A5003515749- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Brain Metastases and Treatment
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- CNS Lymphoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Advanced MRI Techniques and Applications
- Lung Cancer Research Studies
- Meningioma and schwannoma management
- Lung Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Radiation Dose and Imaging
- Ear and Head Tumors
- Cancer, Hypoxia, and Metabolism
- Management of metastatic bone disease
- Advances in Oncology and Radiotherapy
- MRI in cancer diagnosis
- Viral-associated cancers and disorders
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
Medical College of Wisconsin
2016-2025
Froedtert Hospital
2015-2025
University of North Carolina at Charlotte
2023-2024
National Patient Safety Foundation
2022
Thomas Jefferson University
2006-2019
Milwaukee VA Medical Center
2017-2018
Lutheran Hospital
2018
NRG Oncology
2016
Cleveland Clinic
2008-2016
Centre Hospitalier de l’Université de Montréal
2016
Despite the use of resection and postoperative radiotherapy, high-risk squamous-cell carcinoma head neck frequently recurs in original tumor bed. We tested hypothesis that concurrent administration cisplatin radiotherapy would improve rate local regional control.Between September 9, 1995, April 28, 2000, 459 patients were enrolled. After undergoing total all visible palpable disease, 231 randomly assigned to receive alone (60 66 Gy 30 33 fractions over a period 6 6.6 weeks) 228 identical...
Purpose Radiotherapy with concomitant and adjuvant temozolomide is the standard of care for newly diagnosed glioblastoma (GBM). O 6 -methylguanine-DNA methyltransferase (MGMT) methylation status may be an important determinant treatment response. Dose-dense (DD) results in prolonged depletion MGMT blood mononuclear cells possibly tumor. This trial tested whether DD improves overall survival (OS) or progression-free (PFS) patients GBM. Patients Methods phase III enrolled older than age 18...
Grade 2 gliomas occur most commonly in young adults and cause progressive neurologic deterioration premature death. Early results of this trial showed that treatment with procarbazine, lomustine (also called CCNU), vincristine after radiation therapy at the time initial diagnosis resulted longer progression-free survival, but not overall than alone. We now report long-term results.We included patients grade astrocytoma, oligoastrocytoma, or oligodendroglioma who were younger 40 years age had...
PURPOSE: Primary CNS lymphoma (PCNSL) is an aggressive primary brain tumor. Cranial irradiation alone rarely results in long-term disease control or prolonged survival. We prospectively studied the use of combination chemotherapy plus cranial newly diagnosed patients with PCNSL. PATIENTS AND METHODS: enrolled 102 diagnosed, immunocompetent PCNSL; 98 were assessable. Patients first received five cycles methotrexate 2.5 g/m 2 , vincristine, procarbazine, and intraventricular (12 mg)....
The purpose of this study was to analyze prognostic factors for patients with newly diagnosed primary CNS lymphoma (PCNSL) in order establish a predictive model that could be applied the care and design prospective clinical trials.Three hundred thirty-eight consecutive PCNSL seen at Memorial Sloan-Kettering Cancer Center (MSKCC; New York, NY) between 1983 2003 were analyzed. Standard univariate multivariate analyses performed. In addition, formal cut point analysis used determine most...
Abstract Background. Our objectives were to determine the incidence of acute and late toxicities estimate 2‐year overall survival for patients treated with reirradiation chemotherapy unresectable squamous cell carcinoma head neck (SCCHN). Methods. Patients recurrent or a second primary arising in previously irradiated field eligible. Four weekly cycles 5‐fluorouracil 300 mg/m 2 IV bolus hydroxyurea 1.5 g by mouth used 60 Gy at twice‐daily fractions. Toxicity was scored according Radiation...
NRG Oncology/RTOG 9802 (ClinicalTrials.gov Identifier: NCT00003375) is a practice-changing study for patients with WHO low-grade glioma (LGG, grade II), as it was the first to demonstrate survival benefit of adjuvant chemoradiotherapy over radiotherapy. This post hoc sought determine prognostic and predictive impact WHO-defined molecular subgroups corresponding alterations within 9802.IDH1/2 mutations were determined by immunohistochemistry and/or deep sequencing. A custom Ion AmpliSeq panel...
