A5069616282- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Advanced Radiotherapy Techniques
- Neuroblastoma Research and Treatments
- Management of metastatic bone disease
- Ocular Oncology and Treatments
- Radiation Therapy and Dosimetry
- Vascular Malformations Diagnosis and Treatment
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related cognitive impairment studies
- Pituitary Gland Disorders and Treatments
- Sarcoma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Neurofibromatosis and Schwannoma Cases
- Testicular diseases and treatments
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Childhood Cancer Survivors' Quality of Life
- Medical Imaging Techniques and Applications
- Ear and Head Tumors
- Lung Cancer Treatments and Mutations
University of Toronto
2016-2025
Princess Margaret Cancer Centre
2016-2025
University Health Network
2016-2025
Hospital for Sick Children
2013-2024
Creative Commons
2024
Toronto Western Hospital
1990-2023
SickKids Foundation
2004-2021
Ontario Institute for Cancer Research
1990-2021
Systems, Applications & Products in Data Processing (Canada)
2021
Deleted Institution
2021
Purpose Anaplastic oligodendrogliomas, pure (AO) and mixed (anaplastic oligoastrocytoma [AOA]), are chemosensitive, especially if codeleted for 1p/19q, but whether patients live longer after chemoradiotherapy is unknown. Patients Methods Eligible with AO/AOA were randomly assigned to procarbazine, lomustine, vincristine (PCV) plus radiotherapy (RT) versus RT alone. The primary end point was overall survival (OS). Results Two hundred ninety-one eligible assigned: 148 PCV 143 RT. For the...
Glioblastoma is associated with a poor prognosis in the elderly. Survival has been shown to increase among patients 70 years of age or younger when temozolomide chemotherapy added standard radiotherapy (60 Gy over period 6 weeks). In elderly patients, more convenient shorter courses are commonly used, but benefit adding course unknown.We conducted trial involving 65 older newly diagnosed glioblastoma. Patients were randomly assigned receive either alone (40 15 fractions) concomitant and...
Patients with 1p/19q codeleted anaplastic oligodendroglial tumors who participated in RTOG (Radiation Therapy Oncology Group) 9402 lived much longer after chemoradiotherapy (CRT) than radiation therapy (RT) alone. However, some patients noncodeleted also benefited from CRT; survival curves separated the median had been reached, and significantly more ≥ 10 years CRT RT. Thus, status may not identify all responders to CRT.Using trial data, we inquired whether an IDH mutation or germ-line...
Purpose To examine the impact of radiation (ie, craniospinal irradiation [CSR] dose and boost volume) complications hydrocephalus other neurologic complications, including mutism) on patterns change in intellectual functioning medulloblastoma survivors. Patients Methods We conducted a retrospective review 113 patients treated for between 1983 2011 who were seen neuropsychological assessment, longitudinal follow-up function. with either standard-dose CSR posterior fossa (PF) (n = 51), plus...
Proton radiotherapy (PRT) may lessen the neuropsychological risk traditionally associated with cranial for treatment of pediatric brain tumors by reducing dose to normal tissue compared that photon (XRT). We examined change in intellectual scores over time patients medulloblastoma treated craniospinal PRT versus XRT.Intelligence test were obtained a sample between 2007 and 2018 on same protocols differed only modality (PRT v XRT). Growth curve analyses since diagnosis groups.Longitudinal...
Many case reports in the literature associate cranial radiation therapy with development of brain tumors. Quantitation risk second tumors after irradiation childhood is available, but it seldom reported for those treated by as adults.A retrospective review was made 367 patient records registered at Princess Margaret Hospital a diagnosis pituitary adenoma from 1972 to 1986. Three hundred five patients megavoltage form basis this report. Second were identified and histories described. The...
<b>Objective: </b> To describe the demographics, diagnostic details, therapeutic management, and outcome in patients with primary CNS lymphoma (PCNSL) ocular involvement. <b>Methods: A retrospective study of 221 was assembled from 16 centers seven countries. Only HIV-negative, immunocompetent brain were included; none had systemic lymphoma. <b>Results: Median age at diagnosis 60. Fifty-seven percent women. Eastern Cooperative Oncology Group performance status 2. Ocular disturbance...
Treatment for medulloblastoma during childhood impairs neurocognitive function in survivors. While those diagnosed at younger ages are most vulnerable, little is known about the long-term neurocognitive, functional, and physical outcomes survivors as they approach middle age. In this retrospective cohort study, we assessed 20 adults who were treated with surgery radiotherapy (median age assessment, 21.9 years [range, 18–47 years]; median time since diagnosis, 15.5 6.5–42.2 years]). Nine...
BACKGROUND The determinants of outcomes for adult survivors pediatric low‐grade glioma (PLGG) are largely unknown. METHODS This study collected population‐based follow‐up information all PLGG patients diagnosed in Ontario, Canada from 1985 to 2012 (n = 1202) and determined factors affecting survival. impact upfront radiation treatment on overall survival (OS) was a cohort Ontario an independent reference the Surveillance, Epidemiology, End Results database. RESULTS At median 12.73 years...