A5045583556- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Cardiac Arrhythmias and Treatments
- Heart Failure Treatment and Management
- Acute Myeloid Leukemia Research
- Blood Pressure and Hypertension Studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cardiovascular Issues in Pregnancy
- Intracranial Aneurysms: Treatment and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Lipoproteins and Cardiovascular Health
- Lymphoma Diagnosis and Treatment
- Bariatric Surgery and Outcomes
- Surgical Simulation and Training
- Pregnancy and preeclampsia studies
- Folate and B Vitamins Research
- Multiple Myeloma Research and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Antiplatelet Therapy and Cardiovascular Diseases
- Viral-associated cancers and disorders
- Medication Adherence and Compliance
- Rheumatoid Arthritis Research and Therapies
- Acute Myocardial Infarction Research
University Medical Center Groningen
2016-2025
Medisch Centrum Leeuwarden
2016-2025
University of Groningen
2015-2024
Wilhelmina Children's Hospital
2020
University Medical Center Utrecht
2020
Dialyse Centrum Groningen
2002-2016
Certe
2016
University of Amsterdam
2000-2015
Amsterdam UMC Location University of Amsterdam
2000-2015
Leiden University Medical Center
2010-2015
Aims Non-compliance in patients with heart failure (HF) contributes to worsening HF symptoms and may lead hospitalization. Several smaller studies have examined compliance HF, but all were limited as they only studied either the individual components of its related factors or several aspects without studying factors. The aims this study examine dimensions one population.
Heart failure (HF) disease management programs are widely implemented, but data about their effect on outcome have been inconsistent.The Coordinating Study Evaluating Outcomes of Advising and Counseling in Failure (COACH) was a multicenter, randomized, controlled trial which 1023 patients were enrolled after hospitalization because HF. Patients assigned to 1 3 groups: control group (follow-up by cardiologist) 2 intervention groups with additional basic or intensive support nurse specializing...
No data are available on the absolute risk of either venous thromboembolism (VTE) or arterial (ATE) in patients with nephrotic syndrome. Reported risks based multiple case reports and small studies mostly short-term follow-up. We assessed VTE ATE a large, single-center, retrospective cohort study attempted to identify predictive factors these patients.A total 298 consecutive syndrome (59% men; mean age, 42+/-18 years) were enrolled. Mean follow-up was 10+/-9 years. Nephrotic defined by...
The aim of this prospective study was to investigate the association between compliance with non-pharmacological recommendations (diet, fluid restriction, weighing, exercise) and outcome in patients heart failure (HF). In total 830 after an HF hospitalization participated (age 70 ± 11; left ventricular ejection fraction 34%). Compliance measured 1 month discharge; were followed for 18 months. Primary outcomes composite death or readmission number unfavourable days. Cox regression analysis...
The efficacy and safety of vitamin K antagonists (VKA) are related to the actual level anticoagulation (given as international normalized ratio, INR). It is often difficult maintain an optimal INR over time. We assessed clinical impact individual time spent within target range (ITTR) in 2304 consecutive patients with venous thromboembolism. Annual incidences recurrent thromboembolism major bleeding were 6.2% 2.8% respectively. relative risk (RR) was 4.5 [95% confidence interval (CI) 3.1-6.6,...
A randomized controlled trial.To evaluate the long-term efficacy of infliximab, a monoclonal antibody against tumor necrosis factor alpha (TNF-alpha), in patients with acute/subacute sciatica secondary to herniated disc.The results experimental studies and our open-label trial support use infliximab sciatica. Here we report 1-year (FIRST II, Finnish Infliximab Related STudy) evaluating safety single infusion for sciatic pain.Inclusion criteria were unilateral pain disc herniation concordant...
Background— Homozygous or double heterozygous factor V Leiden and/or prothrombin G20210A is a rare inherited thrombophilic trait. Whether individuals with this genetic background have an increased risk of recurrent venous thrombosis uncertain. Methods and Results— A case-control design within large cohort families thrombophilia was chosen to calculate the in homozygosity heterozygosity G20210A. Cases were thrombosis, controls those only 1 thrombosis. The consisted 788 thrombosis; 357 had...
Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating type of stroke associated with high morbidity and mortality. One the most feared complications an early rebleeding before aneurysm repair. Predictors for such often fatal are largely unknown. We therefore aimed to determine predictors after aSAH in relation time ictus.This observational prospective cohort study included all consecutive patients admitted between January 1998 December 2014 (n=1337) at our University Neurovascular...
Background and Purpose— Early prediction of clinical outcome after aneurysmal subarachnoid hemorrhage (aSAH) is still lacking accuracy. In this observational cohort study, we aimed to develop validate an accurate bedside model for aSAH, aid decision-making at early stage. Methods— For the development model, a prospectively kept single-center 1215 aSAH patients, admitted between 1998 2014, was used. temporal validation, prospective 224 consecutive patients from same center, 2015 2017,...
To evaluate the course of spinal radiographic progression for up to 8 years followup in a large cohort ankylosing spondylitis (AS) patients treated with tumor necrosis factor (TNF) inhibitors.Consecutive from Groningen Leeuwarden AS starting TNF inhibitors between 2004 and 2012 were included. Baseline biannual radiographs randomized TNF-naive scored chronologic order according modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). The (linear or nonlinear) was investigated using...
Hereditary deficiencies of protein S, C and antithrombin are known risk factors for first venous thromboembolism. We assessed the absolute recurrence, contribution concomitant thrombophilic defects in a large cohort families with these deficiencies. Annual incidence recurrence was estimated 130 deficient patients, separate estimates those each C, deficiency, eight non-deficient patients prior All were also tested factor V Leiden, prothrombin G20210A, high levels VIII, IX XI,...
Whether hereditary protein S, C, or antithrombin deficiency is associated with arterial thromboembolism (ATE) and whether history of venous in these subjects predisposes them to subsequent ATE have yet be determined.On the basis pedigree analysis, we enrolled a total 552 (52% women; mean age, 46+/-17 years), belonging 84 different kindreds, this retrospective family cohort study. Detailed information on previous episodes thromboembolism, ATE, anticoagulant use, atherosclerosis risk factors...
In Brief Study Design. A randomized controlled trial. Objectives. To evaluate the efficacy of infliximab, a monoclonal antibody against tumor necrosis factor (TNF)-α in setting. Summary Background Data. Recently, we obtained encouraging results an open-label study infliximab patients with disc herniation-induced sciatica. Furthermore, experimental studies support use Therefore, initiated randomized, trial (FIRST II, Finnish Infliximab Related STudy) to confirm single infusion for sciatic...