A5072096785- Colorectal Cancer Treatments and Studies
- Glioma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Medical History and Innovations
- Breast Cancer Treatment Studies
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Carcinogens and Genotoxicity Assessment
- Genetic factors in colorectal cancer
- Acute Lymphoblastic Leukemia research
- Histiocytic Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- DNA Repair Mechanisms
- Neuroendocrine Tumor Research Advances
- Breast Lesions and Carcinomas
- Antifungal resistance and susceptibility
- Advanced Breast Cancer Therapies
- Histone Deacetylase Inhibitors Research
- IgG4-Related and Inflammatory Diseases
- Nail Diseases and Treatments
- Colorectal Cancer Screening and Detection
- Social Media in Health Education
- Airway Management and Intubation Techniques
- BRCA gene mutations in cancer
McGill University
2015-2022
University at Buffalo, State University of New York
2021
University of Rochester Medical Center
2020
Washington University in St. Louis
2020
Georgetown University Medical Center
2020
Georgetown University
2020
Yale University
2020
The Ohio State University
2020
Triological Society
2020
California Institute of Behavioral Neurosciences and Psychology (United States)
2020
Background and Purpose: No longer considered a single disease entity, breast cancer is being classified into several distinct molecular subtypes based on gene expression profiling. These appear to carry prognostic implications have the potential be incorporated treatment decisions. In this study, we evaluated patterns of local recurrence (LR), distant metastasis (DM), association survival with subtype in patients post–adjuvant radiotherapy setting. Material Methods: The medical records 1,088...
Abstract We previously described flow cytometry‐based methods for scoring the incidence of micronucleated reticulocytes (MN‐RET) and PIG‐A mutant phenotype (MUT RET) in rodent human blood samples. The current report describes important methodological improvements analyses, including immunomagnetic enrichment CD71‐positive prior to MN‐RET scoring, procedures storing frozen later analysis. Technical replicate variability MUT RET frequencies based on specimens from 14 subjects, intra‐subject...
Since the end of 1980s, magnitude survival prolongation or mortality reduction has not been same for adolescents and young adults (ayas) with cancer as their older younger counterparts. Precise reasons those observations are unknown, but differences have attributed in part to delays diagnosis treatment. In 2003 at Jewish General Hospital, we developed first Canadian multidisciplinary aya oncology clinic better serve this unique patient population. The aim present study was develop an...
Background: The use of bevacizumab in the management glioblastoma multiforme (gbm) remains controversial. In Canada, is approved for treatment recurrent gbm. We describe a pattern progression across lines Methods: During 2008–2014, 64 patients diagnosed with gbm were treated at McGill University hospitals. Of those patients, 30 (46.9%) received first line (B1L), and 34 (53.1%) it second beyond (B2L+). average length was 24.4 weeks (range: 0–232.7 weeks). patterns categorized as local,...
Objective 1) To assess the feasibility of reconstructing 2‐cm‐long circumferential tracheal defects with a 3D printed polycaprolactone (PCL) implant in rabbits. 2) evaluate endoscopic, histologic, and functional characteristics PCL over time. Methods Ten New Zealand rabbits were included this study. A was created. All underwent surgical excision cm segment cervical trachea, which reconstructed implant. Rabbits sacrificed at following time points: 0, 4, 5, 6, 7 weeks postoperatively. At these...
Invasive mucinous carcinoma of the breast is mostly associated with invasive no special type (NST) and sometimes neuroendocrine tumors such as solid papillary carcinoma. Extracellular mucin production in lobular (ILC) extremely rare. To best our knowledge only 18 cases have been described literature. Here we present a unique case pleomorphic-type (IPTLC) presenting on core needle biopsy. discuss impact ways to suspect case.
The etiology of distal site cancers in inflammatory bowel disease (IBD) is not well understood and requires further study. We investigated whether pediatric IBD patients' blood cells exhibit elevated levels genomic damage by measuring the frequency mutant phenotype (CD59-/CD55-) reticulocytes (MUT RET) as a reporter PIG-A mutation, micronucleated (MN-RET) an indicator chromosomal damage. patients (n = 18 new-onset disease, 46 established disease) were compared to age-matched controls...
Despite lack of a true comparative study, the folfox (5-fluorouracil-leucovorin-oxaliplatin) and capox (capecitabine-oxaliplatin) regimens are believed to be similar in their efficacy tolerability treatment stage iii colorectal cancer. However, that belief has been disputed, because real-life data suggest regimen is more toxic, leading frequent reductions delivered dose intensity-thus raising questions about effect intensity on clinical outcomes.A retrospective review for two Canadian...
Congenital Langerhans cell histiocytosis (LCH) (formerly called Letterer–Siwe disease) is characterized by a clonal proliferation of cells occurring in children at birth and manifests typically with multifocal cutaneous lesions, hepatosplenomegaly, lymphadenopathy, pulmonary destructive osteolytic bone lesions. We present case LCH involving multiple systems high-risk organs (LCH MS-RO+), 32-week stillborn from 20-year-old G2A1. The fetus was mildly hydropic pale. Apart maceration, the skin...
Inflammatory bowel disease (IBD) is an important risk factor for gastrointestinal cancers. Inflammation and other carcinogenesis-related effects at distal, tissue-specific sites require further study. In order to better understand if systemic genotoxicity associated with IBD, we exposed mice dextran sulfate sodium salt (DSS) measured the incidence of micronucleated cells (MN) Pig-a mutant phenotype in blood erythrocyte populations. one study, 8-week-old male CD-1 were 0, 1, 2, 3 or 4% w/v...
BACKGROUND: RTOG 0825 and AVAGlio studies showed mixed survival results when bev was added to first line GBM treatment. In North America, use of is only approved for recurrent disease. Others have explored the reasons failure; two hypotheses included 1) promoting distant diffuse PP as a resistance mechanism 2) AEs related bev. This study undertaken describe compare PPs associated with in newly diagnosed GBM. METHODS: Sixty-four patients treated at McGill University Hospitals between...
e14664 Background: Standard of care in the treatment stage III colorectal cancer (CRC) involves 6 months adjuvant combination chemotherapy with 5-FU and oxaliplatin. Despite lack true comparative study, 2 regimens FOLFOX (MOSAIC trial) CAPOX (XELOXA are believed to be similar their efficacy tolerability. However, latter has been disputed as real-life data presented from Canada shown more toxic, leading frequent rate reduction its dose intensity. Consequently, impact on clinical outcomes...