A5077260727- Chromatin Remodeling and Cancer
- Glioma Diagnosis and Treatment
- Mechanisms of cancer metastasis
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Brain Metastases and Treatment
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Endoplasmic Reticulum Stress and Disease
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- RNA regulation and disease
- Advanced Radiotherapy Techniques
- Marine and environmental studies
- Neuroblastoma Research and Treatments
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Retinal Diseases and Treatments
The Ohio State University
2016-2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2012-2023
Neurosciences Institute
2023
University of Alabama at Birmingham
2022
Neurological Research Institute
2021
The Ohio State University Wexner Medical Center
2015-2019
Digital Health Cooperative Research Centre
2019
Radiation Oncology Associates
2019
Digital China Health (China)
2019
University of California, San Francisco
2017
Grade 2 gliomas occur most commonly in young adults and cause progressive neurologic deterioration premature death. Early results of this trial showed that treatment with procarbazine, lomustine (also called CCNU), vincristine after radiation therapy at the time initial diagnosis resulted longer progression-free survival, but not overall than alone. We now report long-term results.We included patients grade astrocytoma, oligoastrocytoma, or oligodendroglioma who were younger 40 years age had...
NRG Oncology/RTOG 9802 (ClinicalTrials.gov Identifier: NCT00003375) is a practice-changing study for patients with WHO low-grade glioma (LGG, grade II), as it was the first to demonstrate survival benefit of adjuvant chemoradiotherapy over radiotherapy. This post hoc sought determine prognostic and predictive impact WHO-defined molecular subgroups corresponding alterations within 9802.IDH1/2 mutations were determined by immunohistochemistry and/or deep sequencing. A custom Ion AmpliSeq panel...
Abstract Glioblastoma is the most common and aggressive histologic subtype of brain cancer with poor outcomes limited treatment options. Here, we report selective overexpression protein arginine methyltransferase PRMT5 as a novel candidate theranostic target in this disease. silences transcription regulatory genes by catalyzing symmetric dimethylation residues on histone tails. patient-derived primary tumors cell lines correlated line growth rate inversely overall patient survival. Genetic...
The initial report of NRG Oncology/Radiation Therapy Oncology Group (RTOG) 0424 demonstrated a 3-year overall survival benefit with the addition temozolomide to radiotherapy compared historical control. However, an important end point trial-evaluation association between O6-methylgaunine-DNA-methyltransferase (MGMT) promoter methylation and outcomes-was not previously reported.To examine proportion patients in Oncology/RTOG MGMT its outcomes.Specimens collected were analyzed after trial...
Identification of predictive biomarkers is critically needed to improve selection patients who derive the most benefit from platinum-based chemotherapy. We hypothesized that decreased expression SMARCA4/BRG1, a known regulator transcription and DNA repair, novel biomarker increased sensitivity adjuvant therapies in non-small cell lung cancer (NSCLC).The prognostic value was tested using gene-expression microarray Director's Challenge Lung Study (n = 440). The significance SMARCA4 determined...
<h3>Importance</h3> There is a need for more refined, molecularly based classification model glioblastoma (GBM) in the temozolomide era. <h3>Objective</h3> To refine existing clinically recursive partitioning analysis (RPA) by incorporating molecular variables. <h3>Design, Setting, and Participants</h3> NRG Oncology RTOG 0525 specimens (n = 452) were analyzed protein biomarkers representing key pathways GBM quantitative microscopy-based approach with semiquantitative immunohistochemical...
The primary objective of this study was to compare the overall survival (OS) patients with anaplastic astrocytoma (AA) treated radiotherapy (RT) and either temozolomide (TMZ) or a nitrosourea (NU). Secondary endpoints were time tumor progression (TTP), toxicity, effect IDH1 mutation status on clinical outcome.
Multiple studies have reported favorable outcomes for stereotactic radiosurgery (SRS) in the treatment of limited brain metastases. An obstacle SRS management numerous metastases is longer time using traditional radiosurgery. Single-isocenter multitarget (SIMT) a novel technique that permits rapid therapy delivery to multiple There lack clinical evidence regarding its efficacy and safety. We report patients treated with this technique.We reviewed records intact or resected 1 5 fractions SIMT...
MicroRNAs (miRNAs) are regulatory RNAs frequently dysregulated in disease and following cellular stress. Investigators have described changes miR-15b expression exposure to several stress-inducing anticancer agents, including ionizing radiation (IR), etoposide, hydrogen peroxide. However, the role for as a mediator of injury organs such lung has yet be explored. In this study, we examined patterns well its potential DNA damage repair setting IR exposure. We showed that is up-regulated dose-...
