Melissa Moffitt
A5017596910- Ovarian cancer diagnosis and treatment
- RNA modifications and cancer
- Uterine Myomas and Treatments
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cervical Cancer and HPV Research
- COVID-19 and healthcare impacts
- Epigenetics and DNA Methylation
- Gestational Trophoblastic Disease Studies
- DNA Repair Mechanisms
- Endometrial and Cervical Cancer Treatments
- Polyomavirus and related diseases
- Immunotherapy and Immune Responses
- Endometriosis Research and Treatment
- Cancer Genomics and Diagnostics
- COVID-19 Clinical Research Studies
- BRCA gene mutations in cancer
- PARP inhibition in cancer therapy
- Prenatal Screening and Diagnostics
- Infection Control and Ventilation
- Maternal and fetal healthcare
- Reproductive Biology and Fertility
- Urinary and Genital Oncology Studies
- Ectopic Pregnancy Diagnosis and Management
- Anatomy and Medical Technology
Roswell Park Comprehensive Cancer Center
2020-2022
Oregon Health & Science University
2012-2021
Gynecologic Oncology Group
2016
University of Southern California
2010-2011
Abstract STUDY QUESTION Can group culture with stage-specific anti-Müllerian hormone (AMH) modulation support human follicular development and oocyte maturation in vitro? SUMMARY ANSWER In the presence of FSH, AMH supplementation at secondary-to-early antral stage followed by depletion promotes coordinated growth function follicles during culture, thereby yielding mature oocytes. WHAT IS KNOWN ALREADY Stage-specific in-vitro nonhuman primate follicles. The method supports follicle from...
Background The identification of sensitive biomarkers for the detection ovarian cancer is high clinical relevance early and/or monitoring disease recurrence. We developed a systematic multi-step biomarker discovery and verification strategy to identify candidate DNA methylation markers blood-based cancer. Methodology/Principal Findings used Illumina Infinium platform analyze status 27,578 CpG sites in 41 tumors. employed marker selection that emphasized sensitivity by requiring consistency...
// Jennifer B. Permuth 1 , Brett Reid Madalene Earp 2 Y. Ann Chen 3 Alvaro N.A. Monteiro Zhihua AOCS Study Group 4,5 Georgia Chenevix-Trench 4 Peter A. Fasching 6,7 Matthias W. Beckmann 7 Diether Lambrechts 8,9 Adriaan Vanderstichele 10 Els Van Niewenhuyse Ignace Vergote Mary Anne Rossing 11,12 Doherty 13 Jenny Chang-Claude 14,15 Kirsten Moysich 16 Kunle Odunsi 17 Marc T. Goodman 18,19 Yurii Shvetsov 20 Lynne R. Wilkens Pamela J. Thompson Thilo Dörk 21 Natalia Bogdanova 22 Ralf Butzow 23...
Abstract Background: Many loci have been found to be associated with risk of epithelial ovarian cancer (EOC). However, although there is considerable variation in progression-free survival (PFS), no outcome at genome-wide levels significance. Methods: We carried out a association study (GWAS) PFS 2,352 women EOC who had undergone cytoreductive surgery and standard carboplatin/paclitaxel chemotherapy. Results: seven SNPs 12q24.33 (P < 5 × 10–8), the top SNP being rs10794418 (HR = 1.24;...
// Dylan M. Glubb 1 , Sharon E. Johnatty Michael C.J. Quinn Tracy A. O'Mara Jonathan P. Tyrer 2 Bo Gao 3,4 Peter Fasching 5,6 Matthias W. Beckmann 6 Diether Lambrechts 7,8 Ignace Vergote 9 Digna R. Velez Edwards 10 Alicia Beeghly-Fadiel 11 Javier Benitez 12 Maria J. Garcia Marc T. Goodman 13,14 Pamela Thompson Thilo Dörk 15 Dürst 16 Francesmary Modungo 17,18,19 Kirsten Moysich 20 Florian Heitz 21,22 Andreas du Bois Jacobus Pfisterer 23 Hillemanns 24 On behalf of the AGO Study Group, Beth Y....
Rare variants in MAGEC3 are associated with BRCA negative, early-onset ovarian cancers. Given this association, we evaluated the impact of protein expression on prognosis and transcription. We quantified normal tumor via immunohistochemistry n = 394 advanced cancers, assessed correlation these values clinicopathologic immunological features modeled survival using univariate multivariate models. To extend results, 180 cancers used matching RNA sequencing data to determine MAGEC3-associated...
Abstract An association between genetic variants in the vitamin D receptor ( VDR ) gene and epithelial ovarian cancer (EOC) was previously reported women of African ancestry (AA). We sought to examine associations additional genes from biosynthesis pathway targets EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5 , CYP2R1 CYP27B1 CYP24A1 CYP11A1 GC ). Genotyping performed using custom‐designed 533,631 SNP Illumina OncoArray with imputation 1,000 Genomes Phase 3 v5 reference set 755 EOC cases, including...
•Primary mediastinal choriocarcinoma is rare, especially in female patients.•Genomic losses predominated our case, which has not been previously reported.•This tumor lacked human chorionic gonadotropin and required histologic diagnosis.
Background: Fanconi Anemia is a rare condition that carries an increased risk of squamous cell carcinoma the head, neck and cervix due to mutations in DNA repair pathways. These same may also be associated with intrinsic treatment resistance (FANCD2) hypersensitivity (FANCA). Case: A 22-year-old woman history anemia who presented rapid progression cervix. She developed aplastic during chemoradiation was subsequently diagnosed Anemia. Conclusion: Rare conditions such as should considered when...
ABSTRACT Rare variants in MAGEC3 , members of the melanoma antigen gene family, are associated with BRCA-independent early onset ovarian cancers, while somatic mutations this have been kidney cancers. In report, we quantified normal and tumor protein expression via immunohistochemistry N=394 cancers N=220 renal cell carcinomas. levels fell into two categories – loss characterized by equivalent to tissue or significantly lower than tissue, respectively. Interestingly, cases demonstrated...