A5066977976- Pharmaceutical Practices and Patient Outcomes
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Pharmaceutical studies and practices
- Pharmacological Effects and Toxicity Studies
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Poisoning and overdose treatments
- Health Systems, Economic Evaluations, Quality of Life
- Medication Adherence and Compliance
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Treatments and Mutations
- Potassium and Related Disorders
- Pharmacy and Medical Practices
- PI3K/AKT/mTOR signaling in cancer
- Microscopic Colitis
- Renal cell carcinoma treatment
- Patient Safety and Medication Errors
- HER2/EGFR in Cancer Research
- Inflammatory Bowel Disease
- Pain Mechanisms and Treatments
- Cardiac Arrest and Resuscitation
- Magnesium in Health and Disease
- Biosimilars and Bioanalytical Methods
- Liver Diseases and Immunity
University of Groningen
2015-2024
Deventer Ziekenhuis
2015-2024
Center Point
2012
Pharmac
2008
Isala
2000-2007
Gelre Hospitals
2003
Potential drug–drug interactions (PDDIs) in patients with cancer are common, but have not previously been quantified for oral anticancer treatment. We assessed the prevalence and seriousness of potential PDDIs among ambulatory on A search was conducted a computer-based medication prescription system dispensing drugs to outpatients three Dutch centres. were identified using electronic (Drug Interaction Fact software) manual screening methods (peer-reviewed reports). In 898 included study,...
OBJECTIVE—Chromium treatment has been reported to improve glycemic control and insulin sensitivity in specific populations of patients with type 2 diabetes. The aim this study was determine the effect chromium on a Western population insulin-dependent RESEARCH DESIGN AND METHODS—In 6-month double-blind study, an HbA1c (A1C) >8% requirements >50 units/day were randomly assigned receive placebo or 500 1,000 μg daily form picolinate. primary efficacy parameter change A1C....
Tyrosine kinase inhibitors (TKIs) have rapidly become an established factor in oncology, and been shown to be effective a wide variety of solid hematologic malignancies. Use the oral administration route TKIs offers flexibility is convenient for patient; however, despite these advantages, also causes highly relevant new problem. Acid-inhibitory drugs, such as proton pump (PPIs), increase intragastric pH, which may subsequently decrease TKI solubility, bioavailability, treatment efficacy....
The aim of this study was to estimate the total economic and health related burden breast cancer in Netherlands. Data on incidence, prevalence, mortality survival were extracted from Dutch National Cancer Registry used calculate for overall, DCIS (stage 0), early- I), locally advanced- II-III) metastatic- IV) by age groups year (if applicable). overall incidence increased 103.4 up 153.2 per 100,000 women between 1990 2014. increase driven early as advanced metastatic remained stable. Between...
Abstract A sensitive and selective ultra‐high performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method for the simultaneous determination of seven oral oncolytics (two PARP inhibitors, i.e. olaparib niraparib, five tyrosine kinase cobimetinib, cabozantinib, dabrafenib, vemurafenib regorafenib, plus its active metabolite regorafenib M2) in EDTA plasma was developed validated. Stable isotope‐labelled internal standards were used each analyte. simple protein precipitation...
Pazopanib is taken fasted in a fixed oral daily dose of 800 mg. We hypothesized that ingesting pazopanib with food may improve patients’ comfort and reduce gastrointestinal (GI) adverse events. Therefore, we investigated the bioequivalent when compared mg fasted. In addition, differences GI toxicity, patient satisfaction, patient's preference for either intake. The intake 600 resulted exposure was preferred over standard without food. No were seen toxicities under both regimens. Patients...
The in vivo pharmacokinetics of gentamycin- loaded collagen fleeces humans have not been described the current literature. We therefore analyzed these when used treatment periprosthetic infections.Gentamycin concentrations were measured 19 consecutive patients with an acute infection. Each patient received 2-5 (130 mg gentamycin/fleece).Initially, blood concentration increased to 3.2-7.2 mg/L, depending on number that applied. serum peak resulted peak/MIC ratios 2.5-36 for P. aeruginosa, S....
Abstract Purpose Peripheral neuropathy (PN) is common in patients with multiple myeloma (MM). We hypothesized that the relationship between hypovitaminosis D and PN described diabetes mellitus may also be present MM patients. Methods To study this potential association, we assessed incidence of (vitamin < 75 nmol/L [= 30 ng/mL]) smouldering active two Dutch hospitals. Furthermore, a validated questionnaire was used to distinguish different grades. Results Of 120 included January 2017...