A5033145217- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Lung Cancer Treatments and Mutations
- Genomics and Rare Diseases
- Computational Drug Discovery Methods
- Nutrition, Genetics, and Disease
- Health Systems, Economic Evaluations, Quality of Life
- Protein Degradation and Inhibitors
- Gene expression and cancer classification
- Diabetes Treatment and Management
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- Diabetes Management and Research
- Pancreatic and Hepatic Oncology Research
- Statistical Methods in Clinical Trials
- Gut microbiota and health
- HER2/EGFR in Cancer Research
- Sarcoma Diagnosis and Treatment
- Genetics, Bioinformatics, and Biomedical Research
- Epigenetics and DNA Methylation
- PARP inhibition in cancer therapy
- Molecular Biology Techniques and Applications
- Breast Cancer Treatment Studies
Chicago Department of Public Health
2022-2025
University of Chicago
2022-2025
Mayo Clinic in Florida
2017-2024
University of Chicago Medical Center
2024
WinnMed
2021-2023
Center for Cancer Research
2013-2023
Mayo Clinic
2018-2023
University of Minnesota Rochester
2023
Mayo Clinic in Arizona
2016-2022
Cancer Clinic
2022
Atopic dermatitis (AD) has long been associated with Staphylococcus aureus skin colonization or infection and is typically managed regimens that include antimicrobial therapies. However, the role of microbial communities in pathogenesis AD incompletely characterized. To assess relationship between microbiota disease progression, 16S ribosomal RNA bacterial gene sequencing was performed on DNA obtained directly from serial sampling children AD. The composition analyzed during states to...
When trying to learn a model for the prediction of an outcome given set covariates, statistician has many estimation procedures in their toolbox. A few examples these candidate learners are: least squares, angle regression, random forests, and spline regression. Previous articles (van der Laan Dudoit (2003); van et al. (2006); Sinisi (2007)) theoretically validated use cross validation select optimal learner among learners. Motivated by this validation, we propose new method creating...
Population-based estimates of the risk breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for assessment and management women inherited variants.
Germline pathogenic variants in BRCA1 and BRCA2 predispose to an increased lifetime risk of breast cancer. However, the relevance germline other genes from multigene hereditary cancer testing panels is not well defined.To determine risks associated with predisposition genes.A study population 65 057 patients receiving genetic panels. Associations between non-BRCA1 non-BRCA2 were estimated a case-control analysis Exome Aggregation Consortium reference controls. The women underwent March 15,...
Individuals genetically predisposed to pancreatic cancer may benefit from early detection. Genes that predispose and the risks of associated with mutations in these genes are not well defined.To determine whether inherited germline predisposition increased cancer.Case-control analysis identify genes; longitudinal patients for prognosis. The study included 3030 adults diagnosed as having enrolled a Mayo Clinic registry between October 12, 2000, March 31, 2016, last follow-up on June 22, 2017....
Characterization of the topographical and temporal diversity microbial collective (microbiome) hosted by healthy human skin established a reference for studying disease-causing microbiomes. Physiologic changes occur in as humans mature from infancy to adulthood. Thus, characterizations adult microbiomes might have limitations when considering pediatric disorders such atopic dermatitis (AD) or issues sites carriage. The objective this study was determine if communities at several body...
Abstract Background Lung cancer is the leading diagnosis worldwide and number one cause of deaths. Exposure to cigarette smoke, primary risk factor in lung cancer, reduces epithelial barrier integrity increases susceptibility infections. Herein, we hypothesize that somatic mutations together with smoke generate a dysbiotic microbiota associated carcinogenesis. Using tissue from 33 controls 143 cases, conduct 16S ribosomal RNA (rRNA) bacterial gene sequencing, RNA-sequencing data cases The...
A well-characterized library of experimental kinase inhibitors provides leads for targeting the untargeted kinome. Despite success protein as approved therapeutics, drug discovery has focused on a small subset targets. Here we provide thorough characterization Published Kinase Inhibitor Set (PKIS), set 367 small-molecule ATP-competitive that was recently made freely available with aim expanding research in this field and an experiment open-source target validation. We screen activity assays...
Abstract To date, over 100 small-molecule oncology drugs have been approved by the FDA. Because of inherent heterogeneity tumors, these small molecules are often administered in combination to prevent emergence resistant cell subpopulations. Therefore, new strategies overcome drug resistance patients with advanced cancer needed. In this study, we performed a systematic evaluation therapeutic activity 5,000 pairs FDA-approved against panel 60 well-characterized human tumor lines (NCI-60)...
