A5055189572- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Endometrial and Cervical Cancer Treatments
- Pancreatic function and diabetes
- Lipid metabolism and disorders
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Colorectal Cancer Surgical Treatments
- Cancer Treatment and Pharmacology
- Cerebral Venous Sinus Thrombosis
- Clostridium difficile and Clostridium perfringens research
- Radiation Dose and Imaging
- Management of metastatic bone disease
- Gastrointestinal motility and disorders
- Renal cell carcinoma treatment
- Metabolism, Diabetes, and Cancer
- Multiple and Secondary Primary Cancers
- Glaucoma and retinal disorders
- Pituitary Gland Disorders and Treatments
- Colorectal and Anal Carcinomas
- Signaling Pathways in Disease
- Gout, Hyperuricemia, Uric Acid
- Prostate Cancer Treatment and Research
Hiroshima University
2011-2019
Sakai Municipal Hospital
2018
Japanese Foundation For Cancer Research
2017
The Cancer Institute Hospital
2016-2017
Ogikubo Hospital
2017
Osaka University
2015-2016
Tokyo Medical University
2012
The Institute of Medical Science, Asahi Life Foundation
2011
The University of Tokyo
2011
Dean McGee Eye Institute
1990-1991
Gut microbiota alterations are associated with various disorders. In this study, gut changes were investigated in a methionine-choline-deficient (MCD) diet-induced nonalcoholic steatohepatitis (NASH) rodent model, and the effects of administering Lactobacillus casei strain Shirota (LcS) on development NASH also investigated. Mice divided into three groups, given normal chow diet (NCD), MCD diet, or plus daily oral administration LcS for 6 wk. analyses groups revealed that lactic acid...
In Japan, no study has compared the perioperative outcomes observed between robot-assisted radical cystectomy (RARC) and open (ORC). This aimed at a prospective comparison of RARC ORC performed by single surgeon. Between 2008 2011, 26 bladder cancer patients underwent one surgeon, 11 robotically 15 procedure. We prospectively collected pathological data for these patients, retrospectively two different surgical procedures. The cohort had significant decrease in both estimated blood loss...
Glucose transporter 1 (GLUT1) is widely distributed throughout various tissues and contributes to insulin-independent basal glucose uptake. Using a split-ubiquitin membrane yeast two-hybrid system, we newly identified 4F2 heavy chain (4F2hc) as protein interacting with GLUT1. Though 4F2hc reportedly forms heterodimeric complexes between amino acid transporters, such LAT1 LAT2, regulates uptake, investigated the effects of on GLUT1 expression associated First, FLAG-tagged hemagglutinin-tagged...
Nonalcoholic steatohepatitis (NASH) is a disorder characterized by simultaneous fat accumulation and chronic inflammation in the liver. In this study, Pin1 expression was revealed to be markedly increased livers of mice with methionine choline-deficient (MCD) diet-induced NASH, rodent model NASH. addition, KO were highly resistant MCD-induced based on series data showing accumulation, inflammation, fibrosis terms Pin1-induced it that levels peroxisome proliferator-activated receptor α its...
The gut environment has been considered to play a role in the development of nonalcoholic steatohepatitis (NASH). α-glucosidase inhibitors (α-GIs) delay carbohydrate absorption and may change environment. We that protective effect α-GIs against NASH is related changes thus investigated effects miglitol, an α-GI, on Mice were divided into three groups fed normal chow diet (NCD), high-fat high-sucrose (HFHSD), or HFHSD plus 0.04% miglitol (HFHSD M) for 12 weeks. Insulin resistance developed...
Nonalcoholic steatohepatitis (NASH) is a disorder characterized by hepatic lipid accumulation followed the inflammation-induced death of hepatocytes and fibrosis. In this process, oxidative stress contributes to induction several inflammatory cytokines including TNF- α IL-1 β in macrophages, while, hepatocytes, NF- κ B reportedly induces expressions cell survival genes for protection from apoptosis. Recently, it was reported that new ubiquitin ligase complex termed linear chain assembly...
The severity of insulin resistance is higher in Japanese-American people with American lifestyles than native Japanese lifestyles. Recently, the role gut microbiota control host metabolic homeostasis and organ physiology has been recognized. In addition, alterations have suggested to contribute pathogenesis resistance. principle aim present study was evaluate impact a Westernized lifestyle on Japanese-Americans versus Japanese, its correlation resistance.A total 14 men living Hiroshima,...
Resistin-like molecule β (RELMβ) reportedly has multiple functions including local immune responses in the gut. In this study, we investigated possible contribution of RELMβ to non-alcoholic steatohepatitis (NASH) development. First, knock-out (KO) mice were shown be resistant methionine-choline deficient (MCD) diet-induced NASH Since it was newly revealed that Kupffer cells liver express and expression levels colon numbers RELMβ-positive both increased model, carried out further experiments...
Several lines of evidence have suggested a role gut microbiota in the etiology nonalcoholic steatohepatitis (NASH). NASH subjects reportedly showed prolonged orocecal transit time coexistent with small intestinal bacterial overgrowth. We considered possibility that enhanced gastrointestinal motility would influence and thus investigated effects gastroprokinetic agent mosapride citrate (MC) on development using methionine-choline deficient (MCD) diet-fed rodent model. Mice were divided into...
AMP-activated protein kinase (AMPK) plays an important role in insulin resistance, which is characterized by the impairment of insulin-Akt signaling pathway. However, time course decrease AMPK and Akt phosphorylation liver during development obesity resistance caused feeding a high fat diet (HFD) remains controversial. Moreover, it unclear whether pathways reversible when changing from HFD to standard (SD). Male ddY mice were fed SD or for 3 28 days, 14 followed days. We examined expression...
Abstract In this CyberKnife® dose verification study, we investigated the effectiveness of novel potential error (PE) concept when applied to determination a robust measurement point for targeting errors. PE was calculated by dividing differences between maximum increases and decreases in distributions original distribution after obtaining former shifting source-to-axis off-axis distances each beam ±1.0 mm. Thus, values heterogeneity were analyzed 48 patients who underwent CyberKnife...
Abstract The purpose of this study is to evaluate dose–volume histogram (DVH) predictors for the development chronic gastrointestinal (GI) complications in patients with cervical cancer who have undergone postoperative concurrent chemotherapy and whole-pelvic radiation therapy (WPRT). subjects were 135 had WPRT nedaplatin-based between 2000 2014. Associations selected DVH parameters incidence GI G3 or higher evaluated. Chronic severity occurred 18 (13%) patients. Patients significantly...
The acromegaly patient was diagnosed with Type 2 diabetes mellitus. His HbA1c 10.6% and fasting blood glucose (FBG) 15.3 mmol/l. We prescribed glibenclamide (10 mg/day), but his FBG remained high. At this stage, treatment short-acting insulin instigated at a dose of 20 U/day. However, the patient's level unsatisfactory. tried using pioglitazone.Pioglitazone 30 mg/day in combination insulin.The value decreased to 7.2 mmol/l 7.3%, respectively, within months discontinued. Pioglitazone alone...
The major errors in HDR brachytherapy are related to treatment distance, almost all of which caused by incorrect applicator information. aim this study is propose a quick pretreatment verification method evaluate channel length and dwell position with transparent applicator, which, addition, suitable as an education tool assist the understanding structure.A model was fabricated using three-dimensional printer resin. Its be replica real gynecological applicator. performed observing planned...
Objective— Hyperuricemia is common in patients with metabolic syndrome. We investigated the role of xanthine oxidoreductase (XOR) atherosclerosis development, and effects XOR inhibitor allopurinol on this process. Methods Results— Oral administration to ApoE knockout mice markedly ameliorated lipid accumulation calcification aorta aortic root. In addition, treatment or siRNA-mediated gene knockdown suppressed transformation J774.1 murine macrophage cells, treated acetylated LDL very low...