A5064453966- BRCA gene mutations in cancer
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- PARP inhibition in cancer therapy
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- Global Cancer Incidence and Screening
- Cancer Cells and Metastasis
- Brain Metastases and Treatment
- Clusterin in disease pathology
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Economic and Financial Impacts of Cancer
- Breast Lesions and Carcinomas
- Radiopharmaceutical Chemistry and Applications
- Genetic Associations and Epidemiology
- Pharmacogenetics and Drug Metabolism
- Ovarian cancer diagnosis and treatment
- CRISPR and Genetic Engineering
- Nutrition, Genetics, and Disease
- Cancer Immunotherapy and Biomarkers
Erasmus MC Cancer Institute
2016-2025
Erasmus MC
2015-2024
Erasmus University Rotterdam
2011-2024
Biofrontera (Germany)
2016-2024
Harvard University
2022
Dana-Farber Cancer Institute
2022
Carrier (United States)
2021
Cohort (United Kingdom)
2021
Codarts Rotterdam
2020-2021
Leiden University Medical Center
2011-2019
ContextPersons with impaired glucose tolerance (IGT) are known to have an elevated risk of developing diabetes mellitus. Less is about among persons fasting (IFG) or normal levels.ObjectiveTo determine the incidence in relation baseline and postload levels other factors.Design, Setting, ParticipantsPopulation-based cohort study conducted from October 1989 February 1992 1342 nondiabetic white residents Hoorn, Netherlands, aged 50 75 years at baseline, whom plasma (FPG) 2 hours after a 75-g...
In healthy BRCA1/2 mutation carriers, bilateral risk-reducing mastectomy (BRRM) strongly reduces the risk of developing breast cancer (BC); however, no clear survival benefit BRRM over BC surveillance has been reported yet. this Dutch multicenter cohort study, we used multivariable Cox models with as a time-dependent covariable to estimate associations between and overall BC-specific mortality rates, separately for BRCA1 BRCA2 carriers. During mean follow-up 10.3 years, 722 out 1712 (42%)...
LBA1000 Background: The phase-3, randomized, investigator-initiated, nationwide SONIA trial is evaluating the efficacy, safety and cost-effectiveness of CDK4/6i added to either first- or second-line endocrine therapy (ET) in patients with HR+, HER2- ABC who have received no prior for ABC. addition ET improves progression-free (PFS) overall survival (OS) ABC, as initial treatment (first-line) after monotherapy (second-line). Most international guidelines advice first-line use, despite...
Abstract —Microalbuminuria (MA) is associated with increased cardiovascular and all-cause mortality. It has been proposed that MA reflects generalized atherosclerosis may thus predict To investigate this hypothesis, we studied the associations between, on one hand, peripheral arterial disease (PAD), a generally accepted marker of atherosclerosis, and, other mortality in an age-, sex-, glucose tolerance-stratified sample (n=631) population-based cohort aged 50 to 75 years followed...
Abstract —Increased levels of von Willebrand factor (vWf) and C-reactive protein (CRP) predict cardiovascular mortality in selected populations. It is uncertain whether vWf CRP a general population through similar pathways. This study investigated the association with all-cause among diabetic nondiabetic subjects. An age-, sex-, glucose tolerance–stratified sample (n=631) population-based cohort aged 50 to 75 years was followed prospectively for 5 years. After follow-up, 58 subjects had died...
Membrane-bound vascular cell adhesion molecule 1 (VCAM-1) allows the tethering and rolling of monocytes lymphocytes as well firm attachment transendothelial migration leukocytes. Soluble forms VCAM (sVCAM-1) may serve monitors increased expression membrane-bound VCAM-1 thus reflect progressive formation atherosclerotic lesions. Levels sVCAM-1 have been found to be among type 2 diabetic compared with nondiabetic subjects. To study association plasma concentration risk cardiovascular all-cause...
Abstract Purpose: Poly(ADP-ribose) polymerase (PARP) inhibitors are promising targeted treatment options for hereditary breast tumors with a homologous recombination (HR) deficiency caused by BRCA1 or BRCA2 mutations. However, the functional consequence of BRCA gene mutations is not always known and can be HR deficient other reasons than Therefore, we aimed to develop test determine activity in tumor samples facilitate selection patients eligible PARP inhibitor treatment. Experimental...
The high incidence of breast cancer has sparked the development novel targeted and personalized therapies. Personalization treatment requires reliable prediction chemotherapy responses in individual patients. Effective selection can prevent unnecessary that would mainly result unwanted side effects therapy. This be facilitated by characterization tumors using robust specific functional assays, which powerful ex vivo culture systems procedures to analyze response treatment. We optimized...
Several less-invasive staging procedures have been proposed to replace axillary lymph node dissection (ALND) after neoadjuvant chemotherapy (NAC) in patients with initially clinically node-positive (cN+) breast cancer, but these may fail detect residual disease. Owing the lack of high-level evidence, it is not yet clear which procedure most optimal ALND.To determine diagnostic accuracy radioactive iodine seed placement axilla sentinel biopsy (RISAS), a targeted procedure.This was...
Article5 January 2022Open Access Transparent process Pharmacological CDK4/6 inhibition reveals a p53-dependent senescent state with restricted toxicity Boshi Wang orcid.org/0000-0002-9257-6714 European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), Groningen, The Netherlands Search more papers by this author Marta Varela-Eirin orcid.org/0000-0002-0281-0678 Simone M Brandenburg orcid.org/0000-0001-6144-6194 Alejandra Hernandez-Segura Thijmen...