A5041531792- Glioma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Cancer Treatment and Pharmacology
- Breast Lesions and Carcinomas
- DNA Repair Mechanisms
- Angiogenesis and VEGF in Cancer
- Nonmelanoma Skin Cancer Studies
- Cancer survivorship and care
- Prostate Cancer Treatment and Research
- Effects of Radiation Exposure
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Oral health in cancer treatment
- Chemotherapy-related skin toxicity
- PARP inhibition in cancer therapy
- Meningioma and schwannoma management
- Head and Neck Cancer Studies
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Cancer Diagnosis and Treatment
McGill University
2013-2024
Jewish General Hospital
2015-2024
McGill University Health Centre
2003-2023
Montreal Neurological Institute and Hospital
2013-2022
University of Manitoba
2019
Western University
2019
University of Calgary
2019
McMaster University
2019
Okanagan University College
2019
University of British Columbia
2019
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Abstract In this study, we sought to explore the merit of proteomic profiling strategies in patients with cancer before and during radiotherapy an effort discover clinical biomarkers radiation exposure. Patients a diagnosis provided informed consent for enrollment on study permitting collection serum immediately course therapy. High-resolution surface-enhanced laser desorption ionization-time flight (SELDI-TOF) mass spectrometry (MS) was used generate high-throughput profiles unfractionated...
Background and Purpose: No longer considered a single disease entity, breast cancer is being classified into several distinct molecular subtypes based on gene expression profiling. These appear to carry prognostic implications have the potential be incorporated treatment decisions. In this study, we evaluated patterns of local recurrence (LR), distant metastasis (DM), association survival with subtype in patients post–adjuvant radiotherapy setting. Material Methods: The medical records 1,088...
2008 Background: For non-small cell lung cancer (NSCLC) with brain metastases (BM) stereotactic radiosurgery (SRS) is the current preferred therapy. Due to frequent intracranial failures, there a high unmet need for salvage therapies. Whole radiotherapy (WBRT) reduces failure but used less frequently due cognitive consequences. Tumor Treating Fields (TTFields) are electric fields that disrupt division and have shown improved survival safety in patients glioblastoma metastatic NSCLC. Phase 3...
Perinatal hypoxic/ischemic (HI) brain injury is a major clinical problem with devastating neurodevelopmental outcomes in neonates. During HI injury, dysregulated factor production contributes to microvascular impairment. Glycolysis-derived lactate accumulated during ischemia has been proposed protect against ischemic but its mechanism of action poorly understood. Herein, we hypothesize that via G-protein coupled receptor (GPR81) controls postnatal angiogenesis and plays protective role after...
Purpose To determine the predictive value of urinary levels two angiogenic factors, vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMPs), in a longitudinal study to their correlation with 1-year progression-free survival patients cancer. Patients Methods VEGF MMP were measured urine 65 cancer at first evaluation, during therapy, follow-up (n = 242); normalized by creatinine levels; compared 16 healthy controls. The initial trends MMPs was assessed using two-sample...
Abstract Experiments described herein were designed to evaluate the performance characteristics of a flow cytometry‐based system that scores incidence peripheral blood micronucleated reticulocytes (MN‐RETs). These procedures represent continued refinement previously reported anti‐CD71‐based method (Dertinger et al. [1996]: Mutat Res 371:283–292), with following modifications: incorporation third fluorescent label exclude platelets from MN‐RET region, and use CD71‐associated fluorescence...
Abstract Purpose: Optical coherence tomography (OCT) imaging was evaluated to determine if radiation-induced mucosal damage could be noninvasively monitored in real time and correlated with histopathologic findings. Experimental Design: Female C3H mice, ages 7 9 weeks, four per group, were immobilized a custom-made Lucite jig received 0, 15, 22.5, 25 Gy single fraction their oral cavity. OCT images acquired of proximal, middle, distal aspects the dorsum tongue on days 1, 3, 5,...
Background Prostate cancer (PCa) is a progressive disease and the most diagnosed in men. The current standard of care for high‐risk localized PCa combination androgen deprivation therapy (ADT) radiation (XRT). majority these patients however become resistant due to incomplete responses ADT as result selective cells maintaining receptor (AR) activity. Improvement can be made if increasing radiosensitivity realized. Therefore, aim this study investigate efficacy next‐generation drug...
Background Recent developments in artificial intelligence suggest that radiomics may represent a promising non-invasive biomarker to predict response immune checkpoint inhibitors (ICIs). Nevertheless, validation of algorithms independent cohorts remains challenge due variations image acquisition and reconstruction. Using radiomics, we investigated the importance scan normalization as part broader machine learning framework enable model external generalizability ICI non-small cell lung cancer...
Adult medulloblastoma is a rare disease for which there no internationally accepted standard of care. Treatment regimens have typically been modeled after pediatric protocols. We sought to review the presentation, management, and outcome patients with adult treated at McGill University teaching hospitals over past 18 years.Medical records were reviewed gather demographic clinical data including presenting symptoms, tumor characteristics, survival, treatment toxicity.Twenty-five identified....
The authors reviewed their institutional experience with pure low-grade oligodendroglioma (LGO), correlating outcomes several variables of possible prognostic values.Sixty-nine patients WHO-classified LGOs were treated between 1992 and 2006 at the McGill University Health Center. Clinical, pathological, radiological records carefully reviewed. Demographic characteristics; nature duration presenting symptoms; baseline neurological function; extent resection; Karnofsky Performance Scale score;...
Radiation-induced dermatitis is a common side effect of breast irradiation, with hypofractionation being well-known risk factor. In the context widespread adoption hypofractionated radiotherapy, we evaluated radiotherapy on incidence skin toxicity in patients receiving adjuvant chemotherapy.We retrospectively reviewed records cancer treated from 2004 to 2006 at single institution. Patients undergoing lumpectomy or without chemotherapy followed by consisting 42.4 Gy 16 fractions were included...
This pilot prospective study sought to determine whether dynamic contrast enhanced MRI (DCE-MRI) could be used as a clinical imaging biomarker of tissue toxicity from whole brain radiotherapy (WBRT).14 patients who received WBRT were imaged using DCE-MRI prior and at 8-weeks, 16-weeks 24-weeks after the initiation WBRT. Twelve also enrolled in RTOG 0614 trial, which randomized use placebo or memantine. After unblinding treatments by patients, measures tumor normal appearing white matter...