A5010294005- Breast Cancer Treatment Studies
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Global Cancer Incidence and Screening
- Advances in Oncology and Radiotherapy
- Chemotherapy-induced cardiotoxicity and mitigation
- Childhood Cancer Survivors' Quality of Life
- Breast Implant and Reconstruction
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Radiation Dose and Imaging
- Breast Lesions and Carcinomas
- Cardiac Imaging and Diagnostics
- Cancer survivorship and care
- Radiomics and Machine Learning in Medical Imaging
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Endometrial and Cervical Cancer Treatments
- Neuroblastoma Research and Treatments
- Effects of Radiation Exposure
- Palliative Care and End-of-Life Issues
- BRCA gene mutations in cancer
- Economic and Financial Impacts of Cancer
- HER2/EGFR in Cancer Research
- Patient-Provider Communication in Healthcare
University of Groningen
2015-2024
University Medical Center Groningen
2015-2024
Princess Máxima Center
2020-2024
Dialyse Centrum Groningen
2014-2022
Migration Institute of Australia
2022
Hanze University of Applied Sciences
2019
Siemens (Germany)
2017
Roche (Bosnia-Herzegovina)
2017
AbbVie (Bahamas)
2017
Beatson West of Scotland Cancer Centre
2013
Purpose A relationship between mean heart dose (MHD) and acute coronary event (ACE) rate was reported in a study of patients with breast cancer (BC). The main objective our cohort to validate this investigate if other dose-distribution parameters are better predictors for ACEs than MHD. Patients Methods consisted 910 consecutive female BC treated radiotherapy (RT) after breast-conserving surgery. primary end point cumulative incidence within 9 years follow-up. Both MHD various the cardiac...
Activation of the epidermal growth factor receptor (EGFR) signaling pathway has been reported to induce resistance (chemo)radiation in cancers, such as head and neck cancer, whereas EGFR-targeted agents combination with seem improve treatment efficacy. The aim this study was determine relation between proteins involved EGFR response survival a large, well-documented series cervical cancer patients.Pretreatment tissue samples 375 consecutive International Federation Gynecologists...
In left-sided breast cancer radiotherapy, tangential intensity modulated radiotherapy combined with breath-hold enables a dose reduction to the heart and left anterior descending (LAD) coronary artery. Aim of this study was investigate added value proton therapy (IMPT) regard decreasing radiation these structures.In comparative planning study, four treatment plans were generated in 20 patients: an IMPT plan IMRT plan, both free-breathing. At least 97 % target volume had be covered by at 95...
In 2011, the NABON Breast Cancer Audit (NBCA) was instituted as a nation-wide audit to address quality of breast cancer care and guideline adherence in Netherlands. The development NBCA results 4 years auditing are described.Clinical pathological characteristics patients diagnosed with invasive or situ carcinoma (DCIS) information regarding diagnosis treatment collected all hospitals (n = 92) Thirty-two indicators measuring structure, processes outcomes were evaluated over time compared...
The purpose of the study was to determine impact young age on health-related quality life (HRQoL) by comparing HRQoL younger and older breast cancer patients, corrected for confounding, patients a general Dutch population.The population consisted survivors (stage 0-III) after breast-conserving surgery radiotherapy. Health-related prospectively assessed using EORTC QLQ-C30 QLQ-BR23 questionnaires. association between (⩽50; 51-70; ⩾70 years) over time analysed with mixed modelling. clinical...
Our study aimed to provide a comprehensive overview of trends in incidence, survival, mortality and treatment first primary invasive breast cancer (BC), according age, stage receptor subtype the Netherlands between 1989 2017. Data from all women diagnosed with I IV BC (N = 320 249) were obtained Cancer Registry. general population data retrieved Statistics Netherlands. Age-standardised incidence rates calculated annual percentage change (APC) average (AAPC) statistics. The relative survival...
To determine whether the use of prophylactic antibiotics is effective in prevention postoperative wound infection after Lichtenstein open mesh inguinal hernia repair.A recent Cochrane meta-analysis (2003) concluded that "antibiotic prophylaxis for elective repair cannot be firmly recommended or discarded."Patients with a primary scheduled were randomized to preoperative single dose 1.5 g intravenous cephalosporin placebo. Patients recurrent hernias, immunosuppressive diseases, allergies...
Pediatric cranial radiotherapy (CrRT) markedly increases risk of meningiomas. We studied meningioma factors with emphasis on independent and joint effects CrRT dose, exposed volume, exposure age, chemotherapy.The Dutch Cancer Oncology Group-Long-Term Effects after Childhood (DCOG-LATER) cohort includes 5-year childhood cancer survivors (CCSs) whose cancers were diagnosed in 1963-2001. Histologically confirmed benign meningiomas identified from the population-based Pathology Registry (PALGA;...
PurposeTo assess the feasibility of magnetic resonance imaging (MRI)-only treatment planning for photon and proton radiotherapy in children with abdominal tumours.Materials methodsThe study was conducted on 66 paediatric patients Wilms' tumour or neuroblastoma (age 4 ± 2 years) who underwent MR computed tomography (CT) acquisition same day as part clinical protocol. MRI intensities were converted to CT Hounsfield units (HU) by means a UNet-like neural network trained generate synthetic (sCT)...
Abstract Background Understanding cancer heterogeneity, its temporal evolution over time, and the outcomes of guided treatment depend on accurate data collection in a context routine clinical care. We have developed hospital-based data-biobank for oncology, entitled OncoLifeS ( Oncological Life Study: Living well as survivor ), that links with preserved biological specimens quality life assessments. The aim this study is to describe organization development research. Results enrolled 3704...
ObjectiveDose prediction using deep learning networks prior to radiotherapy might lead tomore efficient modality selections. The study goal was predict proton and photon dose distributions based on the patient-specific anatomy assess their clinical usage for paediatric abdominal tumours.Material methodsData from 80 patients with neuroblastoma or Wilms’ tumour included. Pencil beam scanning (PBS) (5 mm/ 3%) volumetric-modulated arc therapy (VMAT) plans mm) were robustly optimized internal...
PurposeRadiation-induced acute coronary events (ACEs) may occur as a treatment-related late adverse effect of breast cancer (BC) radiation. However, the underlying mechanisms behind this radiation-induced cardiac disease remain to be determined. The objective study was test hypothesis that radiation dose calcified atherosclerotic plaques in left anterior descending artery (LAD) is better predictor for ACEs than whole heart or ventricle patients with BC treated therapy.Methods and...
Proton therapy is a radiation technique that yields less dose in normal tissues than photon therapy. In the Netherlands, proton reimbursed if reduced to predicted translate into prespecified reduction toxicity, based on nationally approved validated models. The aim of this paper present development national indication protocol for (NIPP) model-based selection breast cancer patients and report first clinical experiences.A working group (PWG-BC) screened literature prognostic models able...
SUMMARY The peplomer gene of feline infectious peritonitis virus (FIPV) strain 79-1146 was isolated from a genomic cDNA library by differential hybridization with RNA 2 and 3 as probes. From the nucleotide sequence primary translation product 1452 residues (Mr 160472) predicted, containing an N-terminal signal sequence, C-terminal transmembrane segment 35 potential N-linked glycosylation sites. By SI nuclease analysis 5′ end presumptive body located at about 30 nucleotides upstream...