A5055298713- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Sarcoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Cervical Cancer and HPV Research
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Crystallization and Solubility Studies
- Reproductive System and Pregnancy
- Renal Diseases and Glomerulopathies
- Renal cell carcinoma treatment
- Venous Thromboembolism Diagnosis and Management
- X-ray Diffraction in Crystallography
- Galectins and Cancer Biology
- Estrogen and related hormone effects
- Systemic Lupus Erythematosus Research
- Advanced Proteomics Techniques and Applications
- Gynecological conditions and treatments
- Chromatin Remodeling and Cancer
- Intraperitoneal and Appendiceal Malignancies
- Ectopic Pregnancy Diagnosis and Management
- Crystallography and molecular interactions
- Genomics and Phylogenetic Studies
Tokyo University of Agriculture
2025
Tokai University
2012-2021
Hokkaido Chitose College of Rehabilitation
2015-2017
Shonan Oiso Hospital
2009
To examine the survival outcomes in women with endometrial cancer who were taking low-dose aspirin (81-100 mg/d).A multicenter retrospective study was conducted examining patients stage I-IV underwent hysterectomy-based surgical staging between January 2000 and December 2013 (N=1,687). Patient demographics, medical comorbidities, medication types, tumor characteristics, treatment patterns correlated to outcomes. A Cox proportional hazard regression model used estimate adjusted ratio for...
Ovarian cancer is a leading cause of deaths among gynecological cancers, and method to detect early-stage epithelial ovarian (EOC) urgently needed. We aimed develop an artificial intelligence (AI)-based comprehensive serum glycopeptide spectra analysis (CSGSA-AI) in combination with convolutional neural network (CNN) aberrant glycans samples patients EOC. converted expression patterns into two-dimensional (2D) barcodes let CNN learn distinguish between EOC non-EOC. was trained using 60%...
We evaluated the clinical role of combination positron emission tomography (PET) with F-18 fluorodeoxyglucose (FDG) and tumor marker CA125, in detection recurrence after initial therapy for epithelial ovarian cancer. The indication is cases that cannot be confirmed by conventional imaging modalities. Ninety patients underwent PET computed tomography, including measurement specific markers. FDG-PET 46 (51%), recurrent site was alone 17 (37%). had high sensitivity detecting both...
Objective:The Japan Society of Gynecologic Oncology (JSGO) published the first practice guideline for endometrial cancer in 2006.The JSGO evaluation committee assessed effect this introduction on clinical and patient outcome using data provided by Obstetrics Gynecology (JSOG) registration system.Methods: Data patients with registered between 2000 2012 were analyzed, epidemiological trends assessed.The influence survival was determined analyzing 2004 2009 competing risk model.Results: In...
Objective:The Japan Society of Gynecologic Oncology (JSGO) initiated a nation-wide training system for the education and certification gynecologic oncologists in 2005.To assess impact quality JSGO-accredited institutions, JSGO undertook an analysis Uterine Cervical Cancer Registry Obstetrics Gynecology (JSOG) to determine effectiveness institutions on treatment survival women with cervical cancer.Methods: The 119 125 non-JSGO-accredited cancer were compared by analyzing tumor...
We evaluated the usefulness of whole-body positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG-PET) for detection recurrence in follow-up patients after primary treatment uterine sarcoma. Eight with pathologically proven sarcoma underwent FDG-PET, computed (CT), and ultrasonography (US). Final diagnoses were established five cases (three carcinosarcomas two leiomyosarcomas). PET revealed recurrent sites intraperitoneum, liver, lung, bone, retroperitoneal lymph nodes....
Problem: Preconception high peripheral natural killer (NK) cell activity in women with recurrent spontaneous abortion can predict subsequent miscarriages. We have examined prospectively, for the first time, pregnancy rate patients unexplained infertility by measuring NK activity. Method of study: tested 94 infertile who despite treatment were unable to conceive 6 or more months (mean; 2.4 years). Peripheral was measured a chromium‐51 release cytotoxicity assay. Women followed 2 years and...
Leiomyomas of uterus are common disease in gynecology. It is important to differentiate leiomyoma from leiomyosarcoma at the decision treatment methods, especially case conservative for uterine leiomyoma. But exact diagnosis benign often difficult due degeneration myoma by imaging modalities including magnetic resonance imaging. Recently, whole-body positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) has been used a malignant tumors. There growing body evidence use FDG...
Patients undergoing in vitro fertilization and embryo transfer (IVF-ET) failures show an increased incidence of antiphospholipid antibodies (aPL) their blood. The physiological manifestations aPL this patient group are nonetheless controversial. Pathological effects on embryos have been documented. We questioned whether if found follicular fluids (FFs) could result embryonic damage.Blood from 44 patients with three or more IVF-ET were tested by enzyme-linked immunosorbent assays (ELISA) for...
To examine survival of women with stage IV uterine carcinosarcoma (UCS) who received neoadjuvant chemotherapy followed by hysterectomy.This is a nested case-control study within retrospective cohort 1192 UCS cases. Women hysterectomy based-surgery for (n = 26) were compared to those had primary hysterectomy-based surgery without 120). Progression-free (PFS) and cause-specific (CSS) examined.The most common regimen was carboplatin/paclitaxel (53.8%). Median number cycles 4. PFS similar...
Objectives: To conduct a comprehensive glycopeptide spectra analysis of serum between cancer and non-cancer patients to identify early biomarkers epithelial ovarian (EOC). Methods: Approximately 30,000 peaks were detected from the digested glycoproteins 39 EOC (23 early-stage, 16 advanced-stage) 45 (27 leiomyoma cyst cases, 18 endometrioma cases) by liquid chromatography mass spectrometry (LC–MS). The differential peak analyzed distinguish groups employing multivariate including principal...
Problem: The presence of IgG anti‐annexin A5 (IgGαA5) and/or antiphospholipid antibodies (aPL) are risk factors associated with recurrent spontaneous abortion. Problems whether IgA (IgAαA5) is pathogenic, and how IgGαA5 works. Method study: Blood samples from 238 patients early abortion, 48 in vitro fertilization‐embryo transfer failure, 179 non‐pregnant women 120 pregnant controls were tested for IgAαA5 by enzyme‐linked immunosorbent assay. We also determined if appeared coincident aPL....
Objective Chemotherapy is a standard adjuvant treatment after primary surgery for endometrial cancer in Japan. We aimed to characterize the clinical features of recurrent (REC) patients Materials and Methods retrospectively reviewed medical records 112 REC who were primarily treated at 1 3 university hospitals Japan from 2005 2012. analyzed overall survival since first recurrence (R-OS) accordance with several factors. Results Median patient age was 64 years. The median follow-up period 48...