A5040181649- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Cancer-related cognitive impairment studies
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Management of metastatic bone disease
- CNS Lymphoma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- MRI in cancer diagnosis
- Radiopharmaceutical Chemistry and Applications
- Musculoskeletal pain and rehabilitation
- Neuroscience and Neuropharmacology Research
- Advanced Neuroimaging Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Pain Management and Placebo Effect
- Pituitary Gland Disorders and Treatments
- Cancer Treatment and Pharmacology
- Cancer survivorship and care
University Medical Center Utrecht
2016-2025
Heidelberg University
2016-2024
University Hospital Heidelberg
2016-2024
Utrecht University
2011-2024
SBOH
2022
University Hospital and Clinics
2020-2022
University Medical Center
2022
E Ink (South Korea)
2018
University of Liège
2015-2016
Hersenstichting
2016
Bing Neel syndrome is a rare disease manifestation of Waldenström's macroglobulinemia that results from infiltration the central nervous system by malignant lymphoplasmacytic cells. In this guideline we describe clinical symptoms, as well appropriate laboratory and radiological studies, can aid in diagnosis. The presentation may be very diverse, includes headaches, cognitive deficits, paresis, psychiatric symptoms. present patients with known macroglobulinemia, even absence systemic...
A scorecard to evaluate magnetic resonance imaging (MRI) findings during the course of leptomeningeal metastases (LM) has been proposed by Response Assessment in Neuro-Oncology (RANO) group.To explore feasibility Leptomeningeal (LANO) scorecard, cerebrospinal MRIs 22 patients with LM from solid tumors were scored 10 neuro-oncologists and 9 neuroradiologists at baseline follow-up after treatment. Raters blinded for clinical data including Agreement between raters single items was evaluated...
Epileptogenic glioblastomas are thought to convey a favorable prognosis, either due early diagnosis or potential antitumor effects of antiepileptic drugs. We investigated the relationship between survival and epilepsy at presentation, diagnosis, drug therapy in glioblastoma patients. Multivariable Cox regression was applied data 647 consecutive patients diagnosed with de novo 2005 2013 order investigate association In addition, we quantified valproic acid (VPA) treatment. Epilepsy correlated...
We investigated the long-term functional stability and home use of a fully implanted electrocorticography (ECoG)-based brain-computer interface (BCI) for communication by an individual with late-stage Amyotrophic Lateral Sclerosis (ALS).
Abstract Depressive symptoms are common in glioma patients, and can negatively affect health-related quality of life (HRQOL). We performed a nation-wide randomized controlled trial to evaluate the effects an online guided self-help intervention for depressive adult patients. Glioma patients with were 5-week course based on problem-solving therapy, or waiting list control group. After having received intervention, patient groups combined compared cancer outside central nervous system (non-CNS...
Impairments in neurocognitive functioning (NCF) frequently occur glioma patients. Both the tumor and its treatment contribute to these impairments. We aimed quantify NCF patients before investigate which factors influence NCF.We performed a retrospective cohort study diffuse according STROBE (Strengthening Reporting of Observational Studies Epidemiology) criteria. All had undergone neuropsychological assessment as part routine clinical care, awake surgery. studied "overall NCF" 5 domains...
Abstract Background Validation of the 2016 RANO MRI scorecard for leptomeningeal metastasis failed multiple reasons. Accordingly, this joint EORTC Brain Tumor Group and effort sought to prospectively validate a revised response assessment in metastasis. Methods Coded paired cerebrospinal 20 patients with metastases from solid cancers at baseline follow-up after treatment instructions were provided via imaging platform. The Kappa coefficient was used evaluate interobserver pairwise agreement....
Summary Background Integrin signaling is an attractive target for anti-cancer treatment. GLPG0187 a broad spectrum integrin receptor antagonist (IRA). inhibited tumor growth and metastasis in mouse models. Methods We aimed to determine the Recommended Phase II Dose (RP2D) assess safety tolerability of continuous i.v. infusion patients with advanced malignant solid tumors. Anticipated dose levels were 20, 40, 80, 160, 320, 400 mg/day modified 3 + design. Plasma concentrations assessed...
