Nicole L. Larson
A5042423377- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Cancer survivorship and care
- Estrogen and related hormone effects
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
- Breast Cancer Treatment Studies
- Hair Growth and Disorders
- Reproductive Biology and Fertility
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Risks and Factors
- Genetic Associations and Epidemiology
- Breast Implant and Reconstruction
- Cancer Genomics and Diagnostics
- Economic and Financial Impacts of Cancer
- Vaccine Coverage and Hesitancy
- Nutrition, Genetics, and Disease
- Patient-Provider Communication in Healthcare
- Music Therapy and Health
- Ethics and Legal Issues in Pediatric Healthcare
- Nonmelanoma Skin Cancer Studies
- Lymphatic System and Diseases
- Brain Metastases and Treatment
- Biomedical Ethics and Regulation
- Sex and Gender in Healthcare
Mayo Clinic in Florida
2020-2025
Mayo Clinic in Arizona
2021-2024
Mayo Clinic
2021-2024
WinnMed
2021-2024
Research Advocacy Network
2023
Department of Medical Sciences
2021
PURPOSE To estimate the risk of contralateral breast cancer (CBC) among women with germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2. METHODS The study population included 15,104 prospectively followed within CARRIERS treated ipsilateral surgery for invasive cancer. CBC was estimated PV carriers each gene compared without PVs a multivariate proportional hazard regression analysis accounting competing death adjusting patient tumor characteristics. primary analyses...
PURPOSE The prevalence of germline pathogenic variants (PVs) in established breast cancer predisposition genes women the general population over age 65 years is not well-defined. However, testing guidelines suggest that diagnosed with might have < 2.5% likelihood a PV high-penetrance gene. This study aimed to establish frequency PVs and remaining risks for each gene years. METHODS A total 26,707 from population-based studies (51.5% 48.5% unaffected) were tested Frequencies associations...
Abstract Survey data from the Mayo Clinic Breast Disease Registry were used to assess fertility counseling and preservation strategies in a modern cohort of young women with breast cancer. One hundred respondents identified who under age 50 at time cancer diagnosis expressed interest future childbearing near and/or 1 year later. Ninety-three percent 81 one survey recalled prior treatment. Most reported high level concern declared that this had impacted their treatment decisions, often...
Over 50% of households in the United States have at least one musician-many musicians are also breast cancer survivors. This group has not been well studied, and given level fine sensory-motor skill required for musicianship, we hypothesized that experience unique manifestations treatment toxicities. A nine-item Musical Toxicity Questionnaire (MTQ) was distributed to patients who had consented participate Mayo Clinic Breast Cancer Registry. The MTQ screened participants by asking if they...
The role of germline genetics in adjuvant aromatase inhibitor (AI) treatment efficacy ER-positive breast cancer is poorly understood. We employed a two-stage candidate gene approach to examine associations between survival endpoints and common variants 753 endocrine resistance-related genes. For discovery cohort, we screened the Breast Cancer Association Consortium database (n ≥ 90,000 cases) retrieved 2789 AI-treated patients. Cox model-based analysis revealed 125 associated with overall,...
PURPOSE To determine the contribution of germline pathogenic variants (PVs) in hereditary cancer testing panel genes to invasive lobular carcinoma (ILC) breast. MATERIALS AND METHODS The study included 2,999 women with ILC from a population-based cohort and 3,796 undergoing clinical multigene (clinical cohort). Frequencies PVs breast predisposition ( ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, PALB2, PTEN, RAD51C, RAD51D, TP53) were compared between unaffected female controls infiltrating...
Three-dimensional (3D) imaging is increasingly being incorporated into a variety of medical specialties: surgery and radiology but two prominent examples. Image-intensive disciplines, such as anatomic pathology (AP), represent excellent potential candidates for further exploration this innovative technology. Multiple use cases exist within AP, involving patient care, education, research. These broadly include direct utilization the 3D digital assets viewing on 2D screen, populating extended...
The aims of the Advocate-BREAST project are to study and improve breast cancer (BC) patient experience through education patient-centered research.
Abstract Background Genome-wide studies of gene–environment interactions (G×E) may identify variants associated with disease risk in conjunction lifestyle/environmental exposures. We conducted a genome-wide G×E analysis ~ 7.6 million common and seven factors for breast cancer overall estrogen receptor positive (ER +) cancer. Methods Analyses were using 72,285 cases 80,354 controls European ancestry from the Breast Cancer Association Consortium. Gene–environment evaluated standard...
