A5010784905- Lymphoma Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Lung Cancer Treatments and Mutations
- Radiation Dose and Imaging
- Advanced Radiotherapy Techniques
- Ovarian cancer diagnosis and treatment
- BRCA gene mutations in cancer
- Patient-Provider Communication in Healthcare
- Multiple and Secondary Primary Cancers
- Thyroid and Parathyroid Surgery
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Glioma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cervical Cancer and HPV Research
- Nonmelanoma Skin Cancer Studies
- Medical Imaging Techniques and Applications
- Head and Neck Anomalies
- Colorectal and Anal Carcinomas
- Vascular Tumors and Angiosarcomas
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
University Health Network
2016-2025
Princess Margaret Cancer Centre
2016-2025
University of Toronto
2014-2023
Princess Margaret Hospital
1999-2023
The Alfred Hospital
2018
The University of Adelaide
2018
Royal Adelaide Hospital
2018
Peter MacCallum Cancer Centre
2018
St. Michael's Hospital
2012
Women's College Hospital
2012
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a distinct with unique clinicopathologic features. We report the clinical outcome stage I and II MALT treated involved field radiation therapy (RT).From 1989 to 2000, 103 patients IE IIE disease were referred. Their median age was 60 years, 2:1 female predominance. Presenting sites stomach (17 patients), orbital adnexa (31 salivary glands (24 thyroid gland (13 other (18 patients). Ninety-three...
BACKGROUND The aim of this study was to determine the prognostic factors for local failure and cause specific survival in differentiated thyroid carcinoma impact surgery, radioiodine, external beam radiation therapy (RT) when used as part initial management. METHODS authors reviewed records 382 patients with (papillary, 262; follicular, 120) managed at Princess Margaret Hospital (PMH) between 1958 1985. There were 220 Stage I or II, 102 III, 33 IV disease (according 1987 staging criteria...
Differentiated thyroid cancer has a good prognosis and only rarely presents with distant metastasis at diagnosis. The clinical outcome of this presentation was assessed respect to survival factors that may determine prognosis.A retrospective review undertaken patients stage M1 differentiated (n = 49), referred from 1980-2000 single institution.The median age 68 (range, 17-90), 69% females. initial site(s) were lung only, 45%, bone 39%, other site, 4%, multiple sites, 12%.papillary, 51%,...
Records of 73 patients with medullary thyroid cancer were reviewed to assess prognostic factors and the role external beam radiation therapy. Patients treated between 1954 1992. The median age was 49 years (range 15–85), M:F ratio 1.6:1, follow-up 7.9 years. (2.5–34.6). primary tumor size <1 cm in 10%, 1–4 53%, >4 37%. Multifocality noted 32%, 23% had metastasis at presentation. Eight presented inoperable tumors, 40% gross, 37% microscopic residual disease postthyroidectomy. Extraglandular...
Many case reports in the literature associate cranial radiation therapy with development of brain tumors. Quantitation risk second tumors after irradiation childhood is available, but it seldom reported for those treated by as adults.A retrospective review was made 367 patient records registered at Princess Margaret Hospital a diagnosis pituitary adenoma from 1972 to 1986. Three hundred five patients megavoltage form basis this report. Second were identified and histories described. The...
BACKGROUND There is no consensus regarding the comparison of staging classifications. Recently, numerous classifications for thyroid carcinoma have been described. This study was performed to evaluate relative discriminating ability these different systems. METHODS A literature review conducted identify available used carcinoma. To compare various classifications, cause specific survival data from a retrospective 382 patients with papillary and follicular treated at Princess Margaret...
Purpose To describe the demographic and tumor related characteristics outcomes for patients with primary T-cell CNS lymphoma (TPCNSL). Patients Methods A retrospective series of TPCNSL was compiled from twelve cancer centers in seven countries. Results We identified 45 a median age 60 years (range, 3 to 84 years). Twenty (44%) had Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 or 1. Twenty-six (58%) involvement cerebral hemisphere sixteen (36%) lesions deeper sites...
This study was conducted to evaluate the long-term outcomes in patients with stage IE and IIE mucosa-associated lymphoid tissue (MALT) lymphomas treated involved field radiotherapy (RT).Between 1989 2004, 192 I II MALT were treated. The report focuses on 167 who received RT. median age of 58 years a female predominance (2:1). Presenting sites as follows: orbital adnexa 71 patients, salivary glands 28 stomach 25 thyroid 21 other 22 patients. dose nonorbital 30 grays (Gy) (range, 17.5-35 Gy)...
Abstract Background Solitary plasmacytoma (SP) of the bone is a rare plasma-cell neoplasm. There are no conclusive data in literature on optimal radiation therapy (RT) dose SP. Therefore, this large retrospective study, we wanted to assess outcome, prognostic factors, and RT patients with Methods Data from 206 SP without evidence multiple myeloma (MM) were collected. Histopathological diagnosis was obtained for all patients. The majority (n = 169) received alone; 32 chemotherapy RT, 5...
To assess the prognostic factors and role of radioactive iodine (RAI) external beam radiotherapy (RT) in patients with differentiated thyroid cancer.A retrospective review 729 treated between 1958 1998. The median follow-up was 11.3 years (range 0.3-39.8 years). Primary outcomes included time to cause-specific survival local-regional relapse. Baseline treatment variables were assessed for statistical significance using Cox proportional hazards model.The 10-year (CSS) 87.3% relapse-free rate...
Age- and sex-specific estimates of the rate cardiac morbidity among Hodgkin lymphoma (HL) patients treated with doxorubicin-based chemotherapy radiation therapy (RT) are scarce. We evaluated risk hospital admission for disease in 615 HL patients, adjusting age, sex, treatment, factors competing causes death. Compared general population, was highest both doxorubicin mediastinal RT (HR = 2.77, p < 0.0001). Mediastinal without also significantly increased 1.82, 0.038). For females males plus at...
Head and neck solitary extramedullary plasmacytomas are rare plasma cell neoplasms. Literature review reveals only small numbers of reports. The objective was to our experience with treating patients this neoplasm.A retrospective chart between 1960 2000 performed. Sixty-eight head were included.The sinonasal tract the most common site. Thirty-nine treated radiation, 8 surgery, 14 surgery 3 chemoradiation. Median follow-up years. 5-year local recurrence-free rate (LRFR) 81%. There a trend...
Follicular lymphoma (FL) is curable by involved-field radiotherapy (IFRT) in < 50% of patients with stage I to II disease. We hypothesized that adding systemic therapy IFRT would improve long-term progression-free survival (PFS).A multicenter randomized controlled trial enrolled low-grade FL after staging computed tomography scans and bone marrow biopsies. 18F-labeled fluorodeoxyglucose-positron emission (PET) was not mandatory. Patients were randomly assigned either arm A (30 Gy alone) or B...
Abstract Derived from our original nomogram study by using the risk variables multivariable analyses in derivation cohort of 1383 patients with extranodal NK/T-cell lymphoma, nasal-type (ENKTCL) who were mostly treated anthracycline-based chemotherapy, we propose an easily used nomogram-revised index (NRI), validated it and compared Ann Arbor staging, International Prognostic Index (IPI), Korean (KPI), prognostic natural killer lymphoma (PINK) for overall survival (OS) prediction examining...