Argyrios Ziogas
A5070123199- Ovarian cancer diagnosis and treatment
- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Cancer Risks and Factors
- Genetic factors in colorectal cancer
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Economic and Financial Impacts of Cancer
- Cancer Genomics and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Nutritional Studies and Diet
- Epigenetics and DNA Methylation
- Multiple and Secondary Primary Cancers
- Lung Cancer Treatments and Mutations
- Nutrition, Genetics, and Disease
- Cervical Cancer and HPV Research
- Lung Cancer Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Molecular Biology Techniques and Applications
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
University of California, Irvine
2016-2025
UC Irvine Health
2023-2024
Eisai (Japan)
2023
Cancer Research UK
2009-2023
Jazz Pharmaceuticals (United States)
2023
Karyopharm Therapeutics (United States)
2023
Bristol-Myers Squibb (Germany)
2023
AstraZeneca (Canada)
2023
Deciphera Pharmaceuticals (United States)
2023
ImmunoGen (United States)
2023
Endometriosis is a risk factor for epithelial ovarian cancer; however, whether this extends to all invasive histological subtypes or borderline tumours not clear. We undertook an international collaborative study assess the association between endometriosis and of cancer.
Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone (PR) expression status of the tumors.
Population-based estimates of the risk breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for assessment and management women inherited variants.
Approximately 60% of families that meet the Amsterdam-I criteria (AC-I) for hereditary nonpolyposis colorectal cancer (HNPCC) have a abnormality in DNA mismatch repair (MMR) gene. Cancer incidence AC-I with MMR gene mutations is reported to be very high, but individuals no evidence an defect unknown.To determine if risks apparent deficiency are different from abnormalities.Identification (1997-2001) 161 pedigrees multiple population- and clinic-based sources North America Germany, grouped...
Data for multiple common susceptibility alleles breast cancer may be combined to identify women at different levels of risk. Such stratification could guide preventive and screening strategies. However, empirical evidence genetic risk is lacking. We investigated the value using 77 cancer-associated single nucleotide polymorphisms (SNPs) stratification, in a study 33 673 cases 381 control European origin. tested all possible pair-wise multiplicative interactions constructed 77-SNP polygenic...
Importance: Breast cancer in women between the ages of 15 and 39 years (adolescents young adults [AYAs]) constitutes 5% to 6% all breast cases United States.Breast AYA has a worse prognosis than older women.Five-year survival rates are lowest for women, only few studies have examined impact delay treatment, race/ ethnicity, other socioeconomic factors on women.Objective: To examine treatment time (TDT), race/ethnicity, status, insurance stage, age from among women.Design, Setting,...
Whilst previous studies have reported that higher BMI increases a woman's risk of developing ovarian cancer, associations for the different histological subtypes not been well defined. As prevalence obesity has increased dramatically, and classification histology improved in last decade, we sought to examine association pooled analysis recent participating Ovarian Cancer Association Consortium. We evaluated between (recent, maximum young adulthood) cancer using original data from 15...
In Brief OBJECTIVES: To validate National Comprehensive Cancer Network ovarian cancer guideline adherence as a quality process measure associated with improved survival, and to identify structural health care characteristics predictive of care. METHODS: Consecutive patients epithelial diagnosed between 1 January 1999 31 December 2006 were identified from the California Registry. Adherence was defined by stage-appropriate surgical procedures recommended chemotherapy. Multivariable logistic...
The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some these are with breast risk as high those rare BRCA2 mutations. We aimed the relative risks specific variants via a multicentre case-control study.
Abstract Breast, ovarian, and prostate cancers are hormone-related may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these totaling 112,349 cases 116,421 controls of European ancestry, all together in pairs, identified at P < 10−8 seven new cross-cancer loci: three associated with susceptibility to (rs17041869/2q13/BCL2L11;...
PURPOSE To estimate the risk of contralateral breast cancer (CBC) among women with germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2. METHODS The study population included 15,104 prospectively followed within CARRIERS treated ipsilateral surgery for invasive cancer. CBC was estimated PV carriers each gene compared without PVs a multivariate proportional hazard regression analysis accounting competing death adjusting patient tumor characteristics. primary analyses...
The etiology of familial breast cancer is complex and involves genetic environmental factors such as hormonal lifestyle factors. Understanding aggregation a key to understanding the causes facilitating development effective prevention therapy. To address urgent research questions expedite translation results clinical setting, National Cancer Institute (USA) supported in 1995 establishment novel infrastructure, Breast Family Registry, collaboration six academic institutions their medical...
No AccessJournal of Urology1 Apr 1993The Rationale for EN Bloc Pelvic Lymph Node Dissection Bladder Cancer Patients with Nodal Metastases: Long-Term Results Seth P. Lerner, Donald G. Skinner, Gary Lieskovsky, Stuart D. Boyd, Susan L. Groshen, Argyrios Ziogas, Eila Peter Nichols, and Barbara Hopwood LernerSeth Lerner , SkinnerDonald Skinner LieskovskyGary Lieskovsky BoydStuart Boyd GroshenSusan Groshen ZiogasArgyrios Ziogas SkinnerEila NicholsPeter Nichols HopwoodBarbara View All Author...
Abstract BACKGROUND. Platinum‐based adjuvant chemotherapy in randomized trials has failed to provide a survival benefit patients with resected stage I nonsmall cell lung cancer (NSCLC). Using data from the California Cancer Registry (CCR), we explored factors that had detrimental effects on NSCLC identify subset of at high risk for disease recurrence and subsequent mortality. METHODS. Between 1989 2003, 19,702 incident cases CCR were identified subgrouped into IA IB disease. Patient...
Abstract Background: Poor survival among colorectal cancer (CRC) cases has been associated with African-American race and low socioeconomic status (SES). However, it is not known whether the observed poor of CRC due to SES itself and/or treatment disparities. We set out determine this using data from large, population-based California Cancer Registry database. Methods: A case-only analysis was conducted including all age groups 1994 2003, descriptive relevant clinical variables, race, SES....
We tested the hypotheses that CHEK2*1100delC heterozygosity is associated with increased risk of early death, breast cancer-specific and a second cancer in women first cancer.From 22 studies participating Breast Cancer Association Consortium, 25,571 white invasive were genotyped for observed up to 20 years (median, 6.6 years). examined death by estrogen receptor status after prospective studies.CHEK2*1100delC was found 459 patients (1.8%). In receptor-positive cancer, multifactorially...
Purpose Although uncommon, melanoma is associated with poor survival characteristics among African Americans and Hispanics compared non-Hispanic whites (NHWs). Low socioeconomic status (SES) also patients melanoma, but it not known whether this because of SES itself or treatment disparities. We set out to determine by using the large, population-based California Cancer Registry (CCR) database as a model. Patients Methods conducted case-only analysis CCR data (1993 2003), including...
CHEK2*1100delC is a well-established breast cancer risk variant that most prevalent in European populations; however, there are limited data on of by age and tumor subtype, which limits its usefulness prediction. We aimed to generate subtype- age-specific estimates using from the Breast Cancer Association Consortium, including 44,777 patients with 42,997 controls 33 studies genotyped for CHEK2*1100delC.