Abstract Background Physical activity is associated with decreased breast cancer recurrence and mortality, as well fewer treatment-related symptoms. Nevertheless, most survivors do not meet physical guidelines. The purpose of this manuscript to characterize trends over time in survivors. Methods Mayo Clinic Breast Disease Registry participants received surveys at baseline 1 4 years after diagnosis; and/or metastatic disease were exclusion criteria. Participants considered be meeting...
Background: There are limited evidence-based data to guide treatment recommendations for breast cancer (BC) patients ≥ 80 years (P80+). Identifying and addressing unmet needs critical. Aims: Advocate-BREAST80+ compared the of P80+ vs. &lt; (P80-). Methods: In 12/2021, a REDCap survey was circulated electronically 6,918 persons enrolled in Mayo Clinic Breast Disease Registry. The asked about concerns satisfaction with multiple aspects BC care. Results: 2,437 participants responded (35 %...
A combination of genetic and functional approaches has identified three independent breast cancer risk loci at 2q35. recent fine-scale mapping analysis to refine these associations resulted in 1 (signal 1), 5 2), 42 3) credible causal variants loci. We used publicly available silico DNase I ChIP-seq data with vitro reporter gene CRISPR assays annotate signals 2 3. putative regulatory elements that enhanced cell-type-specific transcription from the IGFBP5 promoter both (30- 40-fold increased...
Objective: To better understand the characteristics associated with a participant's willingness to consent Mayo Clinic Biobank (MCB) and examine factors participate in follow-up studies embedded within MCB that require re-contact participant approval. Participants Methods: Consent rates were compared across patient demographics MCB. Rates of participation also request types. Results: Among 272,102 patients invited MCB, 48,314 (19%) consented three recruitment sites 90 days initial...
Use of menopausal hormone therapy (MHT) is associated with increased risk for breast cancer. However, the relevant mechanisms and its interaction genetic variants are not fully understood. We conducted a genome-wide analysis between MHT use cancer in 27,585 cases 34,785 controls from 26 observational studies. All women were post-menopausal European ancestry. Multivariable logistic regression models used to test multiplicative interactions current use. considered p-values < 5 × 10-8 as...
Abstract Background: Eyebrow and eyelash loss, known as madarosis, can occur secondary to breast cancer-directed therapy. However, the incidence predictors of this phenomenon are not well-known. The purpose study is ascertain proportion cancer survivors who experience potential contributing factors eyebrow associations between symptom mental health. Methods: Breast were invited participate in an ongoing longitudinal cohort study, Mayo Clinic Disease Registry (MCBDR), after having been seen...
Abstract Background: Retrospective studies suggest that breast cancer survivors report treatment-associated hair loss or thinning years after their initial diagnosis. This study investigates patient perceptions of alopecia persisting 6 the diagnosis cancer. Methods: Breast who had signed informed consent for participation in a prospective longitudinal cohort study, Mayo Clinic Disease Registry (MCBDR), approximately six prior, were mailed survey. survey asked about degree bother from and on...
12048 Background: Playing music has been an important part of human culture for millennia. Today more than half American households have at least one person who plays music, and in the UK 43% adults play instrument. Despite overlap between musicians people diagnosed with cancer, effect cancer treatment on musicianship not well-studied. We previously reported that 26% a musician breast survivor cohort difficulty after treatment, here we conduct further analysis to identify disease factors...
Cardiac and pulmonary allograft recipients represent a unique population, frequently interacting with support groups exhibiting intense curiosity about their pathology. Like other solid organ transplant patients, they have enduring frequent interaction the laboratory for routine surveillance.
Human papillomavirus (HPV) vaccine uptake remains suboptimal. Our stepped-wedge cluster randomized trial found that reminder-recall letters sent to parents of age-eligible children significantly increased compared usual care. Subsequently, we conducted a process evaluation assess the mechanisms letter's effectiveness. This study evaluated who remembered letter, use provided resources, and child vaccination status.
Abstract The Mayo Clinic Breast Disease Registry (MCBDR) was developed to serve as a cohort of newly diagnosed breast cancer patients address questions etiology, prognosis, and survivorship. Eligibility is limited 18 years or older with confirmed first stage 0-4 diagnosis within the last year. Consent completed via phone, patient portal, in-person. Upon enrollment, baseline questionnaire blood collection are completed. Annual follow-up surveys that capture BC outcomes sent all living...
Background: There are limited evidence-based data to guide treatment recommendations for breast cancer (BC) patients ≥80 years (P80+). Identifying and addressing unmet needs critical. Aims: Advocate-BREAST80+ compared the of P80+ vs. < 80 (P80−). Methods: In 12/2021, a REDCap survey was electronically circulated 6918 persons enrolled in Mayo Clinic Breast Disease Registry. The asked about concerns satisfaction with multiple aspects BC care. Results: Overall, 2437 participants responded...