, then fed high fat diet containing trans fatty acids (HFDT) 8 weeks. The NA/STZ HFDT-fed mice divided into two groups, either or untreated, during this period....
Gut microbiota alterations are associated with various disorders. In this study, gut changes were investigated in a methionine-choline-deficient (MCD) diet-induced nonalcoholic steatohepatitis (NASH) rodent model, and the effects of administering Lactobacillus casei strain Shirota (LcS) on development NASH also investigated. Mice divided into three groups, given normal chow diet (NCD), MCD diet, or plus daily oral administration LcS for 6 wk. analyses groups revealed that lactic acid...
Recent clinical studies have revealed the treatment of diabetic patients with sodium glucose co-transporter2 (SGLT2) inhibitors to reduce incidence cardiovascular events. Using nicotinamide and streptozotocin (NA/STZ) -treated ApoE KO mice, we investigated effects short-term (seven days) SGLT2 inhibitor luseogliflozin on mRNA levels related atherosclerosis in aorta, as well examining long-term (six months) development. Eight-week-old mice were treated NA/STZ induce diabetes mellitus, then...
Xanthine oxidase (XO) is an enzyme involved in the production of uric acid (UA) from purine nucleotides. Numerous recent studies have revealed likelihood metabolic syndrome including nonalcoholic fatty liver disease (NAFLD) or steatohepatitis (NASH) to be related hyperuricemia. However, it remains unclear whether elevated serum UA during development NAFLD NASH a cause consequence these diseases. In this study, XO inhibitor febuxostat was administered two types model mice. Febuxostat exerted...
Recently, clinical studies have shown the protective effects of sodium glucose co-transporter2 (SGLT2) inhibitors against progression diabetic nephropathy, but underlying molecular mechanisms remain unclear. Diabetic mice were prepared by injecting nicotinamide and streptozotocin, followed high-sucrose diet feeding (NA/STZ/Suc mice). The SGLT2 inhibitor canagliflozin was administered as a 0.03% (w/w) mixture in for 4 weeks. Then, various parameters on nephropathy investigated. Canagliflozin...
Tissue regenerative responses involve complex interactions between resident structural and immune cells. Recent reports indicate that accumulation of senescent cells during injury repair contributes to pathological tissue fibrosis. Using tissue-based spatial transcriptomics proteomics, we identified upregulation the checkpoint protein, cytotoxic T-lymphocyte associated protein 4 (CTLA4) on CD8+ T adjacent regions active fibrogenesis in human idiopathic pulmonary fibrosis (IPF) a murine model...
Carnosic acid (CA), carnosol (CL) and rosmarinic (RA), components of the herb rosemary, reportedly exert favorable metabolic actions. This study showed that both CA CL, but not RA, induce significant phosphorylation AMP-dependent kinase (AMPK) its downstream acetyl-CoA carboxylase 1 (ACC1) in HepG2 hepatoma cells. Glucose-6-phosphatase (G6PC) phosphoenolpyruvate carboxykinase (PCK1), rate-limiting enzymes hepatic gluconeogenesis, are upregulated by forskolin stimulation, this upregulation...
Hyperuricemia has been recognized as a risk factor for insulin resistance well one of the factors leading to diabetic kidney disease (DKD). Since DKD is most common cause end-stage renal disease, we investigated whether febuxostat, xanthine oxidase (XO) inhibitor, exerts protective effect against development DKD. We used KK-Ay mice, an established obese rodent model. Eight-week-old mice were provided drinking water with or without febuxostat (15 μg/mL) 12 weeks and then subjected...
Nonalcoholic steatohepatitis (NASH) is a disorder characterized by hepatic lipid accumulation followed the inflammation-induced death of hepatocytes and fibrosis. In this process, oxidative stress contributes to induction several inflammatory cytokines including TNF- α IL-1 β in macrophages, while, hepatocytes, NF- κ B reportedly induces expressions cell survival genes for protection from apoptosis. Recently, it was reported that new ubiquitin ligase complex termed linear chain assembly...
Prostate cancer initially develops in an androgen-dependent manner but, during its progression, transitions to being androgen-independent the advanced stage. Pin1, one of peptidyl-prolyl cis/trans isomerases, is reportedly overexpressed prostate cancers and considered contribute accelerated cell growth, which may be major factors contributing their growth. Thus, we investigated how Pin1 modulates gene expressions both lines using microarray analysis. In addition, effects Juglone, a...
Several lines of evidence have suggested a role gut microbiota in the etiology nonalcoholic steatohepatitis (NASH). NASH subjects reportedly showed prolonged orocecal transit time coexistent with small intestinal bacterial overgrowth. We considered possibility that enhanced gastrointestinal motility would influence and thus investigated effects gastroprokinetic agent mosapride citrate (MC) on development using methionine-choline deficient (MCD) diet-fed rodent model. Mice were divided into...
The prolyl isomerase Pin1 expression level is reportedly increased in most malignant tissues and correlates with poor outcomes. On the other hand, acetyl CoA carboxylase 1 (ACC1), rate limiting enzyme of lipogenesis also abundantly expressed cancer cells, to satisfy demand for fatty acids (FAs) needed rapid cell proliferation. We found levels correlate positively ACC1 human prostate cancers, we focused on relationship between ACC1. Notably, it was demonstrated that associates but not 2...
Highlights•Adipocyte Pin1 increases in response to obesity development•Pin1 KO mice are resistant development and cold exposure-induced hypothermia•Pin1 binds promotes the degradation of PRDM16•Pin deletion primary adipocytes upregulates thermogenic gene expressionsSummaryNon-shivering thermogenesis provides defense against low temperatures development, but underlying regulatory mechanism remains be fully clarified. Based on both markedly increased expression states excess nutrition...
Abstract The Trk-fused gene (TFG) is reportedly involved in the process of COPII-mediated vesicle transport and missense mutations TFG cause several neurodegenerative diseases including hereditary motor sensory neuropathy with proximal dominant involvement (HMSN-P). high coincidence ratio between HMSN-P diabetes mellitus suggests to have an important role(s) glucose homeostasis. To examine this possibility, β-cell specific knockout mice (βTFG KO) were generated. Interestingly, βTFG KO...
Recent clinical studies have demonstrated the protective effect of xanthine oxidase (XO) inhibitors against chronic kidney diseases, although underlying molecular mechanisms remain unclear. However, to date, neither nor basic research has been carried out elucidate efficacy XO inhibitor administration for IgA nephropathy. We thus investigated whether febuxostat, an inhibitor, exerts a development nephropathy, using gddY mice as nephropathy rodent model. Eight-week-old were provided drinking...
Type 17 cytokines have been strongly implicated in mucosal immunity, part by regulating the production of antimicrobial peptides. Using a mouse model Citrobacter rodentium infection, which causes colitis, we found that intestinal IL-17RA and IL-17RC were partially required for control infection colon IL-17 regulates luminal hydrogen peroxide as well expression Tnsf13 Reduced Tnfsf13 was associated with profound defect generating C. rodentium-specific IgA+ Ab-secreting cells. Taken together,...