Abstract Although biopsies and tumor resection are prognostically beneficial for glioblastomas (GBM), potential negative effects have also been suggested. Here, using retrospective study of patients intravital imaging mice, we identify some these aspects, including stimulation proliferation migration non-resected cells, provide a strategy to prevent adverse effects. By repeated high-resolution microscopy, show that biopsy-like injury in GBM induces cells through chemokine (C-C motif) ligand...
Abstract Background Cognitive impairment is a common and debilitating symptom in patients with diffuse glioma, the result of multiple factors. We hypothesized that molecular tumor characteristics influence neurocognitive functioning (NCF), aimed to identify tumor-related markers NCF glioma patients. Methods examined relation between cognitive performance (executive function, memory, psychomotor speed) intratumoral expression levels treatment-naive glioma. performed single-center study...
While patients with diffuse low-grade glioma (LGG) often survive for years, there is a risk of tumor progression which may impact patients' long-term health-related quality life (HRQOL) and neurocognitive functioning (NCF). We present follow-up LGG their informal caregivers (T3) who took part in our previous HRQOL investigations (T1, M = 7 T2 13 years after diagnosis).Participants completed (short form-36 health survey [SF-36]; EORTC-BN20), fatigue (Checklist Individual Strength [CIS]),...
Abstract Objective To report T 1 / 2 -values of normal and appearing brain tissues (NBTs, healthy volunteers; NABTs, patients) acquired with a whole-brain 5-minute Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) protocol, to explore relaxometry behavior tumor multiple sclerosis patient. Methods MR-STAT was 49 participants (39 patients neurological pathologies, age range: 21–79 years) at 3 T. Mean were computed for: grey matter (NGM/NAGM)/white (NWM/NAWM)/thalamus/putamen/caudate...
Primary central nervous system lymphoma (PCNSL) is an aggressive with a generally poor prognosis (Zeremski et al, 2016). Early diagnosis can result in timely start of treatment and might improve prognosis. Histopathological analysis brain biopsy regarded as the gold standard for diagnosis, but this invasive procedure possibility severe complications (Khatab 2014). Alternatively, lumbar puncture cerebrospinal fluid (CSF) less be used diagnostic work-up tumours. When by cytomorphology flow...
Abstract Purpose Deficits in neurocognitive functioning (NCF) frequently occur glioma patients. Both treatment and the tumor itself contribute to these deficits. In order minimize harmful effects of surgery, an increasing number patients undergo awake craniotomy. To investigate whether we can indeed preserve cognitive after state-of-the art surgery identify factors determining postoperative NCF, performed a retrospective cohort study. Methods diffuse (WHO grade 2–4) undergoing craniotomy,...
Introduction The subventricular zone (SVZ) in the brain is associated with gliomagenesis and resistance to treatment glioblastoma. In this study, we investigate prognostic role biological characteristics of involvement Methods We analyzed T1-weighted, gadolinium-enhanced MR images a retrospective cohort 647 primary glioblastoma patients diagnosed between 2005–2013, performed multivariable Cox regression analysis adjust effect SVZ for clinical patient- tumor-related factors. Protein...
Abstract Purpose CXCR4 (over)expression is found in multiple human cancer types, while expression low or absent healthy tissue. In glioblastoma it associated with a poor prognosis and more extensive infiltrative phenotype. can be targeted by the diagnostic PET agent [ 68 Ga]Ga-Pentixafor its therapeutic counterpart 177 Lu]Lu-Pentixather. We aimed to investigate of tissue further examine potential these agents. Methods mRNA was examined using R2 genomics platform. Glioblastoma cores were...
Abstract Background Diffuse gliomas (WHO grade II–IV) are progressive primary brain tumors with great variability in prognosis. Cognitive deficits of important prognostic value for survival diffuse gliomas. Until now, few studies focused on domain-specific neuropsychological assessment and rather used MMSE as a measure cognitive functioning. Additionally, these did not take WHO 2016 diagnosis into account. We performed retrospective cohort study the aim to investigate independent...