PURPOSE This study was a prospective phase I/II trial performed by the Radiation Therapy Oncology Group (RTOG) to test tolerance and efficacy of preirradiation cyclophosphamide, doxorubicin, vincristine, dexamethasone (CHOD) chemotherapy followed large-volume, high-dose brain radiation therapy (RT) for patients with primary CNS lymphoma (PCNSL). PATIENTS AND METHODS Fifty-four (52 assessable) human immunodeficiency virus (HIV)-negative PCNSL were entered on received two (n = 20) or three 32)...
To compare dynamic gadolinium-enhanced T1-weighted magnetic resonance (MR) imaging with nonenhanced and T2-weighted MR thin-section computed tomography (CT) for the demonstration of osteoid osteomas.The images 11 patients pathologically proven osteomas who underwent imaging, CT were retrospectively reviewed. Images obtained all three techniques scored conspicuity osteoma relative to surrounding bone. Time-enhancement curves generated from signal intensity measurements these lesions adjacent...
The initial report of NRG Oncology/Radiation Therapy Oncology Group (RTOG) 0424 demonstrated a 3-year overall survival benefit with the addition temozolomide to radiotherapy compared historical control. However, an important end point trial-evaluation association between O6-methylgaunine-DNA-methyltransferase (MGMT) promoter methylation and outcomes-was not previously reported.To examine proportion patients in Oncology/RTOG MGMT its outcomes.Specimens collected were analyzed after trial...
This study investigated the treatment of primary CNS lymphoma with methotrexate, temozolomide (TMZ), and rituximab, followed by hyperfractionated whole-brain radiotherapy (hWBRT) subsequent TMZ. The phase I end point was maximum tolerated dose II 2-year overall survival (OS) rate. Secondary points were preirradiation response rates, progression-free (PFS), neurologic toxicities, quality life.The increased TMZ doses from 100 to 150 200 mg/m(2). Patients treated rituximab 375 mg/m(2) 3 days...
Purpose: MR-guided Radiation Therapy (MRgRT) allows for high-precision radiotherapy under real-time MR visualization. This enables margin reduction and subsequent dose escalation which may lead to higher tumor control less toxicity. The Unity MR-linac (Elekta AB, Stockholm, Sweden) integrates a linear accelerator with 1.5T diagnostic quality MRI an online adaptive workflow. A prospective international registry was established facilitate the evidence-based implementation of into clinical...
American College of Radiology and Society for Radiation Oncology Practice Guideline the Performance Stereotactic Radiosurgery (SRS). SRS is a safe efficacious treatment option variety benign malignant disorders involving intracranial structures selected extracranial lesions. involves high dose ionizing radiation with degree precision spatial accuracy. A quality program requires multidisciplinary team involved in patient management. Organization, appropriate staffing, careful adherence to...
In this report, we describe our implementation and initial clinical experience using 4D-MRI driven MR-guided online adaptive radiotherapy (MRgOART) for abdominal stereotactic body (SBRT) on the Elekta Unity MR-Linac.Eleven patients with malignancies were treated free-breathing SBRT in three to five fractions a 1.5 T MR-Linac. Online plans generated Adapt-To-Position (ATP) or Adapt-To-Shape (ATS) workflows based motion averaged mid-position images derived from pre-beam 4D-MRI. A high...
Prospective quality metrics for neck dissection have not been established patients with head and squamous cell carcinoma. The purpose of this study was to investigate the association between lymph node counts from dissection, local-regional recurrence, overall survival.The number nodes counted in treated 2 NRG Oncology trials (Radiation Therapy Group [RTOG] 9501 RTOG 0234) evaluated its prognostic impact on survival a multivariate Cox model adjusted demographic, tumor, data stratified by...
PURPOSE: Motexafin gadolinium is a redox mediator that selectively targets tumor cells, detectable by magnetic resonance imaging (MRI), and enhances the effect of radiation therapy. This lead-in phase to randomized trial served evaluate radiologic, neurocognitive, neurologic progression end points safety radiologic response motexafin administered concurrently with 30 Gy in 10-fraction whole-brain therapy for treatment brain metastases. PATIENTS AND METHODS: (5.0 mg/kg/d 10 days) was before...