A5091336952- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Glioma Diagnosis and Treatment
- MRI in cancer diagnosis
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Meningioma and schwannoma management
- Advanced X-ray and CT Imaging
- Cancer, Hypoxia, and Metabolism
- Radiation Therapy and Dosimetry
- Ultrasound and Hyperthermia Applications
- Medical Image Segmentation Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging and Analysis
- Radiopharmaceutical Chemistry and Applications
- Urologic and reproductive health conditions
- Photoacoustic and Ultrasonic Imaging
- Effects of Radiation Exposure
- Angiogenesis and VEGF in Cancer
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer Immunotherapy and Biomarkers
- Radiation Dose and Imaging
Centre Hospitalier de l’Université de Montréal
2016-2025
Deleted Institution
2024
Hôpitaux Universitaires de Strasbourg
2024
University of Toronto
2011-2022
Université de Montréal
2016-2021
University Health Network
2011-2021
Université Laval
2019
McGill University Health Centre
2019
Lyon College
2019
Hospices Civils de Lyon
2019
<h3>Importance</h3> Whole brain radiotherapy (WBRT) significantly improves tumor control in the after stereotactic radiosurgery (SRS), yet because of its association with cognitive decline, role treatment patients metastases remains controversial. <h3>Objective</h3> To determine whether there is less deterioration at 3 months SRS alone vs plus WBRT. <h3>Design, Setting, and Participants</h3> At 34 institutions North America, 1 to were randomized receive or WBRT between February 2002 December...
Abstract BACKGROUND Between 1979–1987, the National Cancer Institute conducted a randomized, prospective study of mastectomy (MT) versus breast conservation therapy (BCT) in treatment patients with early‐stage carcinoma. After median potential follow‐up 18.4 years, authors present updated results. METHODS informed consent was obtained from each patient, 237 evaluable women clinical AJCC Stage I and II carcinoma were enrolled on an institutionally reviewed protocol randomly assigned to...
Abstract Purpose: Tumor hypoxia is an important determinant of outcome in many human malignancies and associated with treatment resistance metastases. The aim this study was to determine the effect patients prostate cancer treated radiotherapy. Experimental Design: measured 247 clinically localized before radiotherapy, or without hormonal therapy. median pO2 6.8 mm Hg hypoxic percentage less than 10 (HP10) 63%. follow-up 6.6 years. Results: 5-year biochemical relapse-free rate (bRFR) 78%....
This paper reports a novel remotely actuated manipulator for access to prostate tissue under magnetic resonance imaging guidance (APT-MRI) device, designed use in standard high-field MRI scanner. The device provides three-dimensional guided needle placement with millimeter accuracy physician control. Procedures enabled by this include biopsy, fiducial marker placements, and therapy delivery. Its compact size allows both cylindrical open configuration scanners. Preliminary vivo canine...
LBA4 Background: WBRT significantly improves tumor control in the brain after SRS, yet role of adjuvant remains undefined due to concerns regarding neurocognitive risks. Methods: Patients with 1-3 metastases, each < 3 cm by contrast MRI, were randomized SRS alone or + and underwent cognitive testing before treatment. The primary endpoint was progression (CP) defined as decline > 1 SD from baseline any 6 tests at months. Time CP estimated using cumulative incidence adjusting for...
Abstract A technique for transperineal high‐dose‐rate (HDR) prostate brachytherapy and needle biopsy in a standard 1.5 T MRI scanner is demonstrated. In each of eight procedures (in four patients with intermediate to high risk localized cancer), MRI‐guided biopsies were obtained followed by placement 14–15 hollow catheters HDR brachytherapy. Mean needle‐placement accuracy was 2.1 mm, 95% errors less than 4.0 the maximum error 4.4 mm. addition guiding needles catheters, MR images also used...
Abstract In this study, we sought to explore the merit of proteomic profiling strategies in patients with cancer before and during radiotherapy an effort discover clinical biomarkers radiation exposure. Patients a diagnosis provided informed consent for enrollment on study permitting collection serum immediately course therapy. High-resolution surface-enhanced laser desorption ionization-time flight (SELDI-TOF) mass spectrometry (MS) was used generate high-throughput profiles unfractionated...
Abstract Hypoxia is a feature of many human malignancies, and leads to aggressive clinical behavior recurrence after treatment. Here, we show for the first time that androgen withdrawal reduces prostate cancer hypoxia in patients. Oxygen measurements were done 248 patients with clinically localized prior radiotherapy, showed potential biological significance. In 22 these patients, oxygen levels measured both before 30 145 days antagonist bicalutamide. There was significant reduction tumor (P...
Purpose: To explore the relationship between oxygen-sensitive Magnetic Resonance Imaging (MRI) and oxygen measurements in prostate cancer.
This paper reports the development, evaluation, and first clinical trials of access to prostate tissue (APT) II system-a scanner independent system for magnetic resonance imaging (MRI)-guided transrectal interventions. The utilizes novel manipulator mechanics employing a steerable needle channel six degree-of-freedom hybrid tracking method, comprising passive fiducial initial registration subsequent incremental motion measurements. Targeting accuracy in phantom experiments two human-subject...
Abstract Purpose: To evaluate regional and temporal changes in apparent diffusion coefficient (ADC) T 2 relaxation during radiation therapy (RT) patients with low intermediate risk localized prostate cancer. Materials Methods: Seventeen enrolled on a prospective clinical trial where MRI was acquired every weeks throughout eight of image‐guided IMRT (78 Gy/39 fractions). ADC quantification used entire prostate, central gland, benign peripheral zone, tumor‐dense regions‐of‐interest, mean...