A5028539104- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Growth Hormone and Insulin-like Growth Factors
- Cancer Treatment and Pharmacology
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- TGF-β signaling in diseases
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- Colorectal Cancer Treatments and Studies
- Cancer-related Molecular Pathways
- Cell Adhesion Molecules Research
- Cancer, Stress, Anesthesia, and Immune Response
- Glycosylation and Glycoproteins Research
- Breast Lesions and Carcinomas
- Metabolism, Diabetes, and Cancer
- BRCA gene mutations in cancer
- Prostate Cancer Treatment and Research
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Gene expression and cancer classification
- Wnt/β-catenin signaling in development and cancer
Georgetown University
2003-2024
Georgetown University Medical Center
2001-2024
University of Miami
2013-2022
Vince Lombardi Cancer Clinic
1989-2022
Georgetown Lombardi Comprehensive Cancer Center
1996-2022
Memorial Sloan Kettering Cancer Center
1989-2022
Northwestern University
2000-2022
Duke University
2022
Moffitt Cancer Center
2022
Sylvester Comprehensive Cancer Center
2014-2021
ContextRaloxifene hydrochloride is a selective estrogen receptor modulator that has antiestrogenic effects on breast and endometrial tissue estrogenic bone, lipid metabolism, blood clotting.ObjectiveTo determine whether women taking raloxifene have lower risk of invasive cancer.Design SettingThe Multiple Outcomes Raloxifene Evaluation (MORE), multicenter, randomized, double-blind trial, in which or placebo were followed up for median 40 months (SD, 3 years), from 1994 through 1998, at 180...
Background: Overexpression of the erbB-2 protein by breast cancer cells has been suggested to be a predictor response doxorubicin. A retrospective study was designed test this hypothesis. Methods: In National Surgical Adjuvant Breast and Bowel Project protocol B-11, patients with axillary lymph node-positive, hormone receptor-negative were randomly assigned receive either Lphenylalanine mustard plus 5-fluorouracil (PF) or combination L-phenylalanine mustard, 5-fluorouracil, doxorubicin...
Agents targeting programmed death receptor 1 (PD-1) or its ligand (PD-L1) have shown antitumor activity in the treatment of metastatic breast cancer (MBC). The aim this study was to assess avelumab, a PD-L1 inhibitor, patients with MBC.
In order to investigate the prognostic significance of erbB-2 overexpression, immunohistochemical staining for protein was performed on sections from paraffin blocks 292 primary invasive breast cancers obtained women enrolled in National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-06. Positive reaction indicative overexpression observed tumor cells 62 (21%) samples. Women whose were judged have had a significantly worse overall survival (P = .0012) with twice mortality rate...
Abstract BACKGROUND Between 1979–1987, the National Cancer Institute conducted a randomized, prospective study of mastectomy (MT) versus breast conservation therapy (BCT) in treatment patients with early‐stage carcinoma. After median potential follow‐up 18.4 years, authors present updated results. METHODS informed consent was obtained from each patient, 237 evaluable women clinical AJCC Stage I and II carcinoma were enrolled on an institutionally reviewed protocol randomly assigned to...
Abstract Lack of estrogen receptor (ER) and presence vimentin (VIM) associate with poor prognosis in human breast cancer. We have explored the relationships between ER, VIM, invasiveness cancer cell lines. In matrigel outgrowth assay, ER+/VIM‐ (MCF‐7, T47D, ZR‐75‐1), ER‐/VIM‐ (MDA‐MB‐468, SK‐Br‐3) lines were uninvasive, while ER‐/VIM+ (BT549, MDA‐MB‐231, MDA‐MB‐435, MDA‐MB‐436, Hs578T) formed invasive, penetrating colonies. Similarly, significantly more invasive than either or Boyden chamber...
Insulin-like growth factor I (IGF-I) activity has been reported to be produced by several human cancers. Identification of RNAs transcribed from the IGF-I gene complicated detection multiple hybridizing bands on Northern analysis. To determine if any these are gene, we have used a sensitive and specific ribonuclease (RNAse) protection assay for IGF-I. We also studied breast cancer tissue expression using in situ hybridization histochemistry. found no mRNA (zero 11) or colon 9) cell lines;...
The interactions of transformed cells with the surrounding stromal are importance for tumor progression and metastasis. relevance adipocyte-derived factors to breast cancer cell survival growth is well established. However, it remains unknown which specific most critical in this process. Collagen VI abundantly expressed adipocytes. Collagen–/– mice background mouse mammary virus/polyoma virus middle T oncogene (MMTV-PyMT) model demonstrate dramatically reduced rates early hyperplasia primary...
In a retrospective study we determined the relation between estrogen receptors and response rate to cytotoxic chemotherapy in 70 patients with metastatic breast cancer. Thirty-four of 45 low or absent estrogen-receptor values (less than 10 fmol per milligram cytoplasmic protein) had objective responses chemotherapy, whereas only three 25 higher (greater responded (P less 0.0001). There were no statistically significant differences two groups age, menopausal status, disease-free interval,...
Metastasis is facilitated by cancer-associated fibroblasts (CAF) in the tumor microenvironment through mechanisms yet to be elucidated. In this study, we used a size-based microfilter technology developed our group examine whether circulating CAF identified FAP and α-SMA co-expression (cCAF) could distinguished peripheral blood of patients with metastatic breast cancer. pilot study cancer, detected presence cCAFs 30/34 (88%) disease (MET group) 3/13 (23%) localized cancer (LOC long-term...
PURPOSE Mastectomy versus excisional biopsy (lumpectomy) plus radiation for the treatment of stage I and II breast cancer was compared in a prospective randomized study. PATIENTS AND METHODS From 1979 to 1987, 247 women were 237 treated on this All patients received full axillary dissection all node-positive adjuvant chemotherapy with cyclophosphamide doxorubicin. Radiation consisted external-beam therapy whole or without supraclavicular nodal irradiation followed by boost tumor bed. RESULTS...
The X-linked inhibitor of apoptosis (XIAP) is a promising new molecular target for the design novel anticancer drugs aiming at overcoming apoptosis-resistance cancer cells to chemotherapeutic agents and radiation therapy. Recent studies demonstrated that BIR3 domain XIAP where caspase-9 Smac proteins bind an attractive site designing small-molecule inhibitors XIAP. Through computational structure-based screening in-house traditional herbal medicine three-dimensional structure database 8221...