A5014115556- Ovarian cancer diagnosis and treatment
- Gastrointestinal Tumor Research and Treatment
- Palliative Care and End-of-Life Issues
- Endometrial and Cervical Cancer Treatments
- Gastric Cancer Management and Outcomes
- Cancer survivorship and care
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Childhood Cancer Survivors' Quality of Life
- Gastrointestinal disorders and treatments
- Sarcoma Diagnosis and Treatment
- Management of metastatic bone disease
- Chromatin Remodeling and Cancer
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- PI3K/AKT/mTOR signaling in cancer
- Patient Dignity and Privacy
- PARP inhibition in cancer therapy
- Genetic factors in colorectal cancer
- Olfactory and Sensory Function Studies
- Cancer Mechanisms and Therapy
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Cancer-related cognitive impairment studies
- Immunotherapy and Immune Responses
University of Groningen
2016-2025
University Medical Center Groningen
2016-2025
Netherlands Comprehensive Cancer Organisation
2023
Target (United States)
2018
Dialyse Centrum Groningen
2017
TiFN
2016
Erasmus MC
2009
Leiden University Medical Center
2009
Medisch Centrum Leeuwarden
2009
Maaslandziekenhuis
2009
LINICIANS PERCEIVE THE CARE they provide as inappropriate when feel that it clashes with their personal beliefs and/or professional knowledge. 15][6][7][8] ICU physicians may be troubled by a perceived lack of power to make the clinical decision most benefits specific patient. 5A survey among 504 Eu-
A strong vaccine-induced T cell response during standard-of-care chemotherapy correlates with survival in patients advanced cervical cancer.
Whether the quality of ethical climate in intensive care unit (ICU) improves identification patients receiving excessive and affects patient outcomes is unknown. In this prospective observational study, perceptions (PECs) by clinicians working 68 ICUs Europe USA were collected daily during a 28-day period. The was assessed via validated questionnaire. We compared combined endpoint (death, not at home or poor life 1 year) with PECs time from until written treatment-limitation decisions (TLDs)...
Apart from organizational issues, quality of inter-professional collaboration during ethical decision-making may affect the intention to leave one's job. To determine whether climate is associated with after adjustment for country, ICU and clinicians characteristics. Perceptions among working in 68 adult ICUs 12 European countries US were measured using a self-assessment questionnaire, together job characteristics intent as sub-analysis Dispropricus study. The validated questionnaire...
Activation of the epidermal growth factor receptor (EGFR) signaling pathway has been reported to induce resistance (chemo)radiation in cancers, such as head and neck cancer, whereas EGFR-targeted agents combination with seem improve treatment efficacy. The aim this study was determine relation between proteins involved EGFR response survival a large, well-documented series cervical cancer patients.Pretreatment tissue samples 375 consecutive International Federation Gynecologists...
The purpose of the current phase II single-arm clinical trial was to evaluate whether pretreatment with low-dose cyclophosphamide improves immunogenicity a p53-synthetic long peptide (SLP) vaccine in patients recurrent ovarian cancer. Patients cancer elevated serum levels CA-125 after primary treatment were immunized four times p53-SLP vaccine. Each immunization preceded by administration 300 mg/m2 intravenous as means affect regulatory T cells (Tregs). Vaccine-induced p53-specific...
Background Literature depicts differences in ethical decision-making (EDM) between countries and intensive care units (ICU). Objectives To better conceptualise EDM climate the ICU to validate a tool assess climates. Methods Using modified Delphi method, we built theoretical framework self-assessment instrument consisting of 35 statements. This Ethical Decision-Making Climate Questionnaire (EDMCQ) was developed capture three domains healthcare: interdisciplinary collaboration communication;...
Tyrosine kinase inhibitors (TKIs) have rapidly become an established factor in oncology, and been shown to be effective a wide variety of solid hematologic malignancies. Use the oral administration route TKIs offers flexibility is convenient for patient; however, despite these advantages, also causes highly relevant new problem. Acid-inhibitory drugs, such as proton pump (PPIs), increase intragastric pH, which may subsequently decrease TKI solubility, bioavailability, treatment efficacy....
Abstract Background Five percent of gastrointestinal stromal tumors (GISTs) are primarily localized in the rectum. We analyzed outcome multimodality treatment for rectal GIST a multicenter retrospective series. Methods All surgically treated patients with were identified from four specialized centers Netherlands. Primary endpoints disease‐free survival (DFS) and overall (OS). Results Thirty‐two (22 men 10 women) GISTs identified. Twenty‐two received imatinib before surgery median 9 (range...
We examined differences in distress levels and Distress Thermometer (DT) cutoff scores between different cancer types. The effect of socio-demographic illness-related variables on was also examined.One thousand three hundred fifty patients (response = 51%) completed questions variables, the Dutch version DT Problem List, Hospital Anxiety Depression Scale. Receiver operating characteristics analyses were performed to determine specific scores. Univariate multivariate effects (including type)...
The estrogen receptor α (ERα) is expressed in approximately 70% of ovarian cancer tumors. PET tumor ERα expression with the tracer 16α-<sup>18</sup>F-fluoro-17β-estradiol (<sup>18</sup>F-FES) may be valuable to select patients for endocrine therapy. aim this study was evaluate feasibility <sup>18</sup>F-FES determine noninvasively epithelial patients. <b>Methods:</b><sup>18</sup>F-FES PET/CT performed shortly before cytoreductive surgery. Tumor uptake quantified all lesions 10 mm or greater...