Abstract The NCI-60 cell lines are the most frequently studied human tumor in cancer research. This panel has generated extensive pharmacology database worldwide. In addition, these have been intensely investigated, providing a unique platform for hypothesis-driven research focused on enhancing our understanding of biology. Here, we report comprehensive analysis coding variants identified by whole exome sequencing, list possible specific community. Furthermore, identify pharmacogenomic...
Germline genetic testing with hereditary cancer gene panels can identify women at increased risk of breast cancer. However, those triple-negative (estrogen receptor–negative, progesterone human epidermal growth factor receptor–negative) (TNBC) cannot be identified because predisposition genes for TNBC, other than BRCA1, have not been established. The aim this study was to define the panel associated TNBC. Multigene 21 in 8753 TNBC patients performed by a clinical laboratory, and 17 2148...
Alveolar soft part sarcoma (ASPS) is a rare, highly vascular tumor, for which no effective standard systemic treatment exists patients with unresectable disease. Cediranib potent, oral small-molecule inhibitor of all three endothelial growth factor receptors (VEGFRs).
PurposeDespite the rapid uptake of multigene panel testing (MGPT) for hereditary cancer predisposition, there is limited guidance surrounding indications and genes to include.MethodsTo inform clinical approach MGPT, we comprehensively evaluated 32 predisposition by assessing phenotype-specific pathogenic variant (PV) frequencies, risk associations, performance genetic criteria in a cohort 165,000 patients referred MGPT.ResultsWe identified extensive heterogeneity types commonly germline...
PURPOSE To estimate the risk of contralateral breast cancer (CBC) among women with germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2. METHODS The study population included 15,104 prospectively followed within CARRIERS treated ipsilateral surgery for invasive cancer. CBC was estimated PV carriers each gene compared without PVs a multivariate proportional hazard regression analysis accounting competing death adjusting patient tumor characteristics. primary analyses...
Importance The increasing use of glucagon-like peptide-1 receptor agonists (GLP-1RA) demands a better understanding their association with thyroid cancer. Objective To estimate the risk incident cancer among adults type 2 diabetes being treated GLP-1RA vs other common glucose-lowering medications. Design, Setting, and Participants This was prespecified secondary analysis target trial emulation comparative effectiveness study using claims data for enrollees in commercial, Medicare Advantage,...
Many alternative data-adaptive algorithms can be used to learn a predictor based on observed data. Examples of such learners include decision trees, neural networks, support vector regression, least angle logic and the Deletion/Substitution/Addition algorithm. The optimal learner for prediction will vary depending underlying data-generating distribution. In this article we introduce "super learner", algorithm that applies any set candidate uses cross-validation select between them. Theory...
Purpose Desmoid tumors (aggressive fibromatosis) arise from connective tissue cells or fibroblasts. In general, they are slow growing and do not metastasize; however, locally aggressive desmoid can cause severe morbidity loss of function. Disease recurrence after surgery and/or radiation diagnosis multifocal highlight the need to develop effective systemic treatments for this disease. study, we evaluate objective response rate therapy with γ-secretase inhibitor PF-03084014 in patients...
Background: Small cell lung carcinoma (SCLC) is an aggressive, recalcitrant cancer, often metastatic at diagnosis and unresponsive to chemotherapy upon recurrence, thus it challenging treat. Methods: Sixty-three human SCLC lines three NSCLC were screened for response 103 US Food Drug Administration–approved oncology agents 423 investigational agents. The library was a diverse set of small molecules that included multiple compounds targeting the same molecular entity. in triplicate nine...
Background Emollients are a mainstay of treatment in atopic dermatitis (AD), disease distinguished by skin bacterial dysbiosis. However, changes microbiota when emollients used as potential AD preventative measure infants remain incompletely characterized. Results We compared barrier parameters, development, and 16S ribosomal RNA gene sequences cheek, dorsal volar forearm samples from 6-month-old with family history atopy randomized to receive (n = 11) or no (controls, n 12). The emollient...
Obesity is accompanied by numerous systemic and tissue-specific derangements, including inflammation, insulin resistance, mitochondrial abnormalities in skeletal muscle. Despite growing recognition that adipose tissue dysfunction plays a role obesity-related disorders, the relationship between inflammation other pathological features of obesity not well-understood. We assessed macrophage populations measured expression inflammatory cytokines abdominal biopsies 39 nondiabetic adults across...