A5101478350- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Cancer Risks and Factors
- Advanced Breast Cancer Therapies
- BRCA gene mutations in cancer
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal Cancer Screening and Detection
- HIV/AIDS Impact and Responses
- Cancer Treatment and Pharmacology
- Economic and Financial Impacts of Cancer
- HER2/EGFR in Cancer Research
- Patient-Provider Communication in Healthcare
- Metabolism, Diabetes, and Cancer
- Estrogen and related hormone effects
- Head and Neck Cancer Studies
- Lymphatic System and Diseases
- Sports Analytics and Performance
- Healthcare cost, quality, practices
- Global Maternal and Child Health
- Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Nutrition, Genetics, and Disease
- Clinical practice guidelines implementation
University of Auckland
2015-2025
Waikato District Health Board
2015-2024
German National Bone Marrow Donor Registry
2024
Waikato Hospital
2008-2023
University of Waikato
2012-2023
Wakefield Hospital
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2018
European Institute of Oncology
2018
Scunthorpe General Hospital
2016
Breast Cancer Trials
2013-2014
Abstract Background: Aromatase inhibitors (AI) are accepted as adjuvant endocrine therapy for hormone receptor-positive (HR+) postmenopausal early breast cancer (EBC) with superior efficacy to tamoxifen. However, because of the increased bone loss associated use AI, three international randomised studies Z-FAST, ZO-FAST and E-ZO-FAST were performed evaluate protective effects zoledronic acid (ZOL). These showed that mineral density (BMD) AI can effectively be prevented by ZOL. In addition,...
Background: The National Breast Cancer Audit Database of the Society Surgeons Australia and New Zealand is used by surgeons to monitor treatment quality for research. About 60% early invasive female breast cancers in are recorded. objectives this study are: (1) investigate associations socio-demographic, health-system clinical characteristics with cancer mastectomy compared conserving surgery; (2) consider service delivery implications. Materials Methods: Bi-variable multivariable analyses...
aim: The objectives of this study are to investigate whether diabetes affects the systemic treatment breast cancer. methods: Patients diagnosed with invasive cancer between 2005 and 2020 were identified from Te Rēhita Mate Ūtaetae – Breast Cancer Foundation National Register. Logistic regression modelling was used estimate odds ratios (ORs) 95% confidence intervals (95% CIs) for outcomes endocrine therapy estrogen receptor+/progesterone receptor+ cancer, targeted human epidermal growth...
The objective of this study is to investigate the influence diabetes on breast cancer-specific survival among women with cancer in Aotearoa/New Zealand.
To investigate person, cancer and treatment determinants of immediate breast reconstruction (IBR) in Australia.Bi-variable multi-variable analyses the Quality Audit database.Of 12,707 invasive cancers treated by mastectomy circa 1998-2010, 8% had IBR. This proportion increased over time reduced from 29% women below 30 years to approximately 1% those aged 70 or more. Multiple regression indicated that other IBR predictors included: high socio-economic status; private health insurance; being...
The study aim was to determine whether age is an independent risk factor for survival from early invasive breast cancer in contemporary Australian clinical settings. included 31 493 cancers diagnosed 1998-2005. Risk of death compared by age, without and with adjustment factors, using Cox proportional hazard regression. elevated larger size, higher grade, positive nodal status, oestrogen receptor negative vascular invasion multiple foci. Ductal lesions presented a than other lesions....
Abstract Background Indigenous M āori are known to experience inferior quality cancer care compared with non‐ I ndigenous E uropeans in N ew Z ealand. However, limited data available on ethnic/socio‐economic differences surgical treatment of breast cancer, or reasons for such variations within the local context. We investigated rates mastectomy, sentinel node biopsy ( SNB ), post‐mastectomy reconstruction and definitive therapy Methods A retrospective review prospective W aikato Breast...
Indigenous and/or minority ethnic women are known to experience longer delays for treatment of breast cancer, which has been shown contribute inequities in cancer mortality. We examined factors associated with delay adjuvant chemotherapy and radiotherapy its impact on the mortality inequity between Māori European New Zealand. All newly diagnosed invasive non-metastatic during 1999–2012, who underwent (n = 922) or radiation therapy 996) as first after surgery were identified from Waikato...
Beta blockers (BB) have been associated with improved, worsened, or unchanged breast cancer outcomes in previous studies. This study examines the association between post-diagnostic use of BBs and death from a large, representative sample New Zealand (NZ) women cancer.Women diagnosed first primary 2007 2016 were identified four population-based regional NZ registries linked to national pharmaceutical data, hospital discharges, records. The median follow-up time was 4.51 years. Cox...
Background: The Quality Audit (BQA) program of the Breast Surgeons Australia and New Zealand (NZ) collects data on early female breast cancer its treatment. BQA covered approximately half all cancers diagnosed in NZ during roll-out 1998-2010. Coverage increased progressively to about 80% by 2008. This is biggest database outside Cancer Registry it includes clinical management not collected Registry. We used these compare socio-demographic characteristics survivals ethnicity. Materials...
Abstract Objective: Menopausal status at diagnosis is an important factor for the management of breast cancer in younger women, and may affect prognosis these women. We aim to examine association menopausal risk metastatic relapse stage I-III cancer. Methods: included women diagnosed with 45 55 years Auckland Waikato Breast Cancer Registers. Cumulative incidence was examined by age group after stratifying estrogen receptor (ER) progesterone (PR) status. Cox proportional hazards model used...
This study aims to examine whether diabetes has an impact on the use of surgery and adjuvant radiotherapy in treating women with localised breast cancer.Women diagnosed stage I-III cancer between 2005 2020 were identified from Te Rēhita Mate Ūtaetae-Breast Cancer Foundation New Zealand National Register, status determined using Zealand's Virtual Diabetes Register. The treatments examined included conserving (BCS), mastectomy, reconstruction after BCS. Logistic regression modelling was used...
Abstract In vivo labelling of human breast tumours with 5-bromo-2′-deoxyuridine and analysis proliferation by multiparameter flow cytometry is a new tool which the index, S phase duration (Ts) potential doubling time (Tpot) tumour can be estimated. Tumour specimens from 75 patients invasive carcinoma were studied. Six could not analysed, Ts Tpot values calculated for further 18. The median index (n = 69) was 4.2 per cent. 51) 8.7 h 8.2 days. intra-assay coefficient variation determination...
Objective To investigate patient, cancer and treatment factors associated with the residence of female breast patients in lower socioeconomic areas Australia to better understand that may contribute their poorer outcomes. Methods Bivariable multivariable analyses were performed using Breast Quality Audit database Surgeons New Zealand. Results Multivariable regression indicated from are more likely live remote be treated at regional than major city centres. Although they appeared equally...
To investigate patient, cancer and treatment characteristics in females with breast from more remote areas of Australia, to better understand reasons for their poorer outcomes, bi-variable multivariable analyses were undertaken using the National Breast Cancer Audit database Society Surgeons Australia New Zealand. Results indicated that patients likely be lower socio-economic status treated earlier diagnostic epochs at inner regional rather than major city centres. They also by low case load...