Technologic advances have enabled the comprehensive analysis of genetic perturbations in non-small-cell lung cancer (NSCLC); however, African Americans often been underrepresented these studies. This ethnic group has higher incidence and mortality rates, some studies suggested a lower epidermal growth factor receptor mutations. Herein, we report most in-depth molecular profile NSCLC to date.A custom panel was designed cover coding regions 81 NSCLC-related genes 40 ancestry-informative...
Abstract Cancer stem cells (CSCs), representing the root of many solid tumors including ovarian cancer, have been implicated in disease recurrence, metastasis, and therapeutic resistance. Our previous study has demonstrated that CSC subpopulation cancer can be limited by DNA damage-binding protein 2 (DDB2). Here, we maintained via cell dedifferentiation, DDB2 is able to suppress this non-CSC-to-CSC conversion repression ALDH1A1 transcription. Mechanistically, binds gene promoter,...
Introduction The subventricular zone (SVZ) in the brain is associated with gliomagenesis and resistance to treatment glioblastoma. In this study, we investigate prognostic role biological characteristics of involvement Methods We analyzed T1-weighted, gadolinium-enhanced MR images a retrospective cohort 647 primary glioblastoma patients diagnosed between 2005–2013, performed multivariable Cox regression analysis adjust effect SVZ for clinical patient- tumor-related factors. Protein...
Lipid dyshomeostasis and tau pathology are present in frontotemporal lobar degeneration (FTLD) Alzheimer's disease (AD). However, the relationship between lipid remains unclear. We report that GRAM Domain Containing 1B (GRAMD1B), a nonvesicular cholesterol transporter, is increased excitatory neurons of human neural organoids (HNOs) with MAPT R406W mutation. Human FTLD, AD cases, PS19 mice also have GRAMD1B expression. show overexpression increases levels free cholesterol, droplets, impairs...
To develop a microRNA (miRNA)-based predictive model for prostate cancer patients of 1) time to biochemical recurrence after radical prostatectomy and 2) salvage radiation therapy following documented disease progression post-radical prostatectomy.Forty three who had undergone failure with greater than 4 years follow-up data were identified. Formalin-fixed, paraffin-embedded tissue blocks collected all total RNA was isolated from 1mm cores enriched tumor (>70%). Eight hundred miRNAs analyzed...
2016 Background: This study sought to examine the prognostic value of mutations within IDH1/2, ATRX, CIC, FUBP1, and TERT promoter in a phase III grade astrocytomas using multivariate analyses (MVAs). Methods: IDH were determined by immunohistochemistry and/or next-generation sequencing. A custom Ion AmpliSeq DNA panel was used for mutation analysis; detected Sanger Progression-free survival (PFS) overall (OS) estimated Kaplan-Meier method. Hazard ratios (HRs) calculated tested Cox...
Abstract Post-resection radiologic monitoring to identify areas of new or progressive enhancement concerning for cancer recurrence is critical during patients with glioblastoma follow-up. However, treatment-related pseudoprogression presents similar imaging features but requires different clinical management. While pathologic diagnosis the gold standard differentiate true progression and pseudoprogression, lack objective standards admixed histologic presentation creates needs (1) validate...
Abstract Rapid tumor growth, widespread brain-invasion, and therapeutic resistance critically contribute to glioblastoma (GBM) recurrence dismal patient outcomes. Although GBM stem cells (GSC) are shown play key roles in these processes, the molecular pathways governing GSC phenotype (GBM-stemness) remain poorly defined. Here, we show that epigenetic silencing of miR-146a significantly correlated with worse outcome importantly, level was lower recurrent tumors compared primary ones. Further,...
The purposes of this study were (i) to investigate the differences in effects between 160-kV low-energy and 6-MV high-energy X-rays, both by computational analysis vitro studies; (ii) determine each on platinum-sensitized F98 rat glioma murine B16 melanoma cells; (iii) describe cytotoxicity vivo toxicity a Pt(II) terpyridine platinum (Typ-Pt) complex. Simulations performed using Monte Carlo code Geant4 enhancement absorption low- versus X-rays Pt dose factors (DEFs) for Pt-sensitized tumor...
Epilepsy at presentation is an independent favorable prognostic factor in glioblastoma (GBM). In this study, we analyze the oncologic signaling pathways that associate with epilepsy human GBMs, and can underlie effect. Following ethical approval patient consent, fresh frozen GBM tissue was obtained from 76 surgeries. Hospital records were screened for presence of seizures disease. mRNA miRNA expression-based gene set enrichment analyses performed on these tissues, to uncover candidate...