A5078807086- Breast Cancer Treatment Studies
- Advanced Radiotherapy Techniques
- Global Cancer Incidence and Screening
- Cancer survivorship and care
- Advances in Oncology and Radiotherapy
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Chemotherapy-induced cardiotoxicity and mitigation
- Effects of Radiation Exposure
- Prostate Cancer Diagnosis and Treatment
- Ethics in Clinical Research
- Economic and Financial Impacts of Cancer
- Cancer Risks and Factors
- Breast Implant and Reconstruction
- Advanced X-ray and CT Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Breast Lesions and Carcinomas
- Palliative Care and End-of-Life Issues
- Childhood Cancer Survivors' Quality of Life
- Cancer Treatment and Pharmacology
- Appendicitis Diagnosis and Management
- Nonmelanoma Skin Cancer Studies
- Lymphatic System and Diseases
- Head and Neck Cancer Studies
- Complementary and Alternative Medicine Studies
Henry Ford Health System
2016-2025
Michigan State University
2024-2025
Henry Ford Health + Michigan State University Health Sciences
2024
Henry Ford Hospital
2014-2024
University of Pittsburgh
2024
William & Mary
2024
The Barbara Ann Karmanos Cancer Institute
2018-2023
University of Edinburgh
2023
Derriford Hospital
2023
Royal Devon and Exeter Hospital
2020-2022
The Radiation Therapy Oncology Group 9804 study identified good-risk patients with ductal carcinoma in situ (DCIS), a breast cancer diagnosis found frequently mammographically detected cancers, to test the benefit of radiotherapy (RT) after breast-conserving surgery compared observation.This prospective randomized trial (1998 2006) women low- or intermediate-grade DCIS, measuring less than 2.5 cm margins ≥ 3 mm, RT observation surgery. was designed for 1,790 but closed early because lower...
PURPOSE The aim of this joint guideline is to provide evidence-based recommendations practicing physicians and other health care providers on integrative approaches managing pain in patients with cancer. METHODS Society for Integrative Oncology ASCO convened an expert panel oncology, medical radiation surgical palliative social sciences, mind-body medicine, nursing, patient advocacy representatives. literature search included systematic reviews, meta-analyses, randomized controlled trials...
Vasomotor symptoms are common adverse effects of antiestrogen hormone treatment in conventional breast cancer care. Hormone replacement therapy is contraindicated patients with cancer. Venlafaxine (Effexor), the choice for these symptoms, has numerous effects. Recent studies suggest acupuncture may be effective reducing vasomotor menopausal women. This randomized controlled trial tested whether reduces and produces fewer than venlafaxine.Fifty were randomly assigned to receive 12 weeks (n =...
The initial report of NRG Oncology/Radiation Therapy Oncology Group (RTOG) 0424 demonstrated a 3-year overall survival benefit with the addition temozolomide to radiotherapy compared historical control. However, an important end point trial-evaluation association between O6-methylgaunine-DNA-methyltransferase (MGMT) promoter methylation and outcomes-was not previously reported.To examine proportion patients in Oncology/RTOG MGMT its outcomes.Specimens collected were analyzed after trial...
Randomized trials have established the long-term safety and efficacy of hypofractionated whole-breast radiotherapy, but little is known about acute toxic effects experienced by patients treated with hypofractionation as compared conventional fractionation, particularly in real-world settings from patient's own perspective.To evaluate prospectively collected data on patient-reported outcomes a cohort varying radiation fractionation schemes practices collaborating Michigan Radiation Oncology...
Purpose Radiation dose to cardiac substructures is related radiation‐induced heart disease. However, are not considered in radiation therapy planning (RTP) due poor visualization on CT. Therefore, we developed a novel deep learning (DL) pipeline leveraging MRI’s soft tissue contrast coupled with CT for state‐of‐the‐art substructure segmentation requiring single, non‐contrast input. Materials/methods Thirty‐two left‐sided whole‐breast cancer patients underwent T2 MRI and CT‐simulation. A...
<h3>Importance</h3> Understanding whether physicians accurately detect symptoms in patients with breast cancer is important because recognition of facilitates supportive care, and clinical trials often rely on physician assessments using Common Toxicity Criteria for Adverse Events (CTCAE). <h3>Objective</h3> To compare the patient-reported outcomes (PROs) who received radiotherapy from January 1, 2012, to March 31, 2020, physicians' CTCAE assess underrecognition symptoms. <h3>Design,...
Triple-negative breast cancer (TNBC) is a highly aggressive form of subtype often treated with radiotherapy (RT). Due to its intrinsic heterogeneity and lack effective targets, it crucial identify novel molecular targets that would increase RT efficacy. Here we demonstrate the role BUB1 (cell cycle Ser/Thr kinase) in TNBC radioresistance offer strategy improve treatment. Gene expression analysis was performed look at genes upregulated patient samples compared other subtypes. Cell...
Racial and ethnic diversity has historically been difficult to achieve in National Cancer Institute-sponsored clinical trials, even while as many 80% of those trials have faced difficulty meeting overall recruitment targets. In an attempt address these issues, NRG Oncology recently convened a comprehensive workshop titled "Clinical Trials Enrollment: Challenges Opportunities." Discussants at the included representatives three legacy groups (ie, Gynecologic Group, Surgical Adjuvant Breast...
To our knowledge, NRG/RTOG 9804 is the only randomized trial to assess impact of whole breast irradiation (radiation therapy [RT]) versus observation (OBS) in women with good-risk ductal carcinoma situ (DCIS), following lumpectomy. Long-term results focusing on ipsilateral recurrence (IBR), primary outcome, are presented here.Eligible patients underwent lumpectomy for DCIS that was mammogram detected, size ≤ 2.5 cm, final margins ≥ 3 mm, and low or intermediate nuclear grade. Consented were...
BUB1 is overexpressed in most human solid cancers including breast cancer. Higher levels are associated with poor prognosis especially patients triple-negative cancer (TNBC). Women TNBC often develop resistance to chemotherapy and radiotherapy, which still the mainstay of treatment for TNBC. Our previous studies demonstrated that kinase inhibitor (BAY1816032) reduced tumor cell proliferation significantly enhanced radiotherapy efficacy In this study, we evaluated effectiveness BAY1816032 a...
BUB1 is overexpressed in most human solid cancers, including breast cancer. Higher levels are associated with a poor prognosis, especially patients triple-negative cancer (TNBC). Women TNBC often develop resistance to chemotherapy and radiotherapy, which still the mainstay of treatment for TNBC. Our previous studies demonstrated that kinase inhibitor (BAY1816032) reduced tumor cell proliferation significantly enhanced radiotherapy efficacy In this study, we evaluated effectiveness BAY1816032...
Traditional medicine is widely used in sub-Saharan Africa, particularly Ghana, where it commonly integrated with modern orthodox medicine. This study examines the barriers that delay pursuit of medical care for prostate cancer (PCa) Ghana's Central region, a blend traditional and exists. The preference indigenous often results late-stage presentations PCa, adversely affecting patient outcomes. prospective cross-sectional was conducted from July to December 2022 at Cape Coast Teaching...
Heart failure (HF) due to cardiotoxicity is a leading non-cancer-related cause of morbidity and mortality in cancer survivors. Cardiac rehabilitation (CR) improves cardiorespiratory fitness (CRF) reduces patients with HF, but little known about its effects on the population. The objective this study was determine whether participation CR CRF undergoing treatment either doxorubicin or trastuzumab who exhibit markers subclinical cardiotoxicity.Female (n = 28: breast, n 1: leiomyosarcoma)...