A5002638004- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Head and Neck Cancer Studies
- Sarcoma Diagnosis and Treatment
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Metastasis and carcinoma case studies
- Intraperitoneal and Appendiceal Malignancies
- Lung Cancer Research Studies
- Maternal and fetal healthcare
- Pregnancy and preeclampsia studies
- Oral and Maxillofacial Pathology
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- Chromatin Remodeling and Cancer
- Synthesis and Reactivity of Sulfur-Containing Compounds
University of Occupational and Environmental Health Japan
2018-2025
Osaka University
2014-2023
Kyushu University
2023
Nihon University
2023
Tohoku University
2023
Keio University
2023
Yamagata University Hospital
2023
Asana Biosciences (United States)
2023
Soka University
2013-2017
Tokai University
1986-2016
Fas ligand (FasL) is a type II integral membrane protein homologous with tumor necrosis factor (TNF). Recent studies indicate that TNF processed to yield the soluble cytokine by metalloproteinases at cell surface of activated macrophages and T cells. In present study, we investigated whether FasL also released metalloproteinases. Treatment hydroxamic acid inhibitors matrix specifically led accumulation membrane-type (p40) on human cDNA transfectants cells, as estimated immunofluorescence...
A prostate-specific gene, PCGEM1 , was identified by differential display analysis of paired normal and prostate cancer tissues. Multiple tissue Northern blot revealed that expressed exclusively in human tissue. Analysis expression matched primary tumor specimens tumor-associated overexpression 84% patients with situ hybridization assay 56% reverse transcription–PCR assay. Among various cell lines analyzed, detected only the androgen receptor-positive line LNCaP. Extensive DNA sequence cDNA...
Keratinocyte proliferation and migration are essential to cutaneous wound healing are, in part, mediated an autocrine fashion by epidermal growth factor receptor (EGFR)–ligand interactions. EGFR ligands initially synthesized as membrane-anchored forms, but can be processed shed soluble forms. We provide evidence here that stimuli induce keratinocyte shedding of vitro, particularly the ligand heparin-binding EGF-like (HB-EGF). The resulting stimulated transient activation EGFR. OSU8-1,...
The anti-proliferative activities of all twenty-five targeted kinase inhibitor drugs that are in clinical use were measured two large assay panels: (1) a panel proliferation assays forty-four human cancer cell lines from diverse tumour tissue origins; and (2) more than 300 enzyme activity assays. This study provides head-on comparison (status Nov. 2013), for six these drugs, the first kinome profiling data public domain. Correlation drug with gene mutations revealed novel sensitivity...
We examined lymph node metastasis clinicopathologically in 236 cases of superficial cancer (T1, Tis) the thoracic esophagus surgically resected at our department without adjuvant treatment. Mucosal was observed 112 (47%) and submucosal 124 (53%). Lymph present 3% mucosal 41% cases. By recent pathologic subclassification extent cancerous invasion esophageal cancer, were each divided into three subtypes according to invasion, i.e. m1, m2, m3, sm1, sm2 sm3 cancers. There no case m1 m2 cases,...
The metanephric kidney develops from interactions between the epithelial ureteric bud and adjacent mesenchyme, which is induced by to form epithelia of nephron. We have found that leukemia inhibitory factor (LIF) transforming growth beta 2 (TGF 2) are secreted inductive rat cells cooperate enhance accelerate renal tubule formation in uninduced mesenchymal explants. LIF alone or TGF with fibroblast numerous tubules isolated mesenchymes over an 8 day period, while (in combination) all three...
Abstract IL-18 has been shown to be a strong cofactor for Th1 T cell development. However, we previously demonstrated that when was combined with IL-2, there synergistic induction of Th2 cytokine, IL-13, in both and NK cells. More recently, other groups have reported can potentially induce IgE, IgG1, cytokine production murine experimental models. Here, report on the generation IL-18-transgenic (Tg) mice which mature mouse cDNA expressed. CD8+CD44high cells macrophages were increased, but B...
Squamous cell carcinoma (SCC) accounts for approximately 95% of the malignant tumors vaginal vulva and is mostly found in elderly women. The future numbers patients with vulvar SCC expected to rise, mainly because proportional increase average age general population. Two different pathways have been put forth. first pathway triggered by infection a high-risk-type Human Papillomavirus (HPV). Integration HPV DNA into host genome leads development typical intraepithelial neoplasia (VIN),...
Tumor stroma drives the growth and progression of cancers. A heparin-binding epidermal factor-like factor, HB-EGF, is an EGF receptor ligand that stimulates cell in autocrine or paracrine fashion. While elevated expression HB-EGF cancer cells its contribution to tumor are well documented, effects have not been clarified. Here, we show expressed stromal fibroblasts where it promotes proliferation. In uterine cervical cancers, was detected immunohistochemically proximal epithelium....
We demonstrate high-efficiency excitonic emission with deep-ultraviolet (DUV) light of 235 nm at room temperature for a (111)-oriented diamond p-i-n junction light-emitting diode (LED) by introducing thick i-layer. Significant enhancement in efficiency over 500 times was observed LED increasing the i-layer thickness from 0.1 to 14 μm. Maximum output power and external quantum without any specific device structure were mW 0.006%, respectively, under pulsed-current injection. also...
We have investigated the association between polymorphisms of drug-metabolizing enzymes and susceptibility to head-and-neck squamous-cell carcinoma (HNSCC). PCR-based analysis was performed on 145 Japanese patients 164 healthy controls determine genotypes in CYP1A1, CYP2E1, GSTM1, GSTP1, NAT2. Patients were compared by multivariate analysis. The CYP1A1 Val/Val genotype seen more frequently than [odds ratio (OR) 4.1, p = 0.038). frequency slow plus intermediate NAT2 also higher (OR 2.0,...
Abstract The role of the replication error‐positive (RER + ) phenotype in development specific subtypes sporadic ovarian carcinomas was examined by screening for presence microsatellite instability (MI) 47 tumors. overall frequency MI 17% only. However, occurred 50% endometrioid‐type tumors, which significantly more often than all other histological sub‐types combined (8%). Five 8 RER tumors exhibited most marked type I instability, possibly representing a different mechanism remaining 2...
A series of phosphonamide-based hydroxamate derivatives were synthesized, and the inhibitory activities evaluated against various metalloproteinases in order to clarify its selectivity profile. Among four diastereomeric isomers resulting from chirality at C-3 P atoms, compound with a (R,R)-configuration both position phosphorus atom was found be potently active, while other almost inactive. number (R,R)-compounds synthesized here exhibited broad spectrum nanomolar K(i) values MMP-1, -3, -9,...
To determine the potential role of PTEN in process endometrial carcinogenesis, we examined a series carcinoma and hyperplasia uterine corpus for presence mutation. The entire coding region gene was screened mutations by single-strand conformation polymorphism analysis, were confirmed sequencing. We detected 14 57 carcinomas (13 50 endometrioid adenocarcinomas 1 7 nonendometrioid adenocarcinomas) 73 hyperplasias (1 24 simple without atypia, none 16 complex 6 33 with atypia). Most (88%)...
LAMP3 (DC-LAMP, TSC403, CD208) was originally isolated as a gene specifically expressed in lung tissues. is located on chromosome 3q segment that frequently amplified some human cancers, including uterine cervical cancer. Because two other members of the LAMP family lysosomal membrane glycoproteins, LAMP1 and LAMP2, were previously implicated potentially modulating interaction vascular endothelial cancer cells, we hypothesized might also play an important part metastasis. To clarify...