A5044593939- Glioma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Brain Metastases and Treatment
- Childhood Cancer Survivors' Quality of Life
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Management of metastatic bone disease
- Neuroblastoma Research and Treatments
- Medical Imaging Techniques and Applications
- Oral and Maxillofacial Pathology
- Radiomics and Machine Learning in Medical Imaging
- Chromatin Remodeling and Cancer
- Cancer-related cognitive impairment studies
- Ocular Oncology and Treatments
- Acute Lymphoblastic Leukemia research
- Ear and Head Tumors
- Advances in Oncology and Radiotherapy
- Hematopoietic Stem Cell Transplantation
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Radiation Dose and Imaging
- Colorectal and Anal Carcinomas
Mayo Clinic
2018-2025
Mayo Clinic in Arizona
2017-2024
Radiation Oncology Associates
2012-2024
Institute of Medical Sciences
2013-2024
Maulana Azad Medical College
2009-2023
WinnMed
2018-2023
The University of Texas MD Anderson Cancer Center
2012-2022
Baylor College of Medicine
2011-2021
University of Arkansas for Medical Sciences
2021
Universitätsklinikum Erlangen
2021
Purpose Radiotherapy with concomitant and adjuvant temozolomide is the standard of care for newly diagnosed glioblastoma (GBM). O 6 -methylguanine-DNA methyltransferase (MGMT) methylation status may be an important determinant treatment response. Dose-dense (DD) results in prolonged depletion MGMT blood mononuclear cells possibly tumor. This trial tested whether DD improves overall survival (OS) or progression-free (PFS) patients GBM. Patients Methods phase III enrolled older than age 18...
Proton radiotherapy (PRT) may lessen the neuropsychological risk traditionally associated with cranial for treatment of pediatric brain tumors by reducing dose to normal tissue compared that photon (XRT). We examined change in intellectual scores over time patients medulloblastoma treated craniospinal PRT versus XRT.Intelligence test were obtained a sample between 2007 and 2018 on same protocols differed only modality (PRT v XRT). Growth curve analyses since diagnosis groups.Longitudinal...
YKL-40 is a secreted protein that has been reported to be overexpressed in epithelial cancers and gliomas, although its function unknown. Previous data smaller sample set suggested was marker associated with poorer clinical outcome genetically defined subgroup of glioblastoma. Here we test these findings larger series patients glioblastoma, particular, determine if tumor expression radiation response.Patients (n=147) subtotal resections were studied for imaging-assessed changes size serial...
Compared with photon radiation (XRT), proton beam therapy (PBRT) reduces dose to normal tissues, which may lead better neurocognitive outcomes. We compared change in intelligence quotient (IQ) over time pediatric patients brain tumors treated PBRT versus XRT.IQ scores were available for 150 (60 had received XRT, 90 PBRT). Linear mixed models examined IQ since (RT) by RT group, controlling demographic/clinical characteristics. Craniospinal and focal subgroups also examined.In the no was...
Object Despite a favorable outcome for most patients with WHO Grade I meningiomas, subset of these will have recurrent or progressive disease that advances to higher grade and requires increasingly aggressive therapy. The goal this study was identify clinical characteristics associated the recurrence benign meningiomas their acceleration atypical malignant histological types. Methods Records 216 I, II, III meningioma were initially treated between 1965 2001 retrospectively reviewed. Median...
Abstract BACKGROUND Solitary brain metastases occur in about 50% of patients with from nonsmall cell lung cancer (NSCLC). The standard care is surgical resection solitary metastases, or stereotactic radiosurgery (SRS) plus whole radiation therapy (WBRT). However, the optimal treatment for primary site newly diagnosed NSCLC a metastasis not well defined. goal was to distinguish which might benefit aggressive their whose treated surgery SRS. METHODS cases 84 presenting and December 1993...
For many decades, the standard of care radiotherapy regimen for medulloblastoma has been photon (megavoltage x-rays) craniospinal irradiation (CSI). The late effects associated with CSI are well-documented in literature and in-part attributed to unwanted dose healthy tissue. Recently, there is growing interest using proton therapy pediatric adolescent patients reduce this undesirable dose. Previous comparisons target non-target organs from conventional passively scattered have limited small...
Pediatric patients who received radiation therapy are at risk of developing side effects such as radiogenic second cancer. We compared proton and photon therapies in terms the predicted cancers for a 4 year old medulloblastoma patient receiving craniospinal irradiation (CSI). Two CSI treatment plans with 23.4 Gy or (RBE) prescribed dose were computed: three-field 6 MV plan four-field plan. The primary doses both determined using commercial planning system. Stray from Monte Carlo simulations,...
Retrospective comparative cohort series.The aim of this study was to evaluate patients treated with proton therapy for chordoma and chondrosarcoma the spine in postoperative setting report local control, relapse-free, overall survival outcomes.Margin-negative resection spinal chordomas chondrosarcomas can be challenging, so adjuvant radiotherapy is often recommended. However, delivery adequate complicated by relative radioresistance these tumors, necessitating high doses, as well proximity...
Diffuse intrinsic pontine gliomas (DIPGs) are highly aggressive tumors and have a poor prognosis. Nearly all patients experience disease progression after definitive treatment, accompanied by severe neurologic deficits morbidity. Here, we report series of treated with reirradiation for palliation symptoms.Six received progressive DIPG at MD Anderson Cancer Center from 2007 to 2009. Progression initial chemoradiation salvage chemotherapy had been confirmed clinically magnetic resonance...
Chemoradiation, followed by adjuvant temozolomide, is the standard treatment for newly diagnosed glioblastoma. Adding other active agents may enhance efficacy. The primary objective of this factorial phase II study was to determine if one 3 potential chemotherapy added dose-dense temozolomide (ddTMZ) improves progression-free survival (PFS) patients with A prior I trial established safety combining ddTMZ isotretinoin, celecoxib, and/or thalidomide. Adults good performance status and no...
Proton radiotherapy (PRT) reduces the volume of normal tissue receiving radiation dose, which may lead to better neurocognitive outcomes. We examined change in scores over time pediatric brain tumor patients treated with proton craniospinal irradiation (CSI), focal RT, or surgery only.Patients received annual evaluations for up 6 years. Full Scale IQ (FSIQ), Verbal Comprehension Index (VCI), Perceptual Reasoning (PRI), Working Memory (WMI), and Processing Speed (PSI) scores. General linear...
This study aimed to determine whether proton craniospinal irradiation (CSI) decreased the dose normal tissue and resulted in less toxicity than photon CSI for adult patients.
Intracranial hemangiopericytoma (HPC) is a rare malignancy for which treatment recommendations vary.We sought to characterize outcomes of HPC patients treated with postoperative external beam radiotherapy (PORT).A retrospective analysis was conducted using the Surveillance, Epidemiology and End Results (SEER) Program US National Cancer Institute. We identified intracranial who underwent surgery alone or PORT.We 88 diagnosis between 1982 2009 PORT. The majority were female (53%) white